COPD患者的维生素D水平及其与炎症因子的相关性研究(1)
[摘要] 目的 探讨COPD患者的维生素D水平及其與炎症因子的相关性研究。 方法 方便选取2012年5月—2014年5月于该院就诊的COPD患者106例为研究对象，据病情分为慢性阻塞性肺疾病急性发作期为A组53例、B组慢性阻塞性肺疾病稳定期53例，C组53名健康人，行CAT测试，通过ELISA检测3组的25-(OH)D、INF-r、IL-17水平，比较3组之间的相关性。 结果 A组维生素D总缺乏率83.01%高于B组缺乏率81.13%和C组缺乏率5.66%，差异有统计学意义(P<0.05)；3组血清25-(OH)D水平C组(78.89±53.12)ng/mL高于A组(18.86±15.06)ng/mL、B组(37.76±17.96)ng/mL，3组INF-r、IL-17水平A组(57.11±11.02)、(289.88±94.76)pg/mL大于B组(36.69±5.47)、(103.15±43.28)pg/mL，C组(26.23±2.14)、(52.03±5.36)pg/mL，比较结果差异有统计学意义(P<0.05)。 结论 COPD患者的维生素D水平及其与炎症因子有相关性，预防改善患者生活质量。
[关键词] COPD；维生素D水平；炎症因子；相关性
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2017)12(a)-0027-03
[Abstract] Objective To study the vitamin D level of COPD patients and correlation with inflammatory factors. Methods 106 cases of COPD patients diagnosed in our hospital from May 2012 to May 2014 were convenient selected and divided into three groups with 53 cases in each， the group A were patients with chronic obstructive pulmonary diseases acute attack phase， the group B were patients with chronic obstructive pulmonary diseases in the steady phrase， and the group C were health people， underwent the CAT test， and the 25-(OH) D，INF-r， IL-17 levels of the three groups were tested by the ELISA. Results The total deficiency rate of vitamin D in the group a was higher than that in the group B and in the group C，(83.01% vs 81.13%，5.66%)， and the difference was statistically significant(P<0.05)， and the serum 25-(OH)D level in the group C was higher than that in the group A and in the group B[(78.89±53.12)ng/mL vs (18.86±15.06)ng/mL vs (37.76±17.96)ng/mL]， and the INF-r and IL-17 levles in the group A were higher than those in the group B and in the group C[(57.11±11.02)， (289.88±94.76)pg/mL vs (36.69±5.47)，(103.15±43.28)pg/mL vs (26.23±2.14)，(52.03±5.36)pg/mL]， and the differences were statistically significant(P<0.05). Conclusion The vitamin D level of COPD patients is correlated with the inflammatory factor， and we should prevent and improve the quality of life of patients.
[Key words] COPD； Vitamin D level； Inflammatory factor； Correlation
据流行病学调查统计称：我国40岁以上人群中患COPD比率8.5%，COPD在我国死亡原因中占第3位，而在农村占第1位，我国是农业大国，农村人口占据全国人口的82%，因此COPD在我国的预防及治疗具有重大意义，COPD在全世界的发病率也较高[1-2]。COPD是一种可以预防和治疗但无法痊愈的呼吸系统常见疾病，所以提倡“早发现、早诊断、早治疗”。目前越来越多的研究表明：维生素D是预测和调控慢性疾病发病风险的有关因子[3-4]。该文分析2012年5月—2014年5月在该院就诊的COPD患者106例的维生素D水平及其与炎症因子的相关性，现报道如下。
1 资料与方法
1.1 一般资料
方便选取在该院就诊的COPD患者106例为研究对象，A组53例，男29例，女24例，年龄48～75(58.57±9.16)岁；B组53例，男28例，女25例，年龄45～72(56.78±9.57)岁；C组53例，男30例，女23例，年龄43～68(54.66±8.43)岁；3组患者年龄、性别等比较差异无统计学意义(P>0.05)。纳入标准：A、B组患者需符合COPD全球策略修订版中对COPD的诊断标准[5]；所有人及家属均同意参与该研究并签署知情同意书。排除标准：自愿退出研究者。, 百拇医药(韩海燕)
[关键词] COPD；维生素D水平；炎症因子；相关性
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2017)12(a)-0027-03
[Abstract] Objective To study the vitamin D level of COPD patients and correlation with inflammatory factors. Methods 106 cases of COPD patients diagnosed in our hospital from May 2012 to May 2014 were convenient selected and divided into three groups with 53 cases in each， the group A were patients with chronic obstructive pulmonary diseases acute attack phase， the group B were patients with chronic obstructive pulmonary diseases in the steady phrase， and the group C were health people， underwent the CAT test， and the 25-(OH) D，INF-r， IL-17 levels of the three groups were tested by the ELISA. Results The total deficiency rate of vitamin D in the group a was higher than that in the group B and in the group C，(83.01% vs 81.13%，5.66%)， and the difference was statistically significant(P<0.05)， and the serum 25-(OH)D level in the group C was higher than that in the group A and in the group B[(78.89±53.12)ng/mL vs (18.86±15.06)ng/mL vs (37.76±17.96)ng/mL]， and the INF-r and IL-17 levles in the group A were higher than those in the group B and in the group C[(57.11±11.02)， (289.88±94.76)pg/mL vs (36.69±5.47)，(103.15±43.28)pg/mL vs (26.23±2.14)，(52.03±5.36)pg/mL]， and the differences were statistically significant(P<0.05). Conclusion The vitamin D level of COPD patients is correlated with the inflammatory factor， and we should prevent and improve the quality of life of patients.
[Key words] COPD； Vitamin D level； Inflammatory factor； Correlation
据流行病学调查统计称：我国40岁以上人群中患COPD比率8.5%，COPD在我国死亡原因中占第3位，而在农村占第1位，我国是农业大国，农村人口占据全国人口的82%，因此COPD在我国的预防及治疗具有重大意义，COPD在全世界的发病率也较高[1-2]。COPD是一种可以预防和治疗但无法痊愈的呼吸系统常见疾病，所以提倡“早发现、早诊断、早治疗”。目前越来越多的研究表明：维生素D是预测和调控慢性疾病发病风险的有关因子[3-4]。该文分析2012年5月—2014年5月在该院就诊的COPD患者106例的维生素D水平及其与炎症因子的相关性，现报道如下。
1 资料与方法
1.1 一般资料
方便选取在该院就诊的COPD患者106例为研究对象，A组53例，男29例，女24例，年龄48～75(58.57±9.16)岁；B组53例，男28例，女25例，年龄45～72(56.78±9.57)岁；C组53例，男30例，女23例，年龄43～68(54.66±8.43)岁；3组患者年龄、性别等比较差异无统计学意义(P>0.05)。纳入标准：A、B组患者需符合COPD全球策略修订版中对COPD的诊断标准[5]；所有人及家属均同意参与该研究并签署知情同意书。排除标准：自愿退出研究者。, 百拇医药(韩海燕)