普宁地区免费孕前优生健康检查梅毒筛查干预模式的研究(1)
[摘要] 目的 探讨普宁地区育龄妇女孕前优生健康检查梅毒筛查干预模式在降低出生缺陷，提高孕育质量的作用评估。 方法 回顾性分析普宁地区2012—2016年间12 420名参加国家免费孕前优生健康检查的育龄妇女的临床资料，分析其梅毒筛查的实验室结果以及对梅毒患者的治疗状况，并随访所生育后代的健康状况，评估梅毒筛查干预模式在降低出生缺陷，提高孕育质量的作用。 结果12 420名育龄妇女的梅毒筛查结果为：梅毒螺旋体抗体(胶体金法)检测52例阳性，初筛阳性率为0.42%；将初筛阳性的样本再进行梅毒甲苯胺红不加热血清试验(TRUST)检测确诊44例阳性，阳性率为0.35%。经过干预治疗后，44例梅毒患者中有39例患者在随访期间有生育后代，子代中均未发现梅毒携带或感染病例。 结论 免费孕前优生健康检查对优生优育具有重要意义，孕前进行必要的梅毒筛查并进行干预是提高人口素质，降低出生缺陷的有效手段，值得推广。
[关键词] 梅毒；孕前优生；普宁
[中图分类号] R169.1；R759.1 [文献标识码] A [文章编号] 1674-0742(2018)11(a)-0069-03
[Abstract] Objective To investigate the effect of syphilis screening intervention mode on reducing birth defects and improving the quality of gestation in women of childbearing age in Puning area. Methods The clinical data of 12 420 women of childbearing age who participated in the national free pre-pregnancy eugenics examination in Puning area from 2012 to 2016 were retrospectively analyzed. The laboratory results of syphilis screening and the treatment status of syphilis patients were analyzed， and the health of the offspring was followed up， assess the role of syphilis screening intervention mode in reducing birth defects and improving the quality of gestation. Results The results of syphilis screening in 12 420 women of childbearing age were as follows： 52 cases of syphilis antibody (colloidal gold method) were positive， and the initial screening rate was 0.42%. The samples with positive screening were further tested with syphilis toluidine red unheated serum(TRUST) was confirmed to be positive in 44 cases， with a positive rate of 0.35%. After intervention， 39 of the 44 patients with syphilis had fertility offspring during the follow-up period， and no syphilis carriers or infections were found in the offspring. Conclusion The free pre-pregnancy eugenics health check is of great significance for prenatal and postnatal care. Performing necessary syphilis screening and intervention before pregnancy is an effective means to improve the quality of the population and reduce birth defects. It is worth promoting.
[Key words] Syphilis； Pre-pregnancy eugenics； Puning
自國家2010年全面启动免费孕前优生健康检查项目以来，育龄妇女孕前生殖健康状况得到了有效的评估，对于预防出生缺陷和提高出生人口素质和国民整体健康水平有着重要的意义。普宁地区惯切落实国家免费孕前优生健康检查政策，充分发挥生育健康服务网络优势，全面实施梅毒检查，对该地区2012—2016年间12 420名育龄妇女进行集中筛查、规范干预、定期随访，在预防梅毒传播，降低出生缺陷方面取得了良好效果，现报道如下。
1 资料与方法
1.1 一般资料
检查对象整群选择为普宁地区2012—2016年间12 420名参加国家免费孕前优生健康检查的育龄妇女。年龄在21～36岁间，平均年龄(26.85±4.12)岁；户籍人员10 864人，流动人员1 556人；初婚生育11 355人，再婚生育1 065人。梅毒确诊对象与正常育龄妇女在年龄、户籍、婚育状况等一般人口学资料方面相互比较，差异无统计学意义(P>0.05)，见表1、表2。, http://www.100md.com(方培群 陈泽伟 陈圳伟 姚清娇 杨宗明 杨丽斌 江翠虹 黄银屏)
[关键词] 梅毒；孕前优生；普宁
[中图分类号] R169.1；R759.1 [文献标识码] A [文章编号] 1674-0742(2018)11(a)-0069-03
[Abstract] Objective To investigate the effect of syphilis screening intervention mode on reducing birth defects and improving the quality of gestation in women of childbearing age in Puning area. Methods The clinical data of 12 420 women of childbearing age who participated in the national free pre-pregnancy eugenics examination in Puning area from 2012 to 2016 were retrospectively analyzed. The laboratory results of syphilis screening and the treatment status of syphilis patients were analyzed， and the health of the offspring was followed up， assess the role of syphilis screening intervention mode in reducing birth defects and improving the quality of gestation. Results The results of syphilis screening in 12 420 women of childbearing age were as follows： 52 cases of syphilis antibody (colloidal gold method) were positive， and the initial screening rate was 0.42%. The samples with positive screening were further tested with syphilis toluidine red unheated serum(TRUST) was confirmed to be positive in 44 cases， with a positive rate of 0.35%. After intervention， 39 of the 44 patients with syphilis had fertility offspring during the follow-up period， and no syphilis carriers or infections were found in the offspring. Conclusion The free pre-pregnancy eugenics health check is of great significance for prenatal and postnatal care. Performing necessary syphilis screening and intervention before pregnancy is an effective means to improve the quality of the population and reduce birth defects. It is worth promoting.
[Key words] Syphilis； Pre-pregnancy eugenics； Puning
自國家2010年全面启动免费孕前优生健康检查项目以来，育龄妇女孕前生殖健康状况得到了有效的评估，对于预防出生缺陷和提高出生人口素质和国民整体健康水平有着重要的意义。普宁地区惯切落实国家免费孕前优生健康检查政策，充分发挥生育健康服务网络优势，全面实施梅毒检查，对该地区2012—2016年间12 420名育龄妇女进行集中筛查、规范干预、定期随访，在预防梅毒传播，降低出生缺陷方面取得了良好效果，现报道如下。
1 资料与方法
1.1 一般资料
检查对象整群选择为普宁地区2012—2016年间12 420名参加国家免费孕前优生健康检查的育龄妇女。年龄在21～36岁间，平均年龄(26.85±4.12)岁；户籍人员10 864人，流动人员1 556人；初婚生育11 355人，再婚生育1 065人。梅毒确诊对象与正常育龄妇女在年龄、户籍、婚育状况等一般人口学资料方面相互比较，差异无统计学意义(P>0.05)，见表1、表2。, http://www.100md.com(方培群 陈泽伟 陈圳伟 姚清娇 杨宗明 杨丽斌 江翠虹 黄银屏)