非酒精性脂肪肝病与CK18—M65、脂联素水平的相关性研究(1)
[摘要] 目的 探讨非酒精性脂肪肝病(NAFLD)患者血清中CK18-M65、脂联素水平的相关性。 方法 NAFLD组方便选取2013年2月—2014年6月在宁夏医科大学总院体检诊断为NAFLD的患者98例，另选取同期在该院进行体检的健康人群103名作为对照组，对受试者各项指标进行检测分析。 结果 NAFLD组与对照组相比，体质量指数、血压、腰臀比、血糖、血脂、胰岛素、血尿酸、CK18-M65及脂联素差异有统计学意义(26.91±2.15)kg/m2 vs (23.14±1.92)kg/m2，(125.31±6.84)mmHg vs (114.86±7.10)mmHg，(80.49±3.92)mmHg vs (75.28±4.18)mmHg，(0.92±0.18) vs (0.86±0.21)，(5.89±0.61)mmol/L vs (5.44±0.53)mmol/L，(2.26±0.18)mmol/L vs (1.49±0.12)mmol/L，(5.35±0.24)mmol/L vs (5.08±0.31)mmol/L，(1.12±0.08)mmol/L vs (1.31±0.11)mmol/L，(3.12±0.14)mmol/L vs (2.79±0.21)mmol/L，(12.78±0.09)U/mL vs (3.45±0.10)U/mL，(361.54±3.15)μmol/L vs (312.51±2.91)μmol/L，(159.18±3.94)ng/L vs (108.54±4.08)ng/L，(1.60±0.08)μg/mL vs (2.23±0.09)μg/mL (P<0.05)。隨着疾病严重程度的增加，血清CK18-M65及脂联素的表达均显著改变(单纯性脂肪肝组，NASH组，肝纤维化组3组CK18-M65水平分别为(128.14±11.26)，(145.62±9.62)，(167.15±12.08)ng/L；脂联素水平分别为(1.82±0.28)，(1.67±0.19)，(1.52±0.34)μg/mL)]，CK18-M65与脂联素水平呈显著负相关(r=-0.223，P<0.05)。结论 CK18-M65及脂联素在NAFLD患者中表达异常，且NAFLD患者CK18-M65与脂联素表达呈负相关。
[关键词] NAFLD；CK18-M65；脂联素
[中图分类号] R575 [文献标识码] A [文章编号] 1674-0742(2017)08(a)-0034-03
[Abstracts] Objective This paper tries to explore the correlation of non-alcoholic fatty liver disease， CK18-M65 and adiponectin level. Methods Convenient selection 98 cases of non-alcoholic fatty liver disease in this hospital from February 2013 to June. 2014 were selected and divided into NAFLD group. 103 healthy voluntaries in this hospital were selected as control group. The biochemical indexes of the two groups were compared. Results There were significant differences between NASH group and the control group of BMI， blood pressure， WHR， blood glucose， blood fat， insulin， blood uric acid， CK18-M65 and adiponectin of[(26.91±2.15)kg/m2 vs (23.14±1.92)kg/m2， (125.31±6.84)mmHg vs (114.86±7.10)mmHg， (80.49±3.92)mmHg vs (75.28±4.18)mmHg， (0.92±0.18) vs (0.86±0.21)， (5.89±0.61)mmol/L vs (5.44±0.53)mmol/L， (2.26±0.18)mmol/L vs. (1.49±0.12)mmol/L， (5.35±0.24)mmol/L vs. (5.08±0.31)mmol/L， (1.12±0.08)mmol/L vs. (1.31±0.11)mmol/L， (3.12±0.14)mmol/L vs. (2.79±0.21)mmol/L， (12.78±0.09)U/mL vs (3.45±0.10)U/mL， (361.54±3.15)μmol/L vs (312.51±2.91)μmol/L， (159.18±3.94)ng/L vs. (108.54±4.08)ng/L， (1.60±0.08)μg/L vs (2.23±0.09)μg/L](P<0.05). The levels of CK18-M65 in the patients with simple fatty liver group， NASH group and hepatic fibrosis group were (128.14±11.26)， (145.62±9.62) and (167.15±12.08)ng/L respectively. The levels of adiponectin of the three groups were (1.82±0.28)， (1.67±0.19) and (1.52±0.34)μg/mL， and the level of CK18-M65 was significantly negatively correlated with adiponectin (r=-0.223， P<0.05). Conclusion CK18-M65 and adiponectin level was abnormal and CK18-M65 had significantly negative correlation with adiponectin level in patients with non-alcoholic fatty liver disease., 百拇医药(何芳 王芳 王鵷臻 杨少奇)
[关键词] NAFLD；CK18-M65；脂联素
[中图分类号] R575 [文献标识码] A [文章编号] 1674-0742(2017)08(a)-0034-03
[Abstracts] Objective This paper tries to explore the correlation of non-alcoholic fatty liver disease， CK18-M65 and adiponectin level. Methods Convenient selection 98 cases of non-alcoholic fatty liver disease in this hospital from February 2013 to June. 2014 were selected and divided into NAFLD group. 103 healthy voluntaries in this hospital were selected as control group. The biochemical indexes of the two groups were compared. Results There were significant differences between NASH group and the control group of BMI， blood pressure， WHR， blood glucose， blood fat， insulin， blood uric acid， CK18-M65 and adiponectin of[(26.91±2.15)kg/m2 vs (23.14±1.92)kg/m2， (125.31±6.84)mmHg vs (114.86±7.10)mmHg， (80.49±3.92)mmHg vs (75.28±4.18)mmHg， (0.92±0.18) vs (0.86±0.21)， (5.89±0.61)mmol/L vs (5.44±0.53)mmol/L， (2.26±0.18)mmol/L vs. (1.49±0.12)mmol/L， (5.35±0.24)mmol/L vs. (5.08±0.31)mmol/L， (1.12±0.08)mmol/L vs. (1.31±0.11)mmol/L， (3.12±0.14)mmol/L vs. (2.79±0.21)mmol/L， (12.78±0.09)U/mL vs (3.45±0.10)U/mL， (361.54±3.15)μmol/L vs (312.51±2.91)μmol/L， (159.18±3.94)ng/L vs. (108.54±4.08)ng/L， (1.60±0.08)μg/L vs (2.23±0.09)μg/L](P<0.05). The levels of CK18-M65 in the patients with simple fatty liver group， NASH group and hepatic fibrosis group were (128.14±11.26)， (145.62±9.62) and (167.15±12.08)ng/L respectively. The levels of adiponectin of the three groups were (1.82±0.28)， (1.67±0.19) and (1.52±0.34)μg/mL， and the level of CK18-M65 was significantly negatively correlated with adiponectin (r=-0.223， P<0.05). Conclusion CK18-M65 and adiponectin level was abnormal and CK18-M65 had significantly negative correlation with adiponectin level in patients with non-alcoholic fatty liver disease., 百拇医药(何芳 王芳 王鵷臻 杨少奇)