98例腋窝淋巴结转移乳腺癌术后辅助化疗疗效及敏感基因研究(3)
综上,对腋窝淋巴结转移乳腺癌术后辅助化疗化效进行观察,并对敏感基因展开研究,利于治疗方案的制定,对保障患者预后的改善有非常重要的意义,值得临床引起重视。PIK3CA为术后辅助化疗应用AC-D方案的较为敏感基因。
[参考文献]
[1] 贺青卿,庄大勇,郑鲁明,等.乳腺癌内乳淋巴结病理状态的再认识:附229例内乳淋巴结活检报告[J].中华内分泌外科杂志,2011,5(5):335-339.
[2] Ligresti G,Militello L,Steelman LS,et al.PIK3CA mutations in human solid tumors:role in sensitivity to various therapeutic approaches[J].Cell Cycle,2009,8(9):1352-1360.
[3] 张少华,江泽飞.乳腺癌保乳术后规范化治疗[J].中华普外科手术学杂志:电子版,2008,2(2):23-25.
[4] Flaviia R.Mangone,Lrina G.Bobrovnitchaia,Sibeli Salaorni,et al.PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients[J].Clinics(Sao Paulo),2012,67(11):1285-1290.
[5] 李志华,苏逢锡,贾卫娟,等.ER、PR、HER-2/neu与乳腺癌新辅助化疗有效率的关系研究[J].岭南现代临床外科,2007,7(5):339-342.
[6] Boyault S,Drouet Y,Navarro C,et al.Mutational characterization of individual breast tumors:TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes[J].Breast Cancer Res Treat,2012,132(1):29-39.
[7] 陈登峰.CEF方案序贯多西他赛辅助化疗治疗45例淋巴结阳性乳腺癌[J].肿瘤学杂志,2010(3):184-186.
[8] 桑果,王本忠.乳腺癌新辅助化疗不同方案近期疗效观察及化疗前后Ki-67的表达变化[J].安徽医科大学学报,2011,46(11):1181-1185.
(收稿日期:2015-06-06), 百拇医药(沈晓健)
[参考文献]
[1] 贺青卿,庄大勇,郑鲁明,等.乳腺癌内乳淋巴结病理状态的再认识:附229例内乳淋巴结活检报告[J].中华内分泌外科杂志,2011,5(5):335-339.
[2] Ligresti G,Militello L,Steelman LS,et al.PIK3CA mutations in human solid tumors:role in sensitivity to various therapeutic approaches[J].Cell Cycle,2009,8(9):1352-1360.
[3] 张少华,江泽飞.乳腺癌保乳术后规范化治疗[J].中华普外科手术学杂志:电子版,2008,2(2):23-25.
[4] Flaviia R.Mangone,Lrina G.Bobrovnitchaia,Sibeli Salaorni,et al.PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients[J].Clinics(Sao Paulo),2012,67(11):1285-1290.
[5] 李志华,苏逢锡,贾卫娟,等.ER、PR、HER-2/neu与乳腺癌新辅助化疗有效率的关系研究[J].岭南现代临床外科,2007,7(5):339-342.
[6] Boyault S,Drouet Y,Navarro C,et al.Mutational characterization of individual breast tumors:TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes[J].Breast Cancer Res Treat,2012,132(1):29-39.
[7] 陈登峰.CEF方案序贯多西他赛辅助化疗治疗45例淋巴结阳性乳腺癌[J].肿瘤学杂志,2010(3):184-186.
[8] 桑果,王本忠.乳腺癌新辅助化疗不同方案近期疗效观察及化疗前后Ki-67的表达变化[J].安徽医科大学学报,2011,46(11):1181-1185.
(收稿日期:2015-06-06), 百拇医药(沈晓健)