联合检测血清SCC、CEA、CA125、CA199在宫颈癌诊断中的价值(1)
[摘要] 目的 分析和探讨联合检测血清SCC、CEA、CA125、CA199在宫颈癌诊断中的应用价值。 方法 该实验于2017年1月—2018年6月在该院进行，以方便选取此时段内收治的40例宫颈癌患者为研究组，并选择同时期健康检查者40例为参照组，检查两组患者SCC、CEA、CA125、CA199浓度，并探讨其在宫颈癌诊断中的应用价值。 结果 研究组患者SCC、CEA、CA125、CA199水平明显要高于参照组(t=6.866 6，P=0.000 0，t=8.976 9，P=0.000 0，t=11.352 4，P=0.000 0，t=12.257 4，P=0.000 0)，并且联合监测灵敏度明显要高于单独检测，组间所存差异对比，SCC、CEA、CA125、CA199单独检测的灵敏度分别为72.5%、62.5%、60.0%、65.0%，联合检测的为95.0%，差异有统计学意义(χ2=6.155，P=0.024、χ2=1.017，P=0.035、χ2=8.224，P=0.038、χ2=4.996，P=0.015，χ2=15.369，P=0.044)。结论 对于宫颈癌的患者，联合检测血清SCC、CEA、CA125、CA199，可以提高宫颈癌诊断敏感性，效果显著，值得在今后的临床诊断治疗中应用。
[关键词] 宫颈癌；SCC；CEA；CA125；CA199；诊断价值
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-0742(2019)03(a)-0184-03
[Abstract] Objective To analyze and explore the value of combined detection of serum SCC， CEA， CA125 and CA199 in the diagnosis of cervical cancer. Methods This experiment was conducted in our hospital from January 2017 to June 2018. 40 patients with cervical cancer admitted to this period were convenient selected as the study group， and 40 patients with concurrent health examinations were selected as the reference group. Patients with SCC， CEA， CA125， CA199 concentrations， and explore its application value in the diagnosis of cervical cancer. Results The levels of SCC， CEA， CA125 and CA199 in the study group were significantly higher than those in the reference group(t=6.866 6， P=0.000 0， t=8.976 9， P=0.000 0，t=11.352 4， P=0.000 0，t=12.257 4， P=0.000 0)， and the combined monitoring sensitivity was significantly higher than the individual detection， the difference between the groups， SCC， CEA， CA125， CA199 alone sensitivity of the detection was 72.5%，62.5%，60.0/%，65.0%，and the combined detection was 95.0%. The difference was statistically significant(χ2=6.155， P=0.024，χ2=1.017， P=0.035，χ2= 8.224， P=0.038，χ2=4.996， P=0.015 χ2=15.369， P=0.044). Conclusion For patients with cervical cancer， combined detection of serum SCC， CEA， CA125， CA199 can improve the diagnostic sensitivity of cervical cancer， and the effect is significant， which is worthy of application in future clinical diagnosis and treatment.
[Key words] Cervical cancer； SCC； CEA； CA125； CA199； Diagnostic value
宫颈癌作为较为常见的女性恶性肿瘤，在我国宫颈癌的发生率仅次于乳腺癌。在临床上，多以SCC、CEA、CA125、CA199作为宫颈癌诊断标准，运用单独检测方式无法实现有效诊断，通过联合运用的方式可以进一步提高诊断率。为此该次研究于2017年1月—2018年6月在该院进行，以此时段内收治的40例宫颈癌患者为研究组，并选择同时期健康检查者40名为参照组，通过对联合检测血清SCC、CEA、CA125、CA199在宫颈癌诊断中的应用，观察和探讨其与宫颈癌之间存在的病理关系，也为临床上提供诊断依据，取得了很好的效果，报道如下。
1 资料与方法
1.1 一般资料
方便选取该院收治的40例宫颈癌患者作为研究组，并选择同时期健康检查者40名为参照组，研究组中患者年龄介于28～72岁之间，(51.2±3.4)岁为平均年龄，参照组中患者年龄处于28～76岁之间，(54.3±3.7)岁为平均年龄。其中宫颈癌病理类型为：宫颈腺癌18例，宫颈鳞癌22例。对比两组患者基本资料，差异无统计学意义(P>0.05)。所有患者都符合宫颈癌的诊断标准。经过伦理委员会批准，经过患者家屬同意。排除有沟通障碍的，排除资料不全的患者。, http://www.100md.com(唐蕾)
[关键词] 宫颈癌；SCC；CEA；CA125；CA199；诊断价值
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-0742(2019)03(a)-0184-03
[Abstract] Objective To analyze and explore the value of combined detection of serum SCC， CEA， CA125 and CA199 in the diagnosis of cervical cancer. Methods This experiment was conducted in our hospital from January 2017 to June 2018. 40 patients with cervical cancer admitted to this period were convenient selected as the study group， and 40 patients with concurrent health examinations were selected as the reference group. Patients with SCC， CEA， CA125， CA199 concentrations， and explore its application value in the diagnosis of cervical cancer. Results The levels of SCC， CEA， CA125 and CA199 in the study group were significantly higher than those in the reference group(t=6.866 6， P=0.000 0， t=8.976 9， P=0.000 0，t=11.352 4， P=0.000 0，t=12.257 4， P=0.000 0)， and the combined monitoring sensitivity was significantly higher than the individual detection， the difference between the groups， SCC， CEA， CA125， CA199 alone sensitivity of the detection was 72.5%，62.5%，60.0/%，65.0%，and the combined detection was 95.0%. The difference was statistically significant(χ2=6.155， P=0.024，χ2=1.017， P=0.035，χ2= 8.224， P=0.038，χ2=4.996， P=0.015 χ2=15.369， P=0.044). Conclusion For patients with cervical cancer， combined detection of serum SCC， CEA， CA125， CA199 can improve the diagnostic sensitivity of cervical cancer， and the effect is significant， which is worthy of application in future clinical diagnosis and treatment.
[Key words] Cervical cancer； SCC； CEA； CA125； CA199； Diagnostic value
宫颈癌作为较为常见的女性恶性肿瘤，在我国宫颈癌的发生率仅次于乳腺癌。在临床上，多以SCC、CEA、CA125、CA199作为宫颈癌诊断标准，运用单独检测方式无法实现有效诊断，通过联合运用的方式可以进一步提高诊断率。为此该次研究于2017年1月—2018年6月在该院进行，以此时段内收治的40例宫颈癌患者为研究组，并选择同时期健康检查者40名为参照组，通过对联合检测血清SCC、CEA、CA125、CA199在宫颈癌诊断中的应用，观察和探讨其与宫颈癌之间存在的病理关系，也为临床上提供诊断依据，取得了很好的效果，报道如下。
1 资料与方法
1.1 一般资料
方便选取该院收治的40例宫颈癌患者作为研究组，并选择同时期健康检查者40名为参照组，研究组中患者年龄介于28～72岁之间，(51.2±3.4)岁为平均年龄，参照组中患者年龄处于28～76岁之间，(54.3±3.7)岁为平均年龄。其中宫颈癌病理类型为：宫颈腺癌18例，宫颈鳞癌22例。对比两组患者基本资料，差异无统计学意义(P>0.05)。所有患者都符合宫颈癌的诊断标准。经过伦理委员会批准，经过患者家屬同意。排除有沟通障碍的，排除资料不全的患者。, http://www.100md.com(唐蕾)