二甲双胍缓释片联合门冬胰岛素治疗妊娠期糖尿病对患者血糖及妊娠结局的影响(1)
[摘要] 目的 探讨盐酸二甲双胍缓释片联合门冬胰岛素治疗妊娠期糖尿病(GDM)对患者血糖及妊娠结局的影响。方法 方便选取2015年3月—2017年2月该院妇产科收治的94例GDM患者为研究对象，随机分为观察组(47例，给予盐酸二甲双胍缓释片联合门冬胰岛素治疗)和对照组(47例，给予门冬胰岛素单独治疗)，两组疗程均为4周，观察治疗前后受试者血糖水平变化情况及妊娠结局。结果 治疗1个疗程后，两组受试者各项血糖指标均降低(观察组：tFPG=15.91，t1 hPG=14.23，t2 hPG=23.38，tHbA1c=11.66；对照组：tFPG=13.46，t1 hPG=10.77，t2 hPG=17.23，tHbA1c=7.15)，且观察组各项血糖指标水平显著低于对照组(tFPG=12.63，t1 hPG=10.77，t2 hPG=12.46，tHbA1c=8.91)，差异有统计学意义(P<0.05)；观察组受试者引产、剖宫产、早产发生率分别为4.26%、14.89%、2.13%，均明显低于对照组，差异有统计学意义(P<0.05)。结论 盐酸二甲双胍缓释片与门冬胰岛素皮下注射联合给药方案，能够有效控制GDM患者血糖水平，并有效改善妊娠结局，值得妇产科医师参考。
[关键词] 二甲双胍；门冬胰岛素；妊娠期糖尿病
[中图分类号] R714 [文献标识码] A [文章编号] 1674-0742(2018)01(a)-0134-03
Effects of Metformin Sustained-release Tablets and Insulin Aspart in the Treatment of Gestational Diabetes Mellitus on Blood Glucose and Pregnancy Outcomes
LI Hao
Department of Obstetrics and Gynecology， Hanchuan People’s Hospital， Hanchuan， Hubei Province， 431600 China
[Abstract] Objective This paper tries to observe the effect of metformin combined with aspartic insulin on gestational diabetes mellitus (GDM) in patients with blood glucose and pregnancy outcome. Methods 94 pregnant women which conveniently selected from March 2015 to February 2017，with GDM were divided into observation group (47 cases， given metformin combined with aspartic insulin) and control group (47 cases， given aspartic insulin)， of 4 weeks treatment course， the change of blood glucose level and the outcome of pregnancy before and after treatment of two groups were observed. Results After treatment for one course， the blood glucose levels were reduced in both groups (observation group： tFPG=15.91， t1 hPG=14.23， t2 hPG=23.38， tHbA1c=11.66； control group： tFPG=13.46， t1 hPG=10.77， t2 hPG=17.23， tHbA1c=7.15)； the levels of blood glucose in observation group were significantly lower than control group (tFPG=12.63， t1 hPG=10.77， t2 hPG=12.46， tHbA1c=8.91)， the difference were statistically significant (P<0.05). The induction of labor， the incidence of induction， cesarean section and premature delivery in the observation group were 4.26%， 14.89% and 2.13% respectively， which were significantly lower than those in the control group(P<0.05). Conclusion Metformin combined with aspartic insulin injection can effectively control the blood glucose levels of GDM patients， and effectively improve the outcome of pregnancy.
[Key words] Metformin； Aspartic insulin； Gestational diabetes mellitus
妊娠期糖尿病(GDM)是指在妊娠期間发生或初次诊断的糖代谢异常类疾病[1]。随着人们生活水平的提高及诊疗技术的发展，GDM的发生及检出率逐渐增高[2]。GDM易引发剖宫产、引产等不利结局的发生，对母婴的健康造成消极的影响。控制血糖于正常范围是GDM患者治疗的关键，该研究采用盐酸二甲双胍缓释片联合门冬胰岛素对2015年3月—2017年2月该院94例GDM患者进行治疗，观察患者血糖水平变化情况及妊娠结局，现报道如下。, 百拇医药(李浩)
[关键词] 二甲双胍；门冬胰岛素；妊娠期糖尿病
[中图分类号] R714 [文献标识码] A [文章编号] 1674-0742(2018)01(a)-0134-03
Effects of Metformin Sustained-release Tablets and Insulin Aspart in the Treatment of Gestational Diabetes Mellitus on Blood Glucose and Pregnancy Outcomes
LI Hao
Department of Obstetrics and Gynecology， Hanchuan People’s Hospital， Hanchuan， Hubei Province， 431600 China
[Abstract] Objective This paper tries to observe the effect of metformin combined with aspartic insulin on gestational diabetes mellitus (GDM) in patients with blood glucose and pregnancy outcome. Methods 94 pregnant women which conveniently selected from March 2015 to February 2017，with GDM were divided into observation group (47 cases， given metformin combined with aspartic insulin) and control group (47 cases， given aspartic insulin)， of 4 weeks treatment course， the change of blood glucose level and the outcome of pregnancy before and after treatment of two groups were observed. Results After treatment for one course， the blood glucose levels were reduced in both groups (observation group： tFPG=15.91， t1 hPG=14.23， t2 hPG=23.38， tHbA1c=11.66； control group： tFPG=13.46， t1 hPG=10.77， t2 hPG=17.23， tHbA1c=7.15)； the levels of blood glucose in observation group were significantly lower than control group (tFPG=12.63， t1 hPG=10.77， t2 hPG=12.46， tHbA1c=8.91)， the difference were statistically significant (P<0.05). The induction of labor， the incidence of induction， cesarean section and premature delivery in the observation group were 4.26%， 14.89% and 2.13% respectively， which were significantly lower than those in the control group(P<0.05). Conclusion Metformin combined with aspartic insulin injection can effectively control the blood glucose levels of GDM patients， and effectively improve the outcome of pregnancy.
[Key words] Metformin； Aspartic insulin； Gestational diabetes mellitus
妊娠期糖尿病(GDM)是指在妊娠期間发生或初次诊断的糖代谢异常类疾病[1]。随着人们生活水平的提高及诊疗技术的发展，GDM的发生及检出率逐渐增高[2]。GDM易引发剖宫产、引产等不利结局的发生，对母婴的健康造成消极的影响。控制血糖于正常范围是GDM患者治疗的关键，该研究采用盐酸二甲双胍缓释片联合门冬胰岛素对2015年3月—2017年2月该院94例GDM患者进行治疗，观察患者血糖水平变化情况及妊娠结局，现报道如下。, 百拇医药(李浩)