氯吡格雷治疗不稳定型心绞痛的临床研究(1)
[摘要] 目的 探讨氯吡格雷治疗不稳定型心绞痛的临床效果及价值。方法 方便选取该院于2015年4月—2016年4月间收治的90例不稳定型心绞痛患者为研究对象，随机分为对照组和观察组，各45例。给予对照组常规治疗，给予观察组常规治疗基础上的氯吡格雷治疗，对比两种治疗模式的临床效果。结果 观察组的治疗总有效率为95.56%，治疗后的心绞痛次数、纤维蛋白原、血小板指标分别为(2.1±1.2)次、(4.8±1.1)g/L、(161.0±66.0)×109/L，明显优于对照组，差异有统计学意义(P<0.05)。观察组治疗后的TC、TG、LDL-C、HDL-C水平分别为(2.7±0.6)、(0.6±0.1)、(1.7±0.3)、(1.8±0.4)mmol/L，均优于对照组，两组差异有统计学意义(P<0.05)。 结论 对不稳定型心绞痛患者实施常规治疗基础上的氯吡格雷治疗，疗效显著，值得推广和应用。
[关键词] 氯吡格雷；不稳定型心绞痛；阿司匹林；疗效对比
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2017)02(b)-0099-03
[Abstract] Objective To discuss the clinical effect and value of clopidogrel in treatment of unstable angina pectoris. Methods 90 cases of patients with unstable angina pectoris admitted and treated in our hospital from April 2015 to April 2016 were convenient selected as the research objects and randomly divided into two groups with 45 cases in each， the control group adopted the routine treatment， while the observation group adopted the clopidogrel treatment on the basis of the routine treatment， and the clinical effect of the two treatment methods was compared. Results The total treatment effective rate in the observation group was 95.56%， and the angina pectoris frequency， contractinogen and platelet indexes were respectively (2.1±1.2)， (4.8±1.1)g/L，(161.0±66.0)×109/L， which were obviously better than those in the control group， and the differences had statistical significance(P<0.05)， and the TC， TG， LDL-C and HDL-C levels after treatment in the observation group were respectively(2.7±0.6)， (0.6±0.1)， (1.7±0.3)， (1.8±0.4)mmol/L，Convenient， which were better than those in the control group， and the differences between the two groups had statistical significance(P<0.05). Conclusion The curative effect of the clopidogrel treatment on the basis of the routine treatment for patients with unstable angina pectoris is obvious， which is worth promotion and application.
[Key words] Clopidogrel； Unstable angina pectoris； Aspirin； Comparison of curative effect
不穩定型心绞痛是一种常见的急性冠状动脉综合征，主要由冠状动脉狭窄、痉挛导致血流量突然减少所引起的，其临床表现为心绞痛、胸闷、呼吸不畅等，严重时还会引发急性心肌梗死或者心脏猝死[1]，严重威胁了患者的生命安全和健康。因此应当给予患者积极的治疗，以达到改善预后、稳定病症的效果。该文方便选取该院于2015年4月—2016年4月间收治的90例不稳定型心绞痛患者为研究对象，分组对其实施了常规治疗和氯吡格雷治疗，取得了较明显的对比效果，现报道如下。
1 资料与方法
1.1 一般资料
方便选取该院收治的90例不稳定型心绞痛患者为研究对象，随机分为两组。观察组患者45例，男性24例，女性21例，年龄48～78岁，平均年龄(59.4±2.3)岁，发病类型：恶化劳力型心绞痛10例，初发劳力型心绞痛8例，梗死后心绞痛12例，静息心绞痛9例，变异型心绞痛6例，合并高血压14例，高血脂18例，糖尿病13例。对照组患者45例，男性26例，女性19例，年龄46～81岁，平均年龄(60.3±2.8)岁，发病类型：恶化劳力型心绞痛12例，初发劳力型心绞痛8例，梗死后心绞痛11例，静息心绞痛10例，变异型心绞痛4例，合并高血压12例，高血脂17例，糖尿病16例。两组患者在一般资料上差异无统计学意义(P>0.05)。, http://www.100md.com(帕提古力·苏力坦)
[关键词] 氯吡格雷；不稳定型心绞痛；阿司匹林；疗效对比
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2017)02(b)-0099-03
[Abstract] Objective To discuss the clinical effect and value of clopidogrel in treatment of unstable angina pectoris. Methods 90 cases of patients with unstable angina pectoris admitted and treated in our hospital from April 2015 to April 2016 were convenient selected as the research objects and randomly divided into two groups with 45 cases in each， the control group adopted the routine treatment， while the observation group adopted the clopidogrel treatment on the basis of the routine treatment， and the clinical effect of the two treatment methods was compared. Results The total treatment effective rate in the observation group was 95.56%， and the angina pectoris frequency， contractinogen and platelet indexes were respectively (2.1±1.2)， (4.8±1.1)g/L，(161.0±66.0)×109/L， which were obviously better than those in the control group， and the differences had statistical significance(P<0.05)， and the TC， TG， LDL-C and HDL-C levels after treatment in the observation group were respectively(2.7±0.6)， (0.6±0.1)， (1.7±0.3)， (1.8±0.4)mmol/L，Convenient， which were better than those in the control group， and the differences between the two groups had statistical significance(P<0.05). Conclusion The curative effect of the clopidogrel treatment on the basis of the routine treatment for patients with unstable angina pectoris is obvious， which is worth promotion and application.
[Key words] Clopidogrel； Unstable angina pectoris； Aspirin； Comparison of curative effect
不穩定型心绞痛是一种常见的急性冠状动脉综合征，主要由冠状动脉狭窄、痉挛导致血流量突然减少所引起的，其临床表现为心绞痛、胸闷、呼吸不畅等，严重时还会引发急性心肌梗死或者心脏猝死[1]，严重威胁了患者的生命安全和健康。因此应当给予患者积极的治疗，以达到改善预后、稳定病症的效果。该文方便选取该院于2015年4月—2016年4月间收治的90例不稳定型心绞痛患者为研究对象，分组对其实施了常规治疗和氯吡格雷治疗，取得了较明显的对比效果，现报道如下。
1 资料与方法
1.1 一般资料
方便选取该院收治的90例不稳定型心绞痛患者为研究对象，随机分为两组。观察组患者45例，男性24例，女性21例，年龄48～78岁，平均年龄(59.4±2.3)岁，发病类型：恶化劳力型心绞痛10例，初发劳力型心绞痛8例，梗死后心绞痛12例，静息心绞痛9例，变异型心绞痛6例，合并高血压14例，高血脂18例，糖尿病13例。对照组患者45例，男性26例，女性19例，年龄46～81岁，平均年龄(60.3±2.8)岁，发病类型：恶化劳力型心绞痛12例，初发劳力型心绞痛8例，梗死后心绞痛11例，静息心绞痛10例，变异型心绞痛4例，合并高血压12例，高血脂17例，糖尿病16例。两组患者在一般资料上差异无统计学意义(P>0.05)。, http://www.100md.com(帕提古力·苏力坦)