血尿酸水平与冠心病相关性研究(1)
[摘要] 目的 探讨血尿酸水平与冠心病的相关性，为冠心病的诊疗提供参考。方法 方便选取该院心内科自2016年5月—2017年5月收治的40例经冠脉造影确诊的40例冠心病患者作为观察组，同期接受体检的40名健康人作为对照组，比较分析两组血清尿酸水平差异。 结果 观察组内单支病变亚组25例，双支病变亚组12例，三支病变亚组3例；观察组治疗前血尿酸水平(345.29±30.16)mmol/L，明显高于对照组(301.02±25.48)mmol/l，组间比较差异有统计学意义(t=7.091，P=0.000)；观察组内随着病变冠状动脉数的增加，患者血尿酸水平呈现出上升趋势相关因素分析显示，血尿酸水平冠状动脉狭窄指数之间呈正相关关系(OR=0.872，P=0.008)，Logistic多因素回归分析结果显示，血尿酸水平与年龄、糖尿病病史一起共为冠心病的危险因素(P<0.05)。 结论 血尿酸水平与冠心病的发生、发展之间关系密切，为冠心病独立危险因素之一。
[关键词] 血尿酸；冠心病；相关性
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742(2019)01(c)-0074-03
Correlation between Serum Uric Acid Level and Coronary Heart Disease
YAN Min
Department of Cardiopulmonary， Yixing Hospital of Traditional Chinese Medicine， Yixing， Jiangsu Province， 214200 China
[Abstract] Objective To investigate the relationship between serum uric acid level and coronary heart disease， and to provide reference for the diagnosis and treatment of coronary heart disease. Methods 40 patients with coronary heart disease who were diagnosed by coronary angiography from May 2016 to May 2017 were convenient selected enrolled in the study group. 40 healthy people who underwent physical examination at the same time were regarded as the control group. The difference in serum uric acid levels were compared. Results In the observation group， 25 cases of single-vessel disease subgroup， 12 cases of double-vessel disease sub-group， and 3 cases of three-vessel disease sub-group； the blood uric acid level (345.29±30.16) mmol/L in the observation group was significantly higher than that of the control group (301.02±25.48)mmol/l， the difference between the two groups was statistically significant (t=7.091， P=0.000). In the observation group， the blood uric acid level showed an upward trend with the increase of the number of coronary artery lesions. There was a positive correlation between blood uric acid level and coronary artery stenosis index (OR=0.872， P=0.008). Logistic multivariate regression analysis showed that blood uric acid level was associated with age and diabetes history as a risk factor for coronary heart disease (P<0.05). Conclusion The relationship between serum uric acid level and the occurrence and development of coronary heart disease is one of the independent risk factors for coronary heart disease.
[Key words] Blood uric acid； Coronary heart disease； Correlation
冠心病為冠状动脉硬化导致心肌缺氧、缺血所引起的心脏疾病，近年来该病发生率逐年上升，并成为威胁居民安全的社会公共卫生问题[1]。随着研究的不断深入，临床已经确认本病发生与年龄、不良生活方式、性别、吸烟、高血压、糖尿病等多因素有关，并主张针对上述因素采取积极的应对措施，以预防冠心病的发生[2]。随着研究不断深入，有学者研究发现高尿酸血症与上述危险因素之间相关联，且血尿酸在冠心病的的发生、发展中均有参与，因此血尿酸与冠心病关系、其在冠心病中的作用机制等逐渐成为临床研究的重点与热点。为验证血尿酸水平与冠心病之间的相关性，对该院心内科自2016年5月—2017年5月收治的40例冠心病患者作为研究对象，并就其血尿酸水平与健康人比较，现将具体报告如下。, 百拇医药(颜闵)
[关键词] 血尿酸；冠心病；相关性
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742(2019)01(c)-0074-03
Correlation between Serum Uric Acid Level and Coronary Heart Disease
YAN Min
Department of Cardiopulmonary， Yixing Hospital of Traditional Chinese Medicine， Yixing， Jiangsu Province， 214200 China
[Abstract] Objective To investigate the relationship between serum uric acid level and coronary heart disease， and to provide reference for the diagnosis and treatment of coronary heart disease. Methods 40 patients with coronary heart disease who were diagnosed by coronary angiography from May 2016 to May 2017 were convenient selected enrolled in the study group. 40 healthy people who underwent physical examination at the same time were regarded as the control group. The difference in serum uric acid levels were compared. Results In the observation group， 25 cases of single-vessel disease subgroup， 12 cases of double-vessel disease sub-group， and 3 cases of three-vessel disease sub-group； the blood uric acid level (345.29±30.16) mmol/L in the observation group was significantly higher than that of the control group (301.02±25.48)mmol/l， the difference between the two groups was statistically significant (t=7.091， P=0.000). In the observation group， the blood uric acid level showed an upward trend with the increase of the number of coronary artery lesions. There was a positive correlation between blood uric acid level and coronary artery stenosis index (OR=0.872， P=0.008). Logistic multivariate regression analysis showed that blood uric acid level was associated with age and diabetes history as a risk factor for coronary heart disease (P<0.05). Conclusion The relationship between serum uric acid level and the occurrence and development of coronary heart disease is one of the independent risk factors for coronary heart disease.
[Key words] Blood uric acid； Coronary heart disease； Correlation
冠心病為冠状动脉硬化导致心肌缺氧、缺血所引起的心脏疾病，近年来该病发生率逐年上升，并成为威胁居民安全的社会公共卫生问题[1]。随着研究的不断深入，临床已经确认本病发生与年龄、不良生活方式、性别、吸烟、高血压、糖尿病等多因素有关，并主张针对上述因素采取积极的应对措施，以预防冠心病的发生[2]。随着研究不断深入，有学者研究发现高尿酸血症与上述危险因素之间相关联，且血尿酸在冠心病的的发生、发展中均有参与，因此血尿酸与冠心病关系、其在冠心病中的作用机制等逐渐成为临床研究的重点与热点。为验证血尿酸水平与冠心病之间的相关性，对该院心内科自2016年5月—2017年5月收治的40例冠心病患者作为研究对象，并就其血尿酸水平与健康人比较，现将具体报告如下。, 百拇医药(颜闵)