细胞蜡块对恶性胸腹水的诊断价值(1)
[摘要] 目的 通過对恶性胸腹水实施不同的诊断方法，观察其临床效果，探究不同诊断方法的临床应用特点。 方法 从来该院诊治的2018年7月—2019年2月的晚期肿瘤合并恶性胸腹水患者中随机抽取79例，采用随机数字法随机分为对照组39例：实施常规细胞学检查，观察组40例：实施细胞蜡块检查，观察两组患者检出率和恶性胸腹水上皮肿瘤标志物表达情况。 结果 观察组经过细胞蜡块检查检出例数为30例，检出率为75.00%，对照组经过常规细胞学检查检出例数为20例，检出率为51.28%，观察组检出率高于对照组，差异有统计学意义(χ2=14.442，P<0.05);观察组患者经过细胞蜡块HE染色后背景较为干净，同时，肿瘤细胞异型性明显，呈腺管状和乳头状排列;转移性恶性胸腹水中的moc-31表现敏感，定位明确;在大部分腺癌中CEA具有较高的表达水平，染色背景较重。 结论 细胞蜡块与常规细胞学检查相比，恶性胸腹水患者检出率明显提高，肿瘤病灶来源可以被确定，临床确诊率升高，帮助临床医师做到对症治疗，减少患者痛苦，值得临床推广应用。
[关键词] 细胞蜡块;恶性胸腹水;细胞学检查
, http://www.100md.com
[中图分类号] R730 [文献标识码] A [文章编号] 1674-0742(2019)07(c)-0034-03
Diagnostic Value of Cell Wax Block for Malignant Hydrothorax and Ascites
FAN Hong-yun， HAN Ye， WANG Bei， ZENG Xiang-sheng， LI Ming
Department of Pathology， Xuyi People's Hospital， Xuyi， Jiangsu Province， 211700 China
[Abstract] Objective To observe the clinical effects of different diagnostic methods for malignant hydrothorax and ascites， and to explore the clinical application characteristics of different diagnostic methods. Methods 79 patients with advanced tumors with malignant hydrothorax and ascites from July 2018 to February 2019 were randomly selected from our hospital. They were randomly divided into control group by 39 patients： routine cytology， observation group 40 cases： the cell wax block examination was performed to observe the detection rate of the two groups of patients and the expression of tumor markers in malignant chest and abdomen. Results The number of cases detected by the cell wax block in the observation group was 30， the detection rate was 75.00%， and the number of cases detected by routine cytology in the control group was 20， the detection rate was 51.28%. The detection rate of the observation group higher than the control group，the difference was statistically significant(χ2=14.442， P<0.05). The background of the observation group was clean after HE staining with cell wax block. At the same time， the tumor cells were abnormally shaped， and they were glandular and papillary; metastatic malignant ascites moc-31 is sensitive and well-defined; in most adenocarcinomas， CEA has a higher expression level and a heavier staining background. Conclusion Compared with conventional cytology， the detection rate of malignant hydrothorax and ascites patients is significantly improved. The source of tumor lesions can be determined and the clinical diagnosis rate is increased. It helps clinicians to achieve symptomatic treatment and reduces patient suffering. It is worthy of clinical promotion and application., 百拇医药(范红芸 韩烨 王贝 曾祥胜 李明)
[关键词] 细胞蜡块;恶性胸腹水;细胞学检查
, http://www.100md.com
[中图分类号] R730 [文献标识码] A [文章编号] 1674-0742(2019)07(c)-0034-03
Diagnostic Value of Cell Wax Block for Malignant Hydrothorax and Ascites
FAN Hong-yun， HAN Ye， WANG Bei， ZENG Xiang-sheng， LI Ming
Department of Pathology， Xuyi People's Hospital， Xuyi， Jiangsu Province， 211700 China
[Abstract] Objective To observe the clinical effects of different diagnostic methods for malignant hydrothorax and ascites， and to explore the clinical application characteristics of different diagnostic methods. Methods 79 patients with advanced tumors with malignant hydrothorax and ascites from July 2018 to February 2019 were randomly selected from our hospital. They were randomly divided into control group by 39 patients： routine cytology， observation group 40 cases： the cell wax block examination was performed to observe the detection rate of the two groups of patients and the expression of tumor markers in malignant chest and abdomen. Results The number of cases detected by the cell wax block in the observation group was 30， the detection rate was 75.00%， and the number of cases detected by routine cytology in the control group was 20， the detection rate was 51.28%. The detection rate of the observation group higher than the control group，the difference was statistically significant(χ2=14.442， P<0.05). The background of the observation group was clean after HE staining with cell wax block. At the same time， the tumor cells were abnormally shaped， and they were glandular and papillary; metastatic malignant ascites moc-31 is sensitive and well-defined; in most adenocarcinomas， CEA has a higher expression level and a heavier staining background. Conclusion Compared with conventional cytology， the detection rate of malignant hydrothorax and ascites patients is significantly improved. The source of tumor lesions can be determined and the clinical diagnosis rate is increased. It helps clinicians to achieve symptomatic treatment and reduces patient suffering. It is worthy of clinical promotion and application., 百拇医药(范红芸 韩烨 王贝 曾祥胜 李明)