厄贝沙坦联合氨氯地平治疗老年高血压患者的效果评价(1)
[摘要] 目的 评价厄贝沙坦联合氨氯地平治疗老年高血压患者效果。方法 研究对象为方便选取2015年2月—2018年2月老年高血压患者例数200例，采用每日患者挂号的自然序列，单号为观察组，双号为对照组，分别实施厄贝沙坦联合氨氯地平治疗以及常规治疗，将两组患者的血压水平、治疗效果、肾小管功能指标以及尿微量蛋白指标进行对比。结果 治疗后，观察组收缩压(125.52±1.34)mmHg、舒张压(70.64±1.32)mmHg均低于对照组(t=54.458 3、57.286 2，P<0.05);观察组NAG(11.32±1.02)mg/L、Kim-1(469.32±1.54)ng/L，较对照组指标更有优势(t=34.328 8、288.895 5，P<0.05);观察组治疗总有效率95.00%高于对照组74.00%(χ2=16.835 3，P<0.05);治疗后，观察组老年高血压患者mAlb(14.09±5.61)mg/L、RBP(0.21±0.06)mg/L低于对照组(t=7.730 2，16.641 0，P<0.05)。结论 厄贝沙坦联合氨氯地平治疗老年高血压患者的效果十分显著，且安全性较高，对肾脏具有保护作用。
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[关键词] 厄贝沙坦;氨氯地平;老年高血压;效果评价
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2019)09(a)-0097-03
[Abstract] Objective Convenient selected to evaluate the effect of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients. Methods A total of 200 elderly patients with hypertension from February 2015 to February 2018 were enrolled. The natural sequence of daily patient registration was used. The single number was the observation group and the double number was the control group. The irbesartan combined with amlodipine and conventional treatment were performed. Blood pressure levels， treatment effects， renal tubular function indicators， and urine microprotein indicators were compared between the two groups. Results After treatment the systolic blood pressure (125.52±1.34) mmHg and diastolic blood pressure (70.64±1.32) mmHg in the observation group were lower than those in the control group (t=54.458 3， 57.286 2，P<0.05); observation group NAG (11.32±1.02) mg/L， Kim-1 (469.32±1.54) ng/L， which was superior to the control group (t=34.328 8，288.895 5，P<0.05); the total effective rate of the observation group was 95.00% higher than that of the control group 74.00% (χ2=16.835 3，P<0.05); after treatment， mAlb (14.09±5.61) mg/L and RBP (0.21±0.06) mg/L in elderly hypertensive patients in the observation group were lower than the control group(t=7.730 2，16.604 1，P<0.05). Conclusion The efficacy of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients is very significant， and it is safe and has a protective effect on the kidney.
[Key words] Irbesartan; Amlodipine; Elderly hypertension; Effect evaluation
隨着社会人口老年化，老年高血压发病率随年龄增长而增高，老年人易受到器官功能储备能力下降、多病共存、服药种类较多等多种因素的影响，故此，在选择药物方面，应以不良反应小，药物间相互不良反应小的药物、方便、依从性好的药物为主，能够提高治疗安全性，避免不良事件的发生[1-2]。因此，该院将收取时间在2015年2月—2018年2月200例老年高血压患者作为研究对象，分别实施不同治疗，探讨治疗效果，现报道如下。
1 资料与方法, 百拇医药(聂祥碧)
, http://www.100md.com
[关键词] 厄贝沙坦;氨氯地平;老年高血压;效果评价
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2019)09(a)-0097-03
[Abstract] Objective Convenient selected to evaluate the effect of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients. Methods A total of 200 elderly patients with hypertension from February 2015 to February 2018 were enrolled. The natural sequence of daily patient registration was used. The single number was the observation group and the double number was the control group. The irbesartan combined with amlodipine and conventional treatment were performed. Blood pressure levels， treatment effects， renal tubular function indicators， and urine microprotein indicators were compared between the two groups. Results After treatment the systolic blood pressure (125.52±1.34) mmHg and diastolic blood pressure (70.64±1.32) mmHg in the observation group were lower than those in the control group (t=54.458 3， 57.286 2，P<0.05); observation group NAG (11.32±1.02) mg/L， Kim-1 (469.32±1.54) ng/L， which was superior to the control group (t=34.328 8，288.895 5，P<0.05); the total effective rate of the observation group was 95.00% higher than that of the control group 74.00% (χ2=16.835 3，P<0.05); after treatment， mAlb (14.09±5.61) mg/L and RBP (0.21±0.06) mg/L in elderly hypertensive patients in the observation group were lower than the control group(t=7.730 2，16.604 1，P<0.05). Conclusion The efficacy of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients is very significant， and it is safe and has a protective effect on the kidney.
[Key words] Irbesartan; Amlodipine; Elderly hypertension; Effect evaluation
隨着社会人口老年化，老年高血压发病率随年龄增长而增高，老年人易受到器官功能储备能力下降、多病共存、服药种类较多等多种因素的影响，故此，在选择药物方面，应以不良反应小，药物间相互不良反应小的药物、方便、依从性好的药物为主，能够提高治疗安全性，避免不良事件的发生[1-2]。因此，该院将收取时间在2015年2月—2018年2月200例老年高血压患者作为研究对象，分别实施不同治疗，探讨治疗效果，现报道如下。
1 资料与方法, 百拇医药(聂祥碧)