丹参多酚酸盐对冠心病心绞痛(心血瘀阻)患者血液流变学的影响(1)
[摘要] 目的 探討丹参多酚酸盐对冠心病心绞痛(心血瘀阻)患者血液流变学的影响。 方法 方便选取该医院2016年1月—2018年6月期间诊治的冠心病心绞痛(心血瘀阻)患者中选取130例作研究对象，均实行药物保守治疗：将采取阿司匹林肠溶片治疗者设为对照组(n=65)将在服用阿司匹林肠溶片基础上加用丹参多酚酸盐治疗者设为研究组(n=65)，就2组患者治疗前后的血液流变学指标、心电图以及中医证候积分变化进行统计学分析。 结果 研究组上述四项血液流变学指标高切全血黏度、低切全血黏度、血浆黏度、红细胞聚集指数均低于对照组(t=7.444、6.508、7.752、14.513，P<0.05); 研究组患者的心电图总有效率95.38%高于对照组的83.08%(χ2=5.123，P=0.024);研究组患者冠心病心绞痛中医证候积分(4.18±0.32)分低于对照组的(8.18±1.24)分(t=25.182，P=0.000)。 结论 丹参多酚酸盐对冠心病心绞痛(心血瘀阻)患者血液流变学有正性影响，在改善患者症候、心电图方面疗效显著，值得借鉴。
, http://www.100md.com [关键词] 丹参多酚酸盐;阿司匹林肠溶片;冠心病心绞痛;心血瘀阻;血液流变学;中医证候;心电图
[中图分类号] R259 [文献标识码] A [文章编号] 1674-0742(2019)07(b)-0098-04
Effect of Salvianolate on Blood Rheology in Patients with Coronary Heart Disease and Angina Pectoris
HUA Dong-fang
Department of Traditional Chinese Medicine， Guanlin Hospital of Yixing City， Yixing， Jiangsu Province， 214251 China
, 百拇医药
[Abstract] Objective To investigate the effect of salvianolate on blood rheology in patients with angina pectoris (cardiac blood stasis). Methods A total of 130 patients with coronary heart disease and angina pectoris (heart and blood stasis) were convenient enrolled in the hospital from January 2016 to June 2018. All patients were treated with conservative treatment： aspirin enteric-coated tablets were used as control group (n=65). The patients who were treated with aspirin and enteric-coated tablets were treated with salvianolate as the study group (n=65)， and the hemorheology， electrocardiogram and TCM syndrome integral changes of the two groups before and after treatment were analyzed. Results The above four blood rheology indexes of the study group showed high whole blood viscosity， low cut whole blood viscosity， plasma viscosity and erythrocyte aggregation index were lower than the control group (t=7.444， 6.508， 7.752， 14.513， P<0.05); The total effective rate of ECG in the study group was 95.38% higher than that in the control group 83.08% (χ2=5.123， P=0.024); The TCM syndrome score of coronary heart disease angina pectoris (4.18±0.32)points was lower than that in the study group of (8.18 ± 1.24) points of the control group (t=25.182， P=0.000). Conclusion Salvianolate has a positive effect on hemorheology in patients with coronary heart disease and angina pectoris. It is worthy of reference for improving the symptoms and electrocardiogram of patients.
[Key words] Salvianolate; Aspirin enteric-coated tablets; Coronary heart disease angina pectoris; Heart and blood stasis; Hemorheology; TCM syndrome; ECG, http://www.100md.com(华东方)
, http://www.100md.com [关键词] 丹参多酚酸盐;阿司匹林肠溶片;冠心病心绞痛;心血瘀阻;血液流变学;中医证候;心电图
[中图分类号] R259 [文献标识码] A [文章编号] 1674-0742(2019)07(b)-0098-04
Effect of Salvianolate on Blood Rheology in Patients with Coronary Heart Disease and Angina Pectoris
HUA Dong-fang
Department of Traditional Chinese Medicine， Guanlin Hospital of Yixing City， Yixing， Jiangsu Province， 214251 China
, 百拇医药
[Abstract] Objective To investigate the effect of salvianolate on blood rheology in patients with angina pectoris (cardiac blood stasis). Methods A total of 130 patients with coronary heart disease and angina pectoris (heart and blood stasis) were convenient enrolled in the hospital from January 2016 to June 2018. All patients were treated with conservative treatment： aspirin enteric-coated tablets were used as control group (n=65). The patients who were treated with aspirin and enteric-coated tablets were treated with salvianolate as the study group (n=65)， and the hemorheology， electrocardiogram and TCM syndrome integral changes of the two groups before and after treatment were analyzed. Results The above four blood rheology indexes of the study group showed high whole blood viscosity， low cut whole blood viscosity， plasma viscosity and erythrocyte aggregation index were lower than the control group (t=7.444， 6.508， 7.752， 14.513， P<0.05); The total effective rate of ECG in the study group was 95.38% higher than that in the control group 83.08% (χ2=5.123， P=0.024); The TCM syndrome score of coronary heart disease angina pectoris (4.18±0.32)points was lower than that in the study group of (8.18 ± 1.24) points of the control group (t=25.182， P=0.000). Conclusion Salvianolate has a positive effect on hemorheology in patients with coronary heart disease and angina pectoris. It is worthy of reference for improving the symptoms and electrocardiogram of patients.
[Key words] Salvianolate; Aspirin enteric-coated tablets; Coronary heart disease angina pectoris; Heart and blood stasis; Hemorheology; TCM syndrome; ECG, http://www.100md.com(华东方)