[关键词]I型单纯疱疹病毒;单纯疱疹病毒性角膜炎;钩藤提取物;Bcl-2相关X蛋白;B细胞淋巴瘤因子-2；胱天蛋白酶-3

    [中图分类号]R285.5 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.004

    Effects of Uncaria rhynchophylla extracts on recurrent herpes simplex keratitis in experimental rabbits via the Bax/Bcl-2 signaling pathway

    JIA NG Zhi ^I，2 ，WANG Lei， LIU Xuewu2， ZHANG Xiaodong2， PENG Dongdong2，CHEN Xiangchi2， WANG Xiaoqing2， JIA NG Dejian2， XIA Xinhua'*

    1.Schoolof Pharmacy，Hunan UniversityofChinese Medicine，Changsha，Hunan41O2O8，China;2.HunanKeyLaboratoryof PharmacodynamicsandSafety Evaluationof New Drugsamp; HunanPrima Drug Research CenterCo.，Ltd.，Changsha，Hunan 410331，China; 3.Xiangya Schol ofBasicMedical Sciences，CentralSouth University， Changsha， Hunan41Ool3，China

    [Abstract]ObjectiveToinvestigatetheeffectsofUncariarhynchophyllextractsonrecurentherpessimplexkeratitis (HSK)inexperimentalabbitsbasedontecl-2asoiatedXprotein(BaxBcellympoafactor2(Bcl-2)signalingpathway MethodsFortycommon-gradebig-earedwhiterabitswererandomlydividedintonormalcontrol group，modelcontrol group， acyclovirgroupaqueousextractof Uncariarhchophyllagroup ......