CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣疗效观察(1)
[摘要] 目的 探讨CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣临床疗效。 方法 随机选取2010年7月—2015年1月该院皮肤性病科门诊诊治的191例尖锐湿疣患者，随机分成3组，A组65例，B组63例，C组63例。A组：CO2激光联合咪喹莫特乳膏和重组人干扰素α-2b治疗。B组：CO2激光联合重组人干扰素α-2b治疗。C组：单纯用CO2激光治疗。开始2个月每周随访1次，以后每3周随访1次，随访6个月。结果 A、B、C 3组治愈率分别为93.85%、80.95%、58.73%，复发率分别为6.15%、19.05%、41.27%。使用咪喹莫特乳膏辅助 CO2激光治疗尖锐湿疣的疗效明显优于干扰素α-2b辅助CO2激光与单纯用CO2激光治疗；同时，使用咪喹莫特乳膏辅助CO2激光治疗尖锐湿疣的復发率明显小于其余两种治疗方式，两种差异有统计学意义(P<0.05)。 结论 该研究采用CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣，见效快，治愈率高，复发率低，不良反应少，安全性高，临床值得推广应用。
[关键词] 咪喹莫特；干扰素；尖锐湿疣
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2017)05(b)-0039-03
[Abstract] Objective To observe the clinical curative effect of CO2 laser and Imiquimod cream and interferon in treatment of condyloma acuminate. Methods Random selection 191 cases of patients with condyloma acuminate treated in our hospital from July 2010 to January 2015 were randomly divided into three groups， the group A with 65 cases adopted the CO2 laser and Imiquimod cream and recombinant human interferonα-2b treatment， the group B with 63 cases adopted the CO2 laser and recombinant human interferonα-2b treatment， and the group C with 63 cases only adopted the CO2 laser treatment， in the first two months， all patients were followed up once， and followed up once every three weeks， 6 cases in total. Results The cure rate and recurrence rate in the group A， B and C were respectively 93.85%， 80.95%， 58.73% and 6.15%， 19.05%， 41.27%， and the curative effect of Imiquimod cream and CO2 laser in treatment of condyloma acuminate was obviously better than that of interferon α-2b and CO2 laser and simple CO2 laser， at the same time， the recurrence rate of Imiquimod cream and CO2 laser in treatment of condyloma acuminate was obviously fewer than that of the other treatment methods， and the differences between groups were statistically significant(P<0.05). Conclusion The cure rate of CO2 laser and Imiquimod cream and interferon in treatment of condyloma acuminate is high with rapid effect， low recurrence rate， few adverse reactions and high safety， which is worth promotion and application in clinic.
[Key words] Imiquimod； Interferon； Condyloma acuminate
尖锐湿疣(CA)是一种较为常见的性传播疾病之一，由人类乳头瘤病毒(HPV)感染所致，常发生在肛门及外生殖器等部位，主要通过性接触传播，或是接触性传染所致。尖锐湿疣是全球范围内最常见的STD之一，近年来，尖锐湿疣的发病率有逐年上升的趋势，以性活跃度较高的18～50岁的中青年人患者为最易感染人群，由于该疾病潜伏期(平均3个月)较长，且易反复发作，给患者身心都造成了较大的负面影响。目前为止，临床上治疗尖锐湿疣的方法很多，多采用物理治疗法、化学治疗法、免疫治疗法以及中草药治疗法等方法，通过研究发现采用单一治疗方法疗效不佳，因此，临床上多采用联合治疗法。该文随机选取了该院2010年7月—2015年1月期间采用CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣的病患191例，通过治疗后临床上取得了较为满意的疗效，现报道如下。, 百拇医药(潘选长 林仲法 兰倩华)
[关键词] 咪喹莫特；干扰素；尖锐湿疣
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2017)05(b)-0039-03
[Abstract] Objective To observe the clinical curative effect of CO2 laser and Imiquimod cream and interferon in treatment of condyloma acuminate. Methods Random selection 191 cases of patients with condyloma acuminate treated in our hospital from July 2010 to January 2015 were randomly divided into three groups， the group A with 65 cases adopted the CO2 laser and Imiquimod cream and recombinant human interferonα-2b treatment， the group B with 63 cases adopted the CO2 laser and recombinant human interferonα-2b treatment， and the group C with 63 cases only adopted the CO2 laser treatment， in the first two months， all patients were followed up once， and followed up once every three weeks， 6 cases in total. Results The cure rate and recurrence rate in the group A， B and C were respectively 93.85%， 80.95%， 58.73% and 6.15%， 19.05%， 41.27%， and the curative effect of Imiquimod cream and CO2 laser in treatment of condyloma acuminate was obviously better than that of interferon α-2b and CO2 laser and simple CO2 laser， at the same time， the recurrence rate of Imiquimod cream and CO2 laser in treatment of condyloma acuminate was obviously fewer than that of the other treatment methods， and the differences between groups were statistically significant(P<0.05). Conclusion The cure rate of CO2 laser and Imiquimod cream and interferon in treatment of condyloma acuminate is high with rapid effect， low recurrence rate， few adverse reactions and high safety， which is worth promotion and application in clinic.
[Key words] Imiquimod； Interferon； Condyloma acuminate
尖锐湿疣(CA)是一种较为常见的性传播疾病之一，由人类乳头瘤病毒(HPV)感染所致，常发生在肛门及外生殖器等部位，主要通过性接触传播，或是接触性传染所致。尖锐湿疣是全球范围内最常见的STD之一，近年来，尖锐湿疣的发病率有逐年上升的趋势，以性活跃度较高的18～50岁的中青年人患者为最易感染人群，由于该疾病潜伏期(平均3个月)较长，且易反复发作，给患者身心都造成了较大的负面影响。目前为止，临床上治疗尖锐湿疣的方法很多，多采用物理治疗法、化学治疗法、免疫治疗法以及中草药治疗法等方法，通过研究发现采用单一治疗方法疗效不佳，因此，临床上多采用联合治疗法。该文随机选取了该院2010年7月—2015年1月期间采用CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣的病患191例，通过治疗后临床上取得了较为满意的疗效，现报道如下。, 百拇医药(潘选长 林仲法 兰倩华)