酒精依赖患者功能磁共振脑结构的改变研究(1)
[摘要] 目的 酒精依赖患者功能磁共振脑结构的改变研究。方法 收集该院2012年3月—2015年6月诊治的50例酒精依赖患者，同时收集同期健康体检的人员50例，均采用美国通用G3.0磁共振进行MRI进行检查，同时采用MQ反映被试总的记忆能力，采用韦氏记忆量表和韦氏成人智力量表测试认知功能。结果 两组人员MRI体积检查比较：观察组左侧脑室颞角宽度(4.758±1.048)nm，左侧海马体积(2.205±0.311)m3，右侧侧脑室颞角宽度(4.745±1.026)nm，右侧海马体积(2.242±0.356)m3，对照组左侧脑室颞角宽度(2.286±0.216)nm，左侧海马体积(3.177±0.246)m3，右侧侧脑室颞角宽度(2.279±0.222)nm，右侧海马体积(3.151±0.211)m3，两组比较差异有统计学意义(P<0.05)，两组人员韦氏成人智力量表(WAI)、韦氏记忆商及因子分比较差异有统计学意义(P<0.05)。 结论 酒精依赖患者存在明显的认知功能损害及脑结构异常，限制酒精摄入量或戒酒是预防酒精依赖的关键。
[关键词] 酒精依赖；记忆量表；总记忆商数；成人智力量表；磁共振
[中图分类号] R81 [文献标识码] A [文章编号] 1674-0742(2016)03(b)-0180-03
[Abstract] Objective To research the function magnetic resonance imaging(MRI) in changes of brain structure in patients with alcohol dependence. Methods 50 cases of patients with alcohol dependence diagnosed and treated in our hospital from March 2012 to June 2015 were collected， and 50 cases of healthy physical examined people were collected at the same time， and all of them were given MRI examination by American general G3.0 magnetic resonance， the memory ability was reflected by MQ， and the cognitive function was tested by Wechsler Memory Scale and Wechsler Adult Intelligence Scale. Results The comparison of MRI volume examination of the two groups showed that the left lateral ventricle temporal horn width， left hippocampal volume， right lateral ventricle temporal horn width and right hippocampal volume were respectively(4.758±1.048) nm， (2.205±0.311) m3， (4.745±1.026) nm and (2.242±0.356) m3 in the observation group and (2.286±0.216) nm， (3.177±0.246) m3， (2.279±0.222) nm and (3.151±0.211) m3 in the control group， and there were obvious differences between the two groups by comparison(P<0.05)， the differences in the Wechsler Adult Intelligence Scale(WAI) and Wechsler Memory quotient and factor scores between the two groups were statistically significant(P<0.05). Conclusion The patients with alcohol dependence have obvious cognitive impairments and？structural brain abnormalities， and limiting alcohol intake or temperance is the key to prevent alcohol dependence.
[Key words] Alcohol dependence； Memory scale； MQ； Adult Intelligence Scale； Magnetic Resonance
酒精是一种饮品，我国有着几千年的酒文化，然而，酒精对中枢神经系统有广泛的影响， 会导致酒精依赖及精神疾病的发生[1]。目前，国外对酒精依赖患者的研究逐步增多，特别是磁共振的应用，在探索其脑结构的研究也日趋增多，国内对酒精依赖患者的脑结构研究比较鲜见，为探讨酒精依赖患者磁共振脑结构的变化，更精确的提供诊断依据和治疗措施，该研究收集该院2012年3月—2015年6月诊治的50例酒精依赖患者进行回顾性分析，现报道如下。
1 资料与方法
1.1 一般资料
收集该院2012年3月—2015年6月诊治的50例酒精依赖患者，均为男性，年龄29～66岁，平均年龄(51.2±5.5)岁，职业：农民22例，工人19例，个体2例，干部5例，无业2例。同时收集同期健康体检的人员50例男性进行比较，年龄22～61岁，平均年龄(45.2±1.5)岁，职业：农民14例，工人20例，个体4例，干部9例，无业3例。两组人员在年龄、职业方面比较差异无统计学意义(P>0.05)，有可比性。 (张慧芳 李志刚 梁峰 侯晓芳 宁彩红 郭艳平)
[关键词] 酒精依赖；记忆量表；总记忆商数；成人智力量表；磁共振
[中图分类号] R81 [文献标识码] A [文章编号] 1674-0742(2016)03(b)-0180-03
[Abstract] Objective To research the function magnetic resonance imaging(MRI) in changes of brain structure in patients with alcohol dependence. Methods 50 cases of patients with alcohol dependence diagnosed and treated in our hospital from March 2012 to June 2015 were collected， and 50 cases of healthy physical examined people were collected at the same time， and all of them were given MRI examination by American general G3.0 magnetic resonance， the memory ability was reflected by MQ， and the cognitive function was tested by Wechsler Memory Scale and Wechsler Adult Intelligence Scale. Results The comparison of MRI volume examination of the two groups showed that the left lateral ventricle temporal horn width， left hippocampal volume， right lateral ventricle temporal horn width and right hippocampal volume were respectively(4.758±1.048) nm， (2.205±0.311) m3， (4.745±1.026) nm and (2.242±0.356) m3 in the observation group and (2.286±0.216) nm， (3.177±0.246) m3， (2.279±0.222) nm and (3.151±0.211) m3 in the control group， and there were obvious differences between the two groups by comparison(P<0.05)， the differences in the Wechsler Adult Intelligence Scale(WAI) and Wechsler Memory quotient and factor scores between the two groups were statistically significant(P<0.05). Conclusion The patients with alcohol dependence have obvious cognitive impairments and？structural brain abnormalities， and limiting alcohol intake or temperance is the key to prevent alcohol dependence.
[Key words] Alcohol dependence； Memory scale； MQ； Adult Intelligence Scale； Magnetic Resonance
酒精是一种饮品，我国有着几千年的酒文化，然而，酒精对中枢神经系统有广泛的影响， 会导致酒精依赖及精神疾病的发生[1]。目前，国外对酒精依赖患者的研究逐步增多，特别是磁共振的应用，在探索其脑结构的研究也日趋增多，国内对酒精依赖患者的脑结构研究比较鲜见，为探讨酒精依赖患者磁共振脑结构的变化，更精确的提供诊断依据和治疗措施，该研究收集该院2012年3月—2015年6月诊治的50例酒精依赖患者进行回顾性分析，现报道如下。
1 资料与方法
1.1 一般资料
收集该院2012年3月—2015年6月诊治的50例酒精依赖患者，均为男性，年龄29～66岁，平均年龄(51.2±5.5)岁，职业：农民22例，工人19例，个体2例，干部5例，无业2例。同时收集同期健康体检的人员50例男性进行比较，年龄22～61岁，平均年龄(45.2±1.5)岁，职业：农民14例，工人20例，个体4例，干部9例，无业3例。两组人员在年龄、职业方面比较差异无统计学意义(P>0.05)，有可比性。 (张慧芳 李志刚 梁峰 侯晓芳 宁彩红 郭艳平)