妊娠期亚临床甲减对妊娠结局和胎儿的影响(1)
[摘要] 目的 研究妊娠期亚临床甲减对妊娠结局和胎儿的影响。方法 以该院在2014年12月—2016 年12月期间收治的妊娠期亚临床甲减患者为例，按照纳入标准和排除标准方便选择其中的300例患者作为该次研究对象，按照患者的治疗意愿将其分为两组，每组150例。对照组患者不使用药物治疗，观察组患者针对亚临床甲减进行药物治疗。比较两组患者的妊娠结局和对胎儿产生的影响。结果 两组患者的新生儿不良反应发生率(观察组：4.6%，对照组：26.0%)和孕妇并发症发生率(观察组：7.0%，对照组：34.7%)均存在明显差异，接受药物治疗的观察组患者两项指标均明显低于不接受药物治疗的对照组患者。差异有统计学意义(P<0.05)。 结论 对妊娠期亚临床甲减患者采用药物治疗可以减少产妇不良妊娠结局的发生和婴儿不良反应发生率，使母婴安全得到更好的保障。
[关键词] 妊娠期亚临床甲减；妊娠结局；胎儿；影响
[中图分类号] R714 [文献标识码] A [文章编号] 1674-0742(2017)06(b)-0137-03
[Abstract] Objective To research the effect of subclinical hypothyroidism during the pregnancy period on the pregnant outcome and fetuses. Methods 300 cases of patients with subclinical hypothyroidism during the pregnancy period in our hospital from December 2014 to December 2016 were convenient selected and divided into two groups with 150 cases in each according to the treatment willingness， the control group did not use the drug treatment， while the observation group were treated with subclinical hypothyroidism， and the effect on the pregnant outcome and fetuses was compared between the two groups. Results The differences in the incidence rate of adverse reactions of newborns and incidence rate of complications of pregnant women between the observation group and the control group were obvious， (4.6%， 26.0% vs 7.0%， 34.7%)， and the two indexes in the observation group were obviously lower than those in the control group， and the differences were obvious with statistical significance(P<0.05). Conclusion The drug treatment of patients with subclinical hypothyroidism during the pregnancy period can reduce the occurrence of adverse pregnant outcome of delivery women and incidence rate of adverse reactions of infants thus better ensuring the maternal and infant safety.
[Key words] Subclinical hypothyroidism during the pregnancy period； Pregnant outcome； Fetus； Effect
育齡妇女比较常见的疾病为妊娠合并甲状腺功能减退，此种疾病的发生和患者自身甲状腺免疫存在密切关系[1]。妊娠期亚临床甲减的发生率为3%左右，和多种妊娠不良结局存在不同程度的相关关系[2]。甲状腺功能减退最主要的临床表现是患者甲状腺激素分泌和合成量都呈现下降趋势[3]。也可能是受到某种生理效应，导致最终的机体代谢水平不断下降，进而对产妇的妊娠结局和胎儿的正常发育产生不良影响。该次以该院2014年12月—2016年12月的300例妊娠期亚临床甲减患者为例，分析此种疾病对产妇和胎儿产生的影响，现报道如下。
1 资料与方法
1.1 一般资料
该次研究中随机选取的患者是该院收治的，共计300例。所有患者均被明确诊断为妊娠期亚临床甲减患者，患者的甲状腺过氧化物酶抗体呈现阳性，FT4值降低，甲状腺激素升高等，患者有其中任何一种症状都可以被确诊。排除标准：患有严重器质性疾病和精神障碍疾病患者；对甲状腺药物过敏患者；存在恶性肿瘤患者。所有患者分为观察组和对照组，每组150例患者，观察组患者年龄两组患者的年龄分布在21～36(26.1±7.1)岁；孕龄为7～11(7.5±3.1)周；体重介于45～68(59.4±6.7)kg。对照组患者的年龄分布在22～37(26.6±7.4)岁；孕龄为7～12(7.7±3.3)周；体重介于46～69(59.8±6.9)kg。一般资料差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(陈庆华 何军儒 殷春 盛永齐)
[关键词] 妊娠期亚临床甲减；妊娠结局；胎儿；影响
[中图分类号] R714 [文献标识码] A [文章编号] 1674-0742(2017)06(b)-0137-03
[Abstract] Objective To research the effect of subclinical hypothyroidism during the pregnancy period on the pregnant outcome and fetuses. Methods 300 cases of patients with subclinical hypothyroidism during the pregnancy period in our hospital from December 2014 to December 2016 were convenient selected and divided into two groups with 150 cases in each according to the treatment willingness， the control group did not use the drug treatment， while the observation group were treated with subclinical hypothyroidism， and the effect on the pregnant outcome and fetuses was compared between the two groups. Results The differences in the incidence rate of adverse reactions of newborns and incidence rate of complications of pregnant women between the observation group and the control group were obvious， (4.6%， 26.0% vs 7.0%， 34.7%)， and the two indexes in the observation group were obviously lower than those in the control group， and the differences were obvious with statistical significance(P<0.05). Conclusion The drug treatment of patients with subclinical hypothyroidism during the pregnancy period can reduce the occurrence of adverse pregnant outcome of delivery women and incidence rate of adverse reactions of infants thus better ensuring the maternal and infant safety.
[Key words] Subclinical hypothyroidism during the pregnancy period； Pregnant outcome； Fetus； Effect
育齡妇女比较常见的疾病为妊娠合并甲状腺功能减退，此种疾病的发生和患者自身甲状腺免疫存在密切关系[1]。妊娠期亚临床甲减的发生率为3%左右，和多种妊娠不良结局存在不同程度的相关关系[2]。甲状腺功能减退最主要的临床表现是患者甲状腺激素分泌和合成量都呈现下降趋势[3]。也可能是受到某种生理效应，导致最终的机体代谢水平不断下降，进而对产妇的妊娠结局和胎儿的正常发育产生不良影响。该次以该院2014年12月—2016年12月的300例妊娠期亚临床甲减患者为例，分析此种疾病对产妇和胎儿产生的影响，现报道如下。
1 资料与方法
1.1 一般资料
该次研究中随机选取的患者是该院收治的，共计300例。所有患者均被明确诊断为妊娠期亚临床甲减患者，患者的甲状腺过氧化物酶抗体呈现阳性，FT4值降低，甲状腺激素升高等，患者有其中任何一种症状都可以被确诊。排除标准：患有严重器质性疾病和精神障碍疾病患者；对甲状腺药物过敏患者；存在恶性肿瘤患者。所有患者分为观察组和对照组，每组150例患者，观察组患者年龄两组患者的年龄分布在21～36(26.1±7.1)岁；孕龄为7～11(7.5±3.1)周；体重介于45～68(59.4±6.7)kg。对照组患者的年龄分布在22～37(26.6±7.4)岁；孕龄为7～12(7.7±3.3)周；体重介于46～69(59.8±6.9)kg。一般资料差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(陈庆华 何军儒 殷春 盛永齐)