基于“阳微阴弦\"理论探讨血管平滑肌细胞增殖与迁移在动脉粥样硬化中的作用
本文引用:.基于“阳微阴弦\"理论探讨血管平滑肌细胞增殖与迁移在动脉粥样硬化中的作用[J].湖南中医药大学学报,2025,45(5):933-938.[关键词]动脉粥样硬化;血管平滑肌细胞;细胞增殖;细胞迁移;表型转化;阳微阴弦;胸痹心痛 [中图分类号]R256.2 [文献标志码]A [文章编号]doi:10.3969/j.issn.1674-070X.2025.05.022
[Abstract]Atherosclerosis (AS)isacomplexvasculardisease characterizedbylipiddepositionandtheaccumulatioof inflammatorycellwithinthearterialwall,oftenleadingtoadversecardiovascularandcerebrovascularevents.Inrecentyears, vascularsmoth musclecell(VSMC)phenotypicswitching,particularlytetransitionfromtheontractiletothesyntheticphenotype, hasbeenrecognizedasakeymechanism inASprogresionContractile VSMCsprimarilymaintainvasculartoneandstructural stability,werassthticVshitanedsreoryproiferative,ndgatoyapacitis,trebypromotingpatolical vascularremodeling.InTCMtheorythefunctionalcharacteristicsofcontractileVSMCscanbeanalogizedto\"yang\",whilethe biosyntheticactivityofsytheticVMCscorespondsto\"yin\",Tedynamictransformationbetweethephenotypescoresods,to acertainextent,withtheTCMpathogenetictheoryof\"yangdeficiencyandyinexcess\".Basedonthis,thestudyintegratesthe
TCMtheorywithmoderncelularandmolecularmechanismstoinvestigatetheroleofVSMCphenotypicswitchingintheAS pathogenesis.Aditionaly ......
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