本文引用：，.基于“脾肾互赞\"理论探讨内质网应激在多囊卵巢综合征中的作用[J].湖南中医药大学学报，2025，45(5)：939-944.

    [关键词]脾肾互赞；多囊卵巢综合征；内质网应激；未折叠蛋白质应答；补肾健脾法 [中图分类号]R271.1 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.05.023

    [Abstract]Polycysticovarysyndrome (PCOS) is a common reproductive endocrine system disease，and its pathogenesis is not completelyclear.Endoplasmicreticulumstress (ERS)isinvovedintheoccurrenceanddevelopmentofPCOSthroughtheunfolded proteinresponsesignalingpathwayhichisoselyelatedtoteathologicalproceessuchasgraulosacellapoptosiseive androgenchroniciflammation，andisulinsistance(I)ERSexhbitsaualoleinprotetingcelsandpromotingpotosis.It sharesmechanisticsimilaritieswiththetheoryof\"splen-kidneymutualpromotion\"inChinesemedicine，whereinspleenand kidneysynergisticallymaintainhebodyhealthunderphysiologicalconditions，yetleadtomutualdamageandcontributetodisease progressionunderpathologicalstates.Splenandkidneydeficiencycanlead to intracelularenvironmentdisorder，andthusinduce ERS，thecontinuousactivationof which furtheraggravatesthemetabolicandreproductivedysfunctionof COS.Basedonthe theoryof\"spleen-kidneymutualpromotion ......