清利湿热方联合光动力疗法治疗糜烂型口腔扁平苔藓的疗效探讨(1)
[摘要] 目的 探讨清利湿热方联合光动力疗法治疗糜烂型口腔扁平苔藓的临床疗效。方法 便利抽取2015年8月—2017年8月在该院进行医治的糜烂型口腔扁平苔藓患者126例，均等划分为A组和B组，每组63例。A组患者采取光动力疗法进行治疗；B组患者则采用清利湿热方联合光动力疗法进行治疗。观察并比较两组患者的疼痛评分和体征评分、炎症因子水平、临床疗效、不良反应发生情况和复发率。结果 治疗后，B组患者的疼痛评分、体征评分分别为(2.16±0.13)分、(0.88±0.13)分，A组患者的疼痛评分、体征评分分别为(4.97±0.28)分、(2.52±0.27)分，B组患者的改善程度明显好于A组，差异有统计学意义(t=63.17，40.41；P< 0.05)；A组患者的治疗总有效率为81.67%，B组患者的治疗总有效率为95.93%，B组患者的治疗总有效率明显高于A组，差异有统计学意义(χ2=4.179，P<0.05)；对两组患者治疗后的不良反应和复发率进行比较发现，A组患者治疗后有11例(17.46%)复发，B组患者治疗后有2例(3.17%)复发，差异有统计学意义(χ2=4.64，P=0.02)。结论 采用清利濕热方联合光动力疗法对糜烂型口腔扁平苔藓患者进行治疗有较好的临床效果，能够显著改善患者的疼痛和体征、降低患者血清炎症因子水平，且不良反应和复发率较低，值得临床推广应用。
[关键词] 清利湿热方；光动力疗法；糜烂型口腔扁平苔藓；疗效观察
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2019)02(c)-0019-03
[Abstract] Objective To investigate the clinical efficacy of Qingli damp heat combined with photodynamic therapy in the treatment of erosive oral lichen planus. Methods A total of 126 patients with erosive oral lichen planus who were treated in our hospital from August 2015 to August 2017 were convenient selected and randomly divided into group A and group B， with 63 in each group. Patients in group A were treated with photodynamic therapy； patients in group B were treated with clearing dampness and heat combined with photodynamic therapy. The pain score and physical score， inflammatory factor level， clinical efficacy， adverse reaction occurrence and recurrence rate were observed and compared between the two groups. Results After treatment， the pain scores and physical scores of group B patients were (2.16±0.13) points and (0.88±0.13) points respectively. The pain scores and physical scores of group A patients were (4.97±0.28) points， respectively (2.52±0.27)points， the improvement of patients in group B was significantly better than that in group A ， the difference was statistically significant(t=63.17， 40.41； P<0.05)； the total effective rate of treatment in group A was 81.67%， and the total effective rate in group B was 95.93%. The total effective rate of patients in group B was significantly higher than that in group A，the difference was statistically significant(χ2=4.179， P<0.05). Comparing the adverse reactions and recurrence rates after treatment in group B， 11 patients in group A after treatment had recurrence (17.46%)， and 2 patients (3.17%) relapsed after treatment in group B，the difference was statistically significant(χ2=4.64， P=0.02). Conclusion Qingli damp heat combined with photodynamic therapy has a good clinical effect on the treatment of patients with erosive oral lichen planus. It can significantly improve the pain and signs of patients， reduce the serum inflammatory factor levels， and the adverse reactions and recurrence rates were lower， worthy of clinical application., 百拇医药(刘为玲)
[关键词] 清利湿热方；光动力疗法；糜烂型口腔扁平苔藓；疗效观察
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2019)02(c)-0019-03
[Abstract] Objective To investigate the clinical efficacy of Qingli damp heat combined with photodynamic therapy in the treatment of erosive oral lichen planus. Methods A total of 126 patients with erosive oral lichen planus who were treated in our hospital from August 2015 to August 2017 were convenient selected and randomly divided into group A and group B， with 63 in each group. Patients in group A were treated with photodynamic therapy； patients in group B were treated with clearing dampness and heat combined with photodynamic therapy. The pain score and physical score， inflammatory factor level， clinical efficacy， adverse reaction occurrence and recurrence rate were observed and compared between the two groups. Results After treatment， the pain scores and physical scores of group B patients were (2.16±0.13) points and (0.88±0.13) points respectively. The pain scores and physical scores of group A patients were (4.97±0.28) points， respectively (2.52±0.27)points， the improvement of patients in group B was significantly better than that in group A ， the difference was statistically significant(t=63.17， 40.41； P<0.05)； the total effective rate of treatment in group A was 81.67%， and the total effective rate in group B was 95.93%. The total effective rate of patients in group B was significantly higher than that in group A，the difference was statistically significant(χ2=4.179， P<0.05). Comparing the adverse reactions and recurrence rates after treatment in group B， 11 patients in group A after treatment had recurrence (17.46%)， and 2 patients (3.17%) relapsed after treatment in group B，the difference was statistically significant(χ2=4.64， P=0.02). Conclusion Qingli damp heat combined with photodynamic therapy has a good clinical effect on the treatment of patients with erosive oral lichen planus. It can significantly improve the pain and signs of patients， reduce the serum inflammatory factor levels， and the adverse reactions and recurrence rates were lower， worthy of clinical application., 百拇医药(刘为玲)