[关键词]脑缺血再灌注；中药；中药单体；中药复方；发病机制；作用机制 [中图分类号]R255.2 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.029

    Injury mechanisms at different stages of cerebral ischemia-reperfusion and the interventional effects of Chinese medicines

    ZHOU Xin'，LI Lan'， FU Ziyu’， OUYANG Linqi'，HU Hua’， CHEN Zhen’， DENG Guiming ^I，2： ￥ 1.The First Hospital of Hunan University of Chinese Medicine，Changsha， Hunan 41Ooo7，China; 2.The Second Hospital of Hunan University of Chinese Medicine，Changsha， Hunan 41ooo5，China

    [Abstract]Cerebralischemia-reperfusioninjury(CIRI)，acommoncomplicationfollowingstroke，ischaracterizedbycomplex pathogenesisandpoorclinicalprognosis.CIRIcanbedividedintothreephases：acuteischemiaearlyreperfusion，andlate reperfusionEachphaseexhibitsdistinctyetinterconnectedinjurymechanismsthatcolectivelyacceleratediseaseprogession， ultimatelyleading toirreversiblebraindamage.Theacuteischemicphaseisdominatedbyenergymetabolismdysfunctioand calciumoverload;theearlyreperfusionphaseismarkedbysevereoxidativestressandinflammatoryresponses;whilethelate reperfusionphaseinvolvesferroptosisandimpairedneurogenesis ......