8-溴-7-甲氧基白杨素诱导人肺癌细胞凋亡及其机制的探讨(2)
综上所述,BrMchR具有诱导人肺癌A549细胞凋亡的作用,其分子机制可能是通过逆转P53基因超甲基化而诱导A549细胞凋亡,发挥抗肿瘤效应。这一研究结果为肺癌的新药开发提供了新的思路。
参考文献
[1]安东建,邹敏,曹建国.8-溴-7-甲氧基白杨素对人小细胞肺癌细胞增殖和凋亡的影响[J].临床肿瘤学杂志,2010,15(1):16～20.
[2]Zheng X,Meng WD,Xu YY,et al.Synthesis and anticancer effect of chrysin derivatives[J].Bioorg Med Chem Lett,2003,13(5):881～884.
[3]Sykiotis GP,Papavassiliou AG.Apoptosis:the suicide solution in cancer treatment and chemoprevention[J].Expert Opin Investing Drugs,2006,15(6):575～577.
[4]Esteller M.DNA methylation and cancer therapy: new developments and expectation[J].Curr Opin Oncol,2005,17:55～60.
[5]Feinberg AP,tycko B.The history of cancer epigenetics[J].Nat Rev Cancer,2004,4:143～153.
[6]Miriana Petrovich,Dmitry B.Veprintsev.Effects of CpG methylation on recognition of DNA by the tumour suppressor p53[J].J Mol Biol,2009,386(1～2):72～80.
[7]Karen Woodson,Joel Mason,Sang-Woon Choi,et al. Hypomethylation of p53 in Peripheral Blood DNA Is Associated with the Development of Lung Cancer[J].Cancer Epidemiology,Biomarkers & Prevention,2001,23(10):69～74.
【收稿日期】 2011-01-10, http://www.100md.com(单文娟 安东建 曹建国)
参考文献
[1]安东建,邹敏,曹建国.8-溴-7-甲氧基白杨素对人小细胞肺癌细胞增殖和凋亡的影响[J].临床肿瘤学杂志,2010,15(1):16～20.
[2]Zheng X,Meng WD,Xu YY,et al.Synthesis and anticancer effect of chrysin derivatives[J].Bioorg Med Chem Lett,2003,13(5):881～884.
[3]Sykiotis GP,Papavassiliou AG.Apoptosis:the suicide solution in cancer treatment and chemoprevention[J].Expert Opin Investing Drugs,2006,15(6):575～577.
[4]Esteller M.DNA methylation and cancer therapy: new developments and expectation[J].Curr Opin Oncol,2005,17:55～60.
[5]Feinberg AP,tycko B.The history of cancer epigenetics[J].Nat Rev Cancer,2004,4:143～153.
[6]Miriana Petrovich,Dmitry B.Veprintsev.Effects of CpG methylation on recognition of DNA by the tumour suppressor p53[J].J Mol Biol,2009,386(1～2):72～80.
[7]Karen Woodson,Joel Mason,Sang-Woon Choi,et al. Hypomethylation of p53 in Peripheral Blood DNA Is Associated with the Development of Lung Cancer[J].Cancer Epidemiology,Biomarkers & Prevention,2001,23(10):69～74.
【收稿日期】 2011-01-10, http://www.100md.com(单文娟 安东建 曹建国)