2型糖尿病及并发症与血糖C肽、糖化血红蛋白相关性的临床研究(1)
[摘要] 目的 探究 2型糖尿病及并發症与血糖C肽、糖化血红蛋白相关性。 方法 以2017年1月—2019年11月为研究时区，方便选取其中该院接受 2型糖尿病治疗的72例患者作为研究对象，依据其临床诊断细分为单纯2型糖尿病组(30例)及2型糖尿病并发症组(42例)，另选择28名健康者作为参照组。采用生化及化学发光免疫方法检测各组对象FBG、2 hBG、FC-P、2 hC-P 以及HbAlc水平。 结果 与参照组FBG(5.47±0.39)mmol/L、2 hPG(9.05±0.57)mmol/L、FC-P(1.07±0.10)μg/L、2 hC-P(2.12±0.28)μg/L、HbAlc(29.51±3.74)%相比，研究对象两组各项指标[单纯组：FBG(8.81±0.63)mmol/L、2 hPG(12.10±0.77)mmol/L、FC-P(1.61±0.15)μg/L、2 hC-P(4.59±0.42)μg/L、HbAlc(9.07±2.07)%;并发症组：FBG(10.21±0.68)mmol/L、2 hPG(13.57±0.82)mmol/L、FC-P(1.28±0.12)μg/L、2 hC-P(3.29±0.38)μg/L、HbAlc(11.83±1.88)%]均差异有统计学意义(单纯组与参照组对比，t=13.254、21.631、19.708、32.078、54.074，P<0.05;并发症组与参照组对比，t=45.143、35.591、11.053、19.831、60.966，P<0.05);而并发症组各指标相较于单纯2型糖尿病组差异有统计学意义(t=13.334、11.575、17.368、22.034、9.517，P<0.05)。此外，分析研究对象两组的各项指标发现，2型糖尿病与HbAlc和FC-P均具较强的相关性，其相关系数分别为0.81和0.83。 结论 血糖C肽及糖化血红蛋白检测项目与 2型糖尿病及其并发症具有较好的相关性，能从一定程度上反映2型糖尿病及其并发症患者的病情。
[关键词] 2型糖尿病;并发症;血糖C肽;糖化血红蛋白;相关性
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2020)08(a)-0043-03
Clinical Study on the Relationship between Type 2 Diabetes and Complications， Blood Glucose C-peptide and Glycated Hemoglobin
ZHANG Jun-jun
Department of Pharmacy， Jiangning Hospital， Nanjing， Jiangsu Province， 211100 China
[Abstract] Objective Explore the relationship between type 2 diabetes and complications and blood glucose C peptide and glycated hemoglobin. Methods From January 2017 to November 2019， 72 patients with type 2 diabetes mellitus in the hospital were conveniently selected as the subjects of study. According to their clinical diagnosis， they were divided into simple type 2 diabetes mellitus group (30 cases) and type 2 diabetes mellitus complicated group (42 cases)， and 28 healthy subjects were selected as the reference group. The levels of FBG， 2hBG， FC-P， 2hC-P and HbAlc were detected by biochemical and chemiluminescence immunoassay. Results With reference group FBG (5.47±0.39) mmol/L， 2 hPG (9.05±0.57) mmol/L， FC-P (1.07±0.10) μg/L， 2 hC-P (2.12±0.28) μg/L， HbAlc (29.51±3.74)% Compared with the indicators of the two groups of the research object [simple group： FBG (8.81±0.63) mmol/L， 2 hPG (12.10±0.77) mmol/L， FC-P (1.61±0.15)μg/L， 2 hC-P (4.59±0.42) μg/L， HbAlc (9.07±2.07)%; Complication group： FBG (10.21±0.68) mmol/L， 2 hPG (13.57±0.82) mmol/L， FC -P (1.28±0.12) μg/L， 2 hC-P (3.29±0.38) μg/L， HbAlc (11.83±1.88)%]， the difference is statistically significant (compared to the simple group and the reference group(t=13.254， 21.631， 19.708， 32.078， 54.074， P<0.05); compared with the reference group in the complication group(t=45.143， 35.591， 11.053， 19.831， 60.966， P<0.05); and each index of the complication group was compared with simple type 2 diabetes.The difference was statistically significant (t=13.334， 11.575， 17.368， 22.034， 9.517， P<0.05). In addition， the analysis of the indicators of the two groups of research subjects found that type 2 diabetes had a strong correlation with HbAlc and FC-P， and the correlation coefficients were 0.81 and 0.83， respectively.Conclusion The detection items of blood glucose C peptide and glycosylated hemoglobin have a good correlation with type 2 diabetes mellitus and its complications， and can reflect the condition of type 2 diabetes mellitus and its complications to a certain extent., 百拇医药(张俊俊)
[关键词] 2型糖尿病;并发症;血糖C肽;糖化血红蛋白;相关性
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2020)08(a)-0043-03
Clinical Study on the Relationship between Type 2 Diabetes and Complications， Blood Glucose C-peptide and Glycated Hemoglobin
ZHANG Jun-jun
Department of Pharmacy， Jiangning Hospital， Nanjing， Jiangsu Province， 211100 China
[Abstract] Objective Explore the relationship between type 2 diabetes and complications and blood glucose C peptide and glycated hemoglobin. Methods From January 2017 to November 2019， 72 patients with type 2 diabetes mellitus in the hospital were conveniently selected as the subjects of study. According to their clinical diagnosis， they were divided into simple type 2 diabetes mellitus group (30 cases) and type 2 diabetes mellitus complicated group (42 cases)， and 28 healthy subjects were selected as the reference group. The levels of FBG， 2hBG， FC-P， 2hC-P and HbAlc were detected by biochemical and chemiluminescence immunoassay. Results With reference group FBG (5.47±0.39) mmol/L， 2 hPG (9.05±0.57) mmol/L， FC-P (1.07±0.10) μg/L， 2 hC-P (2.12±0.28) μg/L， HbAlc (29.51±3.74)% Compared with the indicators of the two groups of the research object [simple group： FBG (8.81±0.63) mmol/L， 2 hPG (12.10±0.77) mmol/L， FC-P (1.61±0.15)μg/L， 2 hC-P (4.59±0.42) μg/L， HbAlc (9.07±2.07)%; Complication group： FBG (10.21±0.68) mmol/L， 2 hPG (13.57±0.82) mmol/L， FC -P (1.28±0.12) μg/L， 2 hC-P (3.29±0.38) μg/L， HbAlc (11.83±1.88)%]， the difference is statistically significant (compared to the simple group and the reference group(t=13.254， 21.631， 19.708， 32.078， 54.074， P<0.05); compared with the reference group in the complication group(t=45.143， 35.591， 11.053， 19.831， 60.966， P<0.05); and each index of the complication group was compared with simple type 2 diabetes.The difference was statistically significant (t=13.334， 11.575， 17.368， 22.034， 9.517， P<0.05). In addition， the analysis of the indicators of the two groups of research subjects found that type 2 diabetes had a strong correlation with HbAlc and FC-P， and the correlation coefficients were 0.81 and 0.83， respectively.Conclusion The detection items of blood glucose C peptide and glycosylated hemoglobin have a good correlation with type 2 diabetes mellitus and its complications， and can reflect the condition of type 2 diabetes mellitus and its complications to a certain extent., 百拇医药(张俊俊)