盐酸左氧氟沙星替代标准三联中的阿莫西林或克拉霉素治疗幽门螺杆菌感染的疗效比较分析(1)
[摘要] 目的 探討盐酸左氧氟沙星替代标准三联中的阿莫西林或克拉霉素治疗幽门螺杆菌感染的疗效。 方法 方便选取2016年9月—2018年9月该院收治的120例幽门螺杆菌感染患者，随机分为对照组、试验1组、试验2组，每组40例，其中予以对照组标准三联方案治疗，予以试验1组奥美拉唑+盐酸左氧氟沙星+克拉霉素治疗，予以试验2组奥美拉唑+盐酸左氧氟沙星+阿莫西林治疗，比较3组幽门螺杆菌根除率。 结果 试验1组幽门螺杆菌根除39例，根除率为97.5%，与试验2组幽门螺杆菌根除38例，根除率为95.0%，两组比较差异无统计学意义(χ2=0.346，P=0.556)，对照组幽门螺杆菌根除28例，根除率为70.0%，试验1组和试验2组幽门螺杆菌根除率均明显高于对照组，3组相比，差异有统计学意义(P<0.05)。 结论 盐酸左氧氟沙星替代标准三联中的阿莫西林或克拉霉素治疗幽门螺杆菌感染能够获得优于标准三联方案的临床疗效。
[关键词] 幽门螺杆菌感染;盐酸左氧氟沙星;标准三联方案;幽门螺杆菌根除率
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[中图分类号] R57 [文献标识码] A [文章编号] 1674-0742(2019)07(c)-0115-03
Comparative Analysis of the Efficacy of Levofloxacin Hydrochloride in Replacing Standard Thyroxine or Clarithromycin in the Treatment of Helicobacter Pylori infection
LIU Yi-xi
Inner District， Tangxia Hospital， Dongguan， Guangdong Province， 523720 China
[Abstract] Objective To investigate the efficacy of levofloxacin hydrochloride in the treatment of Helicobacter pylori infection by amoxicillin or clarithromycin in standard triple. Methods 120 patients with Helicobacter pylori infection admitted to the hospital from September 2016 to September 2018 were randomly divided into the control group， the experimental group 1 and the experimental group 2， 40 patients in each group， including the control group of standard triple therapy. The experimental group 1 of omeprazole + levofloxacin hydrochloride + clarithromycin; experimental group 2 of omeprazole + levofloxacin hydrochloride + amoxicillin. The eradication rates of three groups of Helicobacter pylori were compared. Results In the experimental group 1， 39 cases of Helicobacter pylori eradication were eradicated， the eradication rate was 97.5%， and the eradication rate of Helicobacter pylori eradication was 38 cases. The eradication rate was 95.0%. There was no statistically significant difference between the two groups (χ2=0.346， P=0.556). In the control group， 28 cases of Helicobacter pylori eradication were eradicated， the eradication rate was 70.0%. The eradication rate of Helicobacter pylori in the experimental group 1 and the experimental group 2 was significantly higher than that in the control group. The difference was statistically significant (P<0.05). Conclusion Levofloxacin hydrochloride can replace the standard triplex amoxicillin or clarithromycin in the treatment of Helicobacter pylori infection can achieve better clinical efficacy than the standard triple therapy.
[Key words] Helicobacter pylori infection; Levofloxacin hydrochloride; Standard triple regimen; Helicobacter pylori eradication rate, 百拇医药(刘一曦)
[关键词] 幽门螺杆菌感染;盐酸左氧氟沙星;标准三联方案;幽门螺杆菌根除率
, http://www.100md.com
[中图分类号] R57 [文献标识码] A [文章编号] 1674-0742(2019)07(c)-0115-03
Comparative Analysis of the Efficacy of Levofloxacin Hydrochloride in Replacing Standard Thyroxine or Clarithromycin in the Treatment of Helicobacter Pylori infection
LIU Yi-xi
Inner District， Tangxia Hospital， Dongguan， Guangdong Province， 523720 China
[Abstract] Objective To investigate the efficacy of levofloxacin hydrochloride in the treatment of Helicobacter pylori infection by amoxicillin or clarithromycin in standard triple. Methods 120 patients with Helicobacter pylori infection admitted to the hospital from September 2016 to September 2018 were randomly divided into the control group， the experimental group 1 and the experimental group 2， 40 patients in each group， including the control group of standard triple therapy. The experimental group 1 of omeprazole + levofloxacin hydrochloride + clarithromycin; experimental group 2 of omeprazole + levofloxacin hydrochloride + amoxicillin. The eradication rates of three groups of Helicobacter pylori were compared. Results In the experimental group 1， 39 cases of Helicobacter pylori eradication were eradicated， the eradication rate was 97.5%， and the eradication rate of Helicobacter pylori eradication was 38 cases. The eradication rate was 95.0%. There was no statistically significant difference between the two groups (χ2=0.346， P=0.556). In the control group， 28 cases of Helicobacter pylori eradication were eradicated， the eradication rate was 70.0%. The eradication rate of Helicobacter pylori in the experimental group 1 and the experimental group 2 was significantly higher than that in the control group. The difference was statistically significant (P<0.05). Conclusion Levofloxacin hydrochloride can replace the standard triplex amoxicillin or clarithromycin in the treatment of Helicobacter pylori infection can achieve better clinical efficacy than the standard triple therapy.
[Key words] Helicobacter pylori infection; Levofloxacin hydrochloride; Standard triple regimen; Helicobacter pylori eradication rate, 百拇医药(刘一曦)