醒脑静注射液联合依达拉奉在脑出血患者中的临床应用及对患者生活质量的影响(1)
[摘要] 目的 分析脑出血患者采用醒脑静注射液联合依达拉奉治疗的临床疗效以及对患者生活质量产生的影响。方法 2016年2月—2018年3月，于该院收治的急性脑出血患者中方便选取94例，随机分为两组，对照组患者47例，单独采用依达拉奉治疗，观察组患者47例，采用醒脑静注射液联合依达拉奉治疗，对比两组患者治疗前后ADL(日常生活能力)、NIHSS(神经功能缺损)、生活质量变化情况。结果 观察组治疗后ADL评分为(92.25±7.25)分，高于对照组的(70.05±12.08)分，NIHSS评分为(12.05±5.32)分，低于对照组的(19.08±4.22)分，差异有统计学意义(t=15.625 5、16.669 8，P<0.05);与对照组对比，观察组治疗后各项生活质量评分更高，组间差异有统计学意义(P<0.05)。 结论 脑出血患者采用醒脑静注射液联合依达拉奉治疗的临床疗效显著，能有效改善患者的生活质量，值得推广。
[关键词] 醒脑静注射液;脑出血;依达拉奉;联合治疗;临床疗效;生活质量
[中图分类号] R743.34 [文献标识码] A [文章编号] 1674-0742(2018)12(c)-0013-03
[Abstract] Objective To analyze the application of xingnaojing injection combined with edaravone in patients with cerebral hemorrhage and effect on the quality of life of patients. Methods 94 cases of patients with acute cerebral hemorrhage admitted and treated in our hospital from February 2016 to March 2018 were conveniently selected and randomly divided into two groups with 47 cases in each， the control group were treated with single edaravone， while the observation group used the xingnaojing injection combined with edaravone， and the ADL， NIHSS and changes of quality of life were compared before and after treatment. Results After treatment， the ADL score in the observation group was higher than that in the control group， [(92.25±7.25)pointss vs (70.05±12.08)points]， and the NIHSS score was lower than that in the control group， [(12.05±5.32) points vs (19.08±4.22)points，the different was statistically significant(t=15.625 5， 16.669 8， P<0.05)， and various quality of life scores after treatment in the observation group was higher， and the differences between groups were statistically significant(P<0.05). Conclusion The clinical curative effect of xingnaojing injection combined with edaravone in patients with cerebral hemorrhage is obvious， which can effectively improve the quality of life， and it is worth promotion.
[Key words] Xingnaojing injection; Cerebral hemorrhage; Edaravone; Combined therapy; Clinical curative effect; Quality of life
急性腦出血发生之后，会促使脑内血肿向周围正常组织进行压迫，进而造成脑细胞局部缺氧缺血，出现脑损伤现象，引发炎性免疫反应[1]。当患者病情处于急性期时，治疗的关键在于保持安静状态，对脑出血进行有效防治;行积极抗脑水肿治疗，将颅内压降低;对血压水平进行调整，促使循环得到改善[2]。据近年来的病理研究可知，缺血所致脑损害的一个重要发病机制为自由基所致脑组织损害，故临床上加强了对自由基清除剂的研究[3-4]。依达拉奉属于自由基清除剂的一种，能将脑出血和脑水肿进展阻断，但在促进患者神经功能恢复方面的作用较为有限[5-6]。醒脑静注射液则能对炎性细胞因子过度释放进行干预，促进神经功能恢复。为了进一步提高脑出血患者的临床疗效，改善预后，该研究于2016年2月—2018年3月方便选取47例患者在该疾病治疗中联合应用依达拉奉与醒脑静注射液，获得了理想的临床疗效，现报道如下。
1 资料与方法, http://www.100md.com(梅远伦)
[关键词] 醒脑静注射液;脑出血;依达拉奉;联合治疗;临床疗效;生活质量
[中图分类号] R743.34 [文献标识码] A [文章编号] 1674-0742(2018)12(c)-0013-03
[Abstract] Objective To analyze the application of xingnaojing injection combined with edaravone in patients with cerebral hemorrhage and effect on the quality of life of patients. Methods 94 cases of patients with acute cerebral hemorrhage admitted and treated in our hospital from February 2016 to March 2018 were conveniently selected and randomly divided into two groups with 47 cases in each， the control group were treated with single edaravone， while the observation group used the xingnaojing injection combined with edaravone， and the ADL， NIHSS and changes of quality of life were compared before and after treatment. Results After treatment， the ADL score in the observation group was higher than that in the control group， [(92.25±7.25)pointss vs (70.05±12.08)points]， and the NIHSS score was lower than that in the control group， [(12.05±5.32) points vs (19.08±4.22)points，the different was statistically significant(t=15.625 5， 16.669 8， P<0.05)， and various quality of life scores after treatment in the observation group was higher， and the differences between groups were statistically significant(P<0.05). Conclusion The clinical curative effect of xingnaojing injection combined with edaravone in patients with cerebral hemorrhage is obvious， which can effectively improve the quality of life， and it is worth promotion.
[Key words] Xingnaojing injection; Cerebral hemorrhage; Edaravone; Combined therapy; Clinical curative effect; Quality of life
急性腦出血发生之后，会促使脑内血肿向周围正常组织进行压迫，进而造成脑细胞局部缺氧缺血，出现脑损伤现象，引发炎性免疫反应[1]。当患者病情处于急性期时，治疗的关键在于保持安静状态，对脑出血进行有效防治;行积极抗脑水肿治疗，将颅内压降低;对血压水平进行调整，促使循环得到改善[2]。据近年来的病理研究可知，缺血所致脑损害的一个重要发病机制为自由基所致脑组织损害，故临床上加强了对自由基清除剂的研究[3-4]。依达拉奉属于自由基清除剂的一种，能将脑出血和脑水肿进展阻断，但在促进患者神经功能恢复方面的作用较为有限[5-6]。醒脑静注射液则能对炎性细胞因子过度释放进行干预，促进神经功能恢复。为了进一步提高脑出血患者的临床疗效，改善预后，该研究于2016年2月—2018年3月方便选取47例患者在该疾病治疗中联合应用依达拉奉与醒脑静注射液，获得了理想的临床疗效，现报道如下。
1 资料与方法, http://www.100md.com(梅远伦)