喘息性支气管炎患儿应用孟鲁司特钠治疗的临床研究(1)
[摘要] 目的 研究喘息性支氣管炎患儿应用孟鲁司特钠治疗的临床效果。方法 方便选择该院在2017年10月—2018年12月期间收治的喘息性支气管炎患儿168例，将其随机分为对照组(84例)与观察组(84例)，对照组患儿采用常规治疗，观察组患儿在对照组基础上采用孟鲁司特钠治疗，对比分析两组患儿的治疗效果。结果 观察组患儿(96.43%)的治疗优良率显著高于对照组(78.57%)，差异有统计学意义(χ2=14.582，P<0.05);观察组患儿的主要症状消失时间和住院时间均显著短于对照组，差异有统计学意义(t=12.354、6.865、6.477、6.059，P<0.05);观察组患儿的发作期与缓解期LTC4水平均显著低于对照组，差异有统计学意义(t=3.221、6.308，P<0.05);观察组患儿随访1年后的喘息症状发生情况和呼吸道再次感染发生情况均显著低于对照组，差异有统计学意义(χ2=13.173、14.524，P<0.05)。结论在喘息性支气管炎患儿中应用孟鲁司特钠治疗效果显著，可有效缓解患儿的临床症状，加快病情恢复速度，缩短患儿的住院时间，有利于提高患儿的预后效果和生活质量，具有临床应用价值。
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[关键词] 喘息性支气管炎;孟鲁司特钠;发作期;缓解期
[中图分类号] R472 [文献标识码] A [文章编号] 1674-0742(2019)08(a)-0070-03
[Abstract] Objective To study the clinical effect of montelukast sodium on children with asthmatic bronchitis. Methods Convenient a total of 168 children with asthmatic bronchitis admitted to our hospital from October 2017 to December 2018 were selected and randomly divided into the control group (84 cases) and the observation group (84 cases). The control group received the conventional treatment. Based on this， the children in the observation group were treated with montelukast sodium. The therapeutic effects of the two groups were compared and analyzed. Results The excellent and good rate of treatment in the observation group (96.43%) was significantly higher than that in the control group (78.57%)，the difference was statistically significant(χ2=14.582， P<0.05). The disappearance time of main symptoms and hospitalization time，the difference was statistically significant(t=12.354，6865，6.477，6.059， P<0.05) in the observation group were significantly shorter than those in the control group. The level of LTC4 of attack period and remission period in the observation group was significantly lower than that in the control group，the difference was statistically significant(t=3.221，6.308， P<0.05). After one-year following， the incidence of wheezing symptoms and re-infection of respiratory tract in the observation group was significantly lower than that in the control group，the difference was statistically significant(χ2=13.173、14.524， P<0.05). Conclusion The application of montelukast sodium in children with asthmatic bronchitis has remarkable therapeutic effect. It can effectively alleviate the clinical symptoms of children， speed up the recovery of the disease， shorten the hospitalization time of children， and improve the prognosis and quality of life， which has clinical application value., http://www.100md.com(秦立莉)
, http://www.100md.com
[关键词] 喘息性支气管炎;孟鲁司特钠;发作期;缓解期
[中图分类号] R472 [文献标识码] A [文章编号] 1674-0742(2019)08(a)-0070-03
[Abstract] Objective To study the clinical effect of montelukast sodium on children with asthmatic bronchitis. Methods Convenient a total of 168 children with asthmatic bronchitis admitted to our hospital from October 2017 to December 2018 were selected and randomly divided into the control group (84 cases) and the observation group (84 cases). The control group received the conventional treatment. Based on this， the children in the observation group were treated with montelukast sodium. The therapeutic effects of the two groups were compared and analyzed. Results The excellent and good rate of treatment in the observation group (96.43%) was significantly higher than that in the control group (78.57%)，the difference was statistically significant(χ2=14.582， P<0.05). The disappearance time of main symptoms and hospitalization time，the difference was statistically significant(t=12.354，6865，6.477，6.059， P<0.05) in the observation group were significantly shorter than those in the control group. The level of LTC4 of attack period and remission period in the observation group was significantly lower than that in the control group，the difference was statistically significant(t=3.221，6.308， P<0.05). After one-year following， the incidence of wheezing symptoms and re-infection of respiratory tract in the observation group was significantly lower than that in the control group，the difference was statistically significant(χ2=13.173、14.524， P<0.05). Conclusion The application of montelukast sodium in children with asthmatic bronchitis has remarkable therapeutic effect. It can effectively alleviate the clinical symptoms of children， speed up the recovery of the disease， shorten the hospitalization time of children， and improve the prognosis and quality of life， which has clinical application value., http://www.100md.com(秦立莉)