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甲巯咪唑联合左甲状腺素片对甲状腺功能亢进症患者甲状腺体积及血清 FT3、FT4、TSH 水平的影响(1)
http://www.100md.com 2018年5月5日 《中外医疗》 201813
     [摘要] 目的 了解甲巯咪唑联合左甲状腺素片对甲状腺功能亢进症患者甲状腺体积及机体血清FT3、FT4、TSH水平的影响。方法 以随机法将方便选取该院2014年1月—2016年12月收治的68例甲状腺功能亢进症分成2组:给予甲巯咪唑的34例为对照组,予以甲巯咪唑+左甲状腺素片治疗的34例为治疗组,同时观察、对比2组治疗效果。 结果 治疗组甲状腺体积(12.35±4.60)mL,比对照组(15.62±3.61)mL更低,(t=-3.261;P<0.05);血清FT3(4.42±1.52)pg/mL(t=5.308;P<0.05))、FT4(13.49±1.16)mmol/L水平(t=7.071;P<0.05),比对照组(3.11±0.69)pg/mL、(11.20±1.49)mmol/L高(P<0.05);而TSH水平(2.65±1.21)mIU/L,低于对照组(4.21±1.24)mIU/L,(t=-5.250;P<0.05)。结论 临床治疗甲状腺功能亢进症,联用甲巯咪唑与左甲状腺素片展开治疗,可确保甲状腺体积缩小的同时,较好的改善机体血清FT3、FT4、TSH水平,具有较高的临床推广价值。

    [关键词] 甲巯咪唑;左甲状腺素片;甲状腺功能亢进症

    [中图分类号] R581 [文献标识码] A [文章编号] 1674-0742(2018)05(a)-0106-03

    Effect of Methimazole Combined with Levothyroxine on the Thyroid Volume and Serum FT3, FT4, TSH Levels of Patients with Hyperthyroidism

    TANG Zhi-feng

    Department of Internal Medicine, Tongzhou District Eighth People’s Hospital, Nantong, Jiangsu Province, 226361 China

    [Abstract] Objective To know the effect of methimazole combined with levothyroxine on the thyroid volume and serum FT3, FT4, TSH levels of patients with hyperthyroidism. Methods 68 cases of patients with hyperthyroidism admitted and treated in our hospital from January 2014 to December 2016 were convenient selected and randomly divided into two groups with 34 cases in each, the control group were treated with methimazole, while the treatment group were treated with methimazole combined with levothyroxine, and the treatment effect was compared between the two groups. Results The thyroid volume in the treatment group was lower than that in the control group, [(12.35±4.60) mL vs (15.62±3.61) mL],(t=-3.261; P<0.05), and the serum FT3(4.42±1.52) pg/mL(t=5.308; P<0.05), FT4( 13.49±1.16)mmol/L(t=7.071; P<0.05) were higher than those in the control group, [(3.11±0.69)pg/mL, (11.20±1.49) mmol/L](P<0.05), and the TSH level was lower than that in the control group, [( 2.65±1.21) mIU/L vs (4.21±1.24)mIU/L], (t=-5.250;P<0.05). Conclusion The methimazole combined with levothyroxine in treatment of hyperthyroidism can ensure the decrease of thyroid volume, and better improve the serum FT3, FT4, TSH levels, with higher clinical promotion value.

    [Key words] Methimazole; Levothyroxine; Hyperthyroidism

    甲状腺功能亢进症(甲亢)是临床较常见疾病之一,主要因机体甲状腺分泌过多甲状腺激素而伴发的一种甲状腺毒症,对机体循环系统、循环系统、神经系统等均会造成嚴重影响[1]。现阶段,弥漫性甲状腺肿合并甲亢在甲亢中发病率相对高,患病后易损伤患者的肝脏、心等器官,若病情发展严重且未得到及时治疗,则会严重威胁患者生命安全。因此,该院近年来通过甲巯咪唑、左甲状腺素片联用的方案对甲状腺功能亢进症患者实施治疗[2]。该次研究将该院2014年1月—2016年12月收治的68例甲状腺功能亢进症患者分为两组,分别以甲巯咪唑、联用甲巯咪唑与左甲状腺素片的方案展开治疗,现报道如下。, 百拇医药(汤志锋)
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