[关键词]血管性痴呆;丹参多酚酸B;氧糖剥夺;细胞焦亡;NLRP3/Caspase-1/GSDMD信号通路；网络药理学[中图分类号]R285.5 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.04.008

    [Abstract]Objective To explore thepotential molecular mechanisms of salvianolicacidB (Sal B)in treating vascular dementia(VD)throughnetworkpharmacologyandexperimentalverification.MethodsNetworkpharmacologywasusedto identifythepotentialargetsofalBinterventioninVD.Aprotein-proteininteraction(PP)networkwasonstructed，folloed by GO and KEGG pathwayenrichmentanalyses todetermine biologicallrelevant target pathways.Moleculardocking wasperfored toevaluate theinteractionbetweenSalBanditstargets.TheoptimalconcentrationofSalBwasdeterminedvia CCK-8assay thecellorphologywasobservedunderamicroscope，andthereleaserateoflactatedehydrogenase(LDH)inthecellsupeatant wasmeasuredusingamicroplatereader.The levelsof inflammatoryfactorsweremeasuredbyELISA，theproteinexpresionof NLRP3wasexaminedbyimmunofluorescence ......