血清总胆红素联合溶血三项试验检测在新生儿溶血病早期诊治中的应用(1)
[摘要] 目的 探讨血清总胆红素联合溶血三项试验检测在新生儿溶血病早期诊治中的应用。方法 随机选取该院2016年8月—2018年1月接收的88例新生儿溶血病患儿为该次实验研究对象，所有患儿均给予血清总胆红素联合溶血三项试验检测，比较血清总胆红素联合溶血三项试验检测与单纯溶血三项检测对新生儿溶血病早期检出情况。结果 血清总胆红素联合溶血三项试验新生儿溶血病早期阳性检出率明显高于单纯溶血三项检测阳性检出率(85.2% vs 97.7%)，单纯溶血三项检测中释放试验中释放试验(+)且游离试验(+)患儿所占比例最多，数据差异有统计学意义(P<0.05)。结论 对于新生儿溶血患儿给予血清总胆红素联合溶血三项检测可有效提高检出率。
[关键词] 血清总胆红素；溶血三项试验检测；新生儿溶血病；早期诊治
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2018)07(a)-0048-03
Application of Serum Total Bilirubin Combined with Hemolysis in the Early Diagnosis and Treatment of Hemolytic Disease of the Newborn
XIANG Hong-liang， ZHANG Shu-guang
Department of Blood Transfusion， People's Hospital of Tongren， Tongren， Guizhou Province， 554300 China
[Abstract] Objective This paper tries to explore the application of serum total bilirubin combined with hemolysis in the early diagnosis and treatment of hemolytic disease. Methods 88 neonatal hemolytic patients received from the hospital from August 2016 to January 2018 were randomly selected as the experimental study subjects. All the patients were given serum total bilirubin combined hemolysis three tests to compare serum total detection of the hemolytic disease of newborns was detected by the three tests of bilirubin combined with hemolysis and the three tests of hemolysis alone. Results The positive rate of early detection of neonatal hemolytic disease in serum total bilirubin combined with hemolysis was significantly higher than that of pure hemolysis (85.2% vs 97.7%)， and release from release trials of pure hemolysis was only three items. The proportion of children with test (+) and free test (+) was the highest， and the difference was statistically significant (P<0.05). Conclusion The detection of serum total bilirubin combined with hemolysis in neonates with hemolysis can effectively increase the detection rate.
[Key words] Serum total bilirubin； Hemolytic three tests； Newborn hemolytic disease； Early diagnosis and treatment
新生儿溶血病的发生主要原因是母亲血型与婴儿血型不合，其中临床常见的为Rh血型不合以及ABO血型不合，患兒主要临床症状为肝脾肿大、黄疸，若未及时诊断并给予有效治疗病情严重可诱发胆红素脑病，严重威肋患儿生命健康[1]。目前临床上诊断新生儿溶血病的主要检测方式为溶血三项试验，但是近些年相关研究学者提出血清总胆红素含量对评估新生儿溶血病也具有重要的诊断价值[2]。该次研究对该院2016年8月—2018年1月接收的88例新生儿溶血病患儿均给予血清总胆红素联合溶血三项试验检测，通过比较血清总胆红素联合溶血三项试验检测与单纯溶血三项检测新生儿溶血病阳性检出情况，从而论证血清总胆红素联合溶血三项试验检测在新生儿溶血病早期诊治中的应用价值，现报道如下。
1 资料与方法
1.1 一般资料
随机选取该院接收的88例新生儿溶血病患儿，男55例，女33例，患儿日龄最小为出生后2 h，日龄最大为出生后16 d，平均日龄在(7.1±1.2)d，其中有48例新生儿血型为A型，有40例新生儿血型为B型，参与该次研究的患儿在年龄、性别、血型等一般资料上差异无统计学意义(P>0.05)。, http://www.100md.com(向红亮 张曙光)
[关键词] 血清总胆红素；溶血三项试验检测；新生儿溶血病；早期诊治
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2018)07(a)-0048-03
Application of Serum Total Bilirubin Combined with Hemolysis in the Early Diagnosis and Treatment of Hemolytic Disease of the Newborn
XIANG Hong-liang， ZHANG Shu-guang
Department of Blood Transfusion， People's Hospital of Tongren， Tongren， Guizhou Province， 554300 China
[Abstract] Objective This paper tries to explore the application of serum total bilirubin combined with hemolysis in the early diagnosis and treatment of hemolytic disease. Methods 88 neonatal hemolytic patients received from the hospital from August 2016 to January 2018 were randomly selected as the experimental study subjects. All the patients were given serum total bilirubin combined hemolysis three tests to compare serum total detection of the hemolytic disease of newborns was detected by the three tests of bilirubin combined with hemolysis and the three tests of hemolysis alone. Results The positive rate of early detection of neonatal hemolytic disease in serum total bilirubin combined with hemolysis was significantly higher than that of pure hemolysis (85.2% vs 97.7%)， and release from release trials of pure hemolysis was only three items. The proportion of children with test (+) and free test (+) was the highest， and the difference was statistically significant (P<0.05). Conclusion The detection of serum total bilirubin combined with hemolysis in neonates with hemolysis can effectively increase the detection rate.
[Key words] Serum total bilirubin； Hemolytic three tests； Newborn hemolytic disease； Early diagnosis and treatment
新生儿溶血病的发生主要原因是母亲血型与婴儿血型不合，其中临床常见的为Rh血型不合以及ABO血型不合，患兒主要临床症状为肝脾肿大、黄疸，若未及时诊断并给予有效治疗病情严重可诱发胆红素脑病，严重威肋患儿生命健康[1]。目前临床上诊断新生儿溶血病的主要检测方式为溶血三项试验，但是近些年相关研究学者提出血清总胆红素含量对评估新生儿溶血病也具有重要的诊断价值[2]。该次研究对该院2016年8月—2018年1月接收的88例新生儿溶血病患儿均给予血清总胆红素联合溶血三项试验检测，通过比较血清总胆红素联合溶血三项试验检测与单纯溶血三项检测新生儿溶血病阳性检出情况，从而论证血清总胆红素联合溶血三项试验检测在新生儿溶血病早期诊治中的应用价值，现报道如下。
1 资料与方法
1.1 一般资料
随机选取该院接收的88例新生儿溶血病患儿，男55例，女33例，患儿日龄最小为出生后2 h，日龄最大为出生后16 d，平均日龄在(7.1±1.2)d，其中有48例新生儿血型为A型，有40例新生儿血型为B型，参与该次研究的患儿在年龄、性别、血型等一般资料上差异无统计学意义(P>0.05)。, http://www.100md.com(向红亮 张曙光)