[摘要] 目的 观察不同麻醉和镇痛方式对宫颈癌根治术患者围术期免疫功能的影响。方法 方便选取2015年9月—2017年9月期间该院接收的50例宫颈癌根治术患者为研究对象，根据麻醉和镇痛方式分为观察组和对照组，各25例，观察组为全麻联合硬膜外麻醉辅以硬膜外镇痛，对照组为靶控芬太尼全麻辅以静脉镇痛，观察两组患者VAS疼痛评分和治疗后免疫功能相关指标的差异。结果 观察组术后24 hVAS评分为(3.32±0.51)分，对照组为(3.48±0.58)分，两组评分差异无统计学意义(P>0.05)，免疫功能方面，观察组的CD3+，CD4+，CD4+/CD8+以及NK细胞水平明显下降，差异有统计学意义(P<0.05)。结论 全麻联合硬膜外麻醉辅以硬膜外镇痛能够有效改善宫颈癌患者细胞免疫功能，从而加快患者的康复。

    [关键词] 麻醉；镇痛；宫颈癌根治术；围手术期；免疫功能

    [中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2018)01(c)-0058-03

    [Abstract] Objective This paper tries to observe the effects of different anesthesia and analgesia on perioperative immune function in patients undergoing cervical cancer. Methods Convenient selection 50 patients with cervical cancer radical surgery received from September 2015 to September 2017 were divided into observation group and control group according to anesthesia and analgesia. The observation group was treated with general anesthesia epidural anesthesia combined with epidural analgesia ......