[关键词]脑缺血再灌注损伤；芒柄花素；铁死亡；ACSL4/LPCAT3/GPX4轴；神经保护 [中图分类号]R285.5 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.001

    Formononetin alleviates neuronal ferroptosis in cerebral ischemiareperfusion injury by modulating ACSL4/LPCAT3/GPX4 expression

    MA Qiang'， OUYANG Xinyi'， YAN Siyang2， LIU Lijuan2， ZHOU Desheng2* 1.HunanUniversityofChineseMedicine，ChangshaHunan41O2O8，China;2.TheFirstHospitalofHunanUniersityof Chinese Medicine，Changsha， Hunan 41ooo7，China

    [Abstract]Objective Toinvestigatewhetherformononetinexertsneuroprotectivefectsincerebral ischemia-reperfusion injury(CIRI)byregulatingtheACSL4/LPCAT3/GPX4signalingaxistoinhibitneuronalferoptosis.MethodsThemodifiedsuture methodwasused to establish aratmodel of midlecerebral arteryocclusion/reperfusion (MCAO/R).Ashamoperationgroup ......