甲钴胺联合盐酸氨基葡萄糖对坐骨神经痛的疗效及安全性分析(1)

http://www.100md.com 2020年3月5日 《中外医疗》 20207

     [摘要] 目的 分析聯合盐酸氨基葡萄糖及甲钴胺在治疗坐骨神经痛中的效果和安全性。 方法 方便选取2016年1月—2019年6月该院接收的坐骨神经痛共60例患者为研究对象，根据数字表法随机分成对照组(按常规开展治疗)与观察组(在对照组基础之上使用盐酸氨基葡萄糖与甲钴胺)，各有30例，统计并比较两组治疗有效率、治疗前后疼痛评分、治疗后的安全指数和不良反应情况。 结果 观察组治疗有效率是93.33%比对照组73.33%更高(χ2=9.279，P=0.002)。治疗前，两组VAS评分差异无统计学意义(t=0.145，P=0.443)。治疗3 d、7 d、14 d时，观察组VAS评分比对照组更低，差异有统计学意义(t=3.140、4.027、5.235，P=0.001、0.000、0.000)。治疗后，观察组的腓肠肌湿质量指数、坐骨神经功能指数以及神经传导速度比对照组更高，后肢拉力差值比对照组更低，差异有统计学意义(t=7.547、12.385、13.152、15.756，P=0.000、0.000、0.000、0.000)。观察不良反应率6.67%与对照组10.00%，差异无统计学意义(χ2=0.726，P=0.394)。结论 联合盐酸氨基葡萄糖及甲钴胺对坐骨神经痛疗效显著，能减轻患者的疼痛程度，具有较高安全性。

    [关键词] 坐骨神经痛;盐酸氨基葡萄糖;甲钴胺;治疗有效率;安全性

    [中图分类号] R745 [文献标识码] A [文章编号] 1674-0742(2020)03(a)-0107-03

    Efficacy and Safety of Mecobalamin Combined with Glucosamine Hydrochloride in Sciatica

    YU Zhi-mou

    Department of Internal Medicine， Luhe County People's Hospital， Shanwei， Guangdong Province， 516600 China

    [Abstract] Objective To analyze the effect and safety of combining glucosamine hydrochloride and mecobalamin in the treatment of sciatica. Methods A total of 60 patients with sciatica received in the hospital from January 2016 to June 2019 were convenient selected as the research subjects. They were randomly divided into a control group (conventional treatment) and an observation group (based on the control group using glucosamine hydrochloride and methylcobalt)， 30 cases each， and the treatment efficiency， pain score before and after treatment， safety index after treatment and adverse reactions were counted and compared between the two groups. Results The effective rate of treatment in observation group was 93.33% higher than 73.33% in control group (χ2=9.279， P=0.002). Before treatment， there was no statistically significant difference in VAS scores between the two groups (t=0.145， P=0.443). At 3 d， 7 d， and 14 d of treatment， the VAS score in the observation group was lower than that in the control group， with significant differences (t=3.140， 4.027， 5.235， P=0.001， 0.000， 0.000). After treatment， the gastrocnemius muscle wet mass index， sciatic nerve function index， and nerve conduction velocity of the observation group were higher than those of the control group， and the difference in hind limb tension was lower than that of the control group， with significant differences (t=7.547， 12.385， 13.152， 15.756， P=0.000， 0.000， 0.000， 0.000). There was no significant difference in the adverse reaction rate between 6.67% and 10.00% in the control group (χ2=0.726， P=0.394). Conclusion The combination of glucosamine hydrochloride and mecobalamin has a significant effect on sciatica， can reduce the pain of patients， has high safety.(余志谋)

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