食管鳞状细胞癌单纯手术与术后放疗临床疗效及预后因素的回顾性对比分析(1)
[摘要] 目的 回顧性研究单纯手术与术后放疗对食管鳞状细胞癌(Esophageal squamous cell carcinoma， ESCC)的临床疗效及预后影响因素。 方法 该院收治的2006年1月—2013年6月接受Ivor-Lewis根治术的Ⅱb～Ⅲc期ESCC患者202名，其中单纯手术者81例，术后放疗者121例，比较两组的生存时间、生存率、复发率等因素。 结果 单纯手术组的中位生存时间为31个月，术后放疗组为36个月;单纯手术组的1、3、5年的生存率为80%、31%、16%，术后放疗组为78%、42%、27%，总生存率差异无统计学意义(χ2=2.41，P=0.12>0.05)，单纯手术组的1、3、5年的转移率是51%、68%、81%，复发率是52%，术后放疗组的转移率是49%、60%、72%，复发率是33%，差异有统计学意义(χ2=4.49、5.41，P=0.03、0.02)。结论 未发现单纯手术和术后放疗对ESCC的总生存率影响的差异，但术后放疗能提高Ⅱb～Ⅲc期ESCC患者的5年生存率。
[关键词] 食管鳞癌;手术;术后放疗;生存率;预后因素
, 百拇医药
[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-0742(2019)07(a)-0031-03
Retrospective Comparative Analysis of Clinical Efficacy and Prognostic Factors between Esophageal Squamous Cell Carcinoma and Postoperative Radiotherapy
DU Feng， WANG Qiang， SHI Jian， LIU Jia-mei， LENG Chang-jun， DOU Jian-jian， ZHANG Wei
People's Hospital of Linzi， Linzi， Shandong Province， 255400 China
, http://www.100md.com
[Abstract] Objective To retrospectively study the clinical efficacy and prognostic factors of simple surgery and postoperative radiotherapy for esophageal squamous cell carcinoma (ESCC). Methods From January 2006 to June 2013， 202 patients with stage IIb-IIIc ESCC who underwent Ivor-Lewis radical surgery were enrolled in our hospital， including 81 patients with surgery alone and 121 patients with postoperative radiotherapy. The survival time of the two groups was compared， as well as the survival rate， recurrence rate and other factors. Results The median survival time was 31 months in the surgery group alone， 36 months in the postoperative radiotherapy group， and the survival rate in the surgery group was 80%， 31%， and 16% in the first， third， and fifth years. There was no statistically significant difference in overall survival rate between 78%， 42%， and 27% (χ2=2.41， P=0.12>0.05). The 1， 3， and 5-year metastatic rates in the surgery group were 51%， 68%， and 81%， the recurrence rate was 52%， the postoperative radiotherapy group metastasis rate was 49%， 60%， 72%， and the recurrence rate was 33%. The difference was statistically significant (χ2=4.49， 5.41， P=0.03， 0.02). Conclusion There is no difference in the effect of simple surgery and postoperative radiotherapy on the overall survival rate of ESCC， but postoperative radiotherapy can improve the 5-year survival rate of patients with stage IIb to IIIc ESCC.
[Key words] Esophageal squamous cell carcinoma; Surgery; Postoperative radiotherapy; Survival rate; Prognostic factors, http://www.100md.com(杜峰 王强 石健 刘加美 冷昌俊 窦建建 张伟)
[关键词] 食管鳞癌;手术;术后放疗;生存率;预后因素
, 百拇医药
[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-0742(2019)07(a)-0031-03
Retrospective Comparative Analysis of Clinical Efficacy and Prognostic Factors between Esophageal Squamous Cell Carcinoma and Postoperative Radiotherapy
DU Feng， WANG Qiang， SHI Jian， LIU Jia-mei， LENG Chang-jun， DOU Jian-jian， ZHANG Wei
People's Hospital of Linzi， Linzi， Shandong Province， 255400 China
, http://www.100md.com
[Abstract] Objective To retrospectively study the clinical efficacy and prognostic factors of simple surgery and postoperative radiotherapy for esophageal squamous cell carcinoma (ESCC). Methods From January 2006 to June 2013， 202 patients with stage IIb-IIIc ESCC who underwent Ivor-Lewis radical surgery were enrolled in our hospital， including 81 patients with surgery alone and 121 patients with postoperative radiotherapy. The survival time of the two groups was compared， as well as the survival rate， recurrence rate and other factors. Results The median survival time was 31 months in the surgery group alone， 36 months in the postoperative radiotherapy group， and the survival rate in the surgery group was 80%， 31%， and 16% in the first， third， and fifth years. There was no statistically significant difference in overall survival rate between 78%， 42%， and 27% (χ2=2.41， P=0.12>0.05). The 1， 3， and 5-year metastatic rates in the surgery group were 51%， 68%， and 81%， the recurrence rate was 52%， the postoperative radiotherapy group metastasis rate was 49%， 60%， 72%， and the recurrence rate was 33%. The difference was statistically significant (χ2=4.49， 5.41， P=0.03， 0.02). Conclusion There is no difference in the effect of simple surgery and postoperative radiotherapy on the overall survival rate of ESCC， but postoperative radiotherapy can improve the 5-year survival rate of patients with stage IIb to IIIc ESCC.
[Key words] Esophageal squamous cell carcinoma; Surgery; Postoperative radiotherapy; Survival rate; Prognostic factors, http://www.100md.com(杜峰 王强 石健 刘加美 冷昌俊 窦建建 张伟)