中药内服配合保留灌肠治疗慢性溃疡性结肠炎
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2010年7月5日
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[摘要] 目的:探讨中药内服配合保留灌肠治疗慢性溃疡性结肠炎的疗效。方法:将本院收治的慢性溃疡性结肠炎患者64例随机分为观察组和对照组各32例,对照组给予柳氮磺胺吡啶治疗,观察组采用中药内服配合保留灌肠治疗。结果:观察组的总有效率为96.9%,对照组为81.3%,两组比较差异有统计学意义(P<0.05);观察组不良反应发生率为6.3%,对照组为3.1%,两组比较,差异无统计学意义(P>0.05)。结论:中药内服配合保留灌肠治疗慢性溃疡性结肠炎疗效较佳,且不良反应少,值得推广应用。
[关键词] 慢性溃疡性结肠炎;中药;保留灌肠;柳氮磺胺吡啶
[中图分类号] R574.6 [文献标识码]B [文章编号]1674-4721(2010)07(a)-118-02
Oral taken and retention enema with Traditional Chinese Medicine in the treatment of chronic ulcerative colitis
ZHAO Xin1, LIU Ling2
(1. Department of Chinese Medicine, the Hepingli Hospital of Beijing City, Beijing 100013,China;2.Chinese Medicine Hospital of Chang'an area of Xi'an City,Shaanxi Province, Xi'an710100,China)
[Abstract] Objective: To explore the curative effect of oral taken and retention enema with Traditional Chinese Medicine in the treatment of chronic ulcerative colitis. Methods: In our hospital, 64 patients of chronic ulcerative colitis were randomly divided into observation groupand control group, each of 32 cases, the control group was treated by sulfasalazine, the observation group was treated by oral taken and retention enema with Traditional Chinese Medicine. Results: The total effective rate of observation group was 96.9% and 81.3% of the control group, the difference between the two groups was statistically significant (P<0.05);the incidence of adverse reactions of observation group was 6.3% and 3.1% of the control group, the difference was not statistically significance (P>0.05). Conclusion: Oral taken and retention enema with Traditional Chinese Medicine in the treatment of chronic ulcerative colitis has better efficacy and less adverse reaction, it is worth spreading.
[Key words] Chronic ulcerative colitis; Traditional Chinese Medicine; Retention enema; Sulfasalazine
慢性溃疡性结肠炎是一种原因不明的直肠、结肠炎症性疾病,其病变位于大肠,呈连续性弥漫性分布,多数在直肠乙状结肠,可扩展至降结肠、横结肠,也可累及全结肠,一般发病应该积极治疗。笔者采用中药内服配合保留灌肠治疗慢性溃疡性结肠炎效果满意,现分析报道如下:
1 资料与方法
1.1 一般资料
选择本院2009年1～12月收治的慢性溃疡性结肠炎患者64例,均符合第6版《内科学》中该疾病的诊断标准[1]。其中,男34例,女30例;年龄21～65岁,平均(32.6±2.9)岁。病程4个月～6年,平均(10.8±0.7)个月;病变累及直肠19例,直肠乙状结肠31例,左半结肠8例,右半结肠6例。所有患者均以腹泻、腹痛、脓血黏液便为主要临床症状。两组患者的性别、年龄、病程、临床症状等比较,差异无统计学意义(P>0.05),具有可比性。
1.2 方法
本研究中对照组采用柳氮磺胺吡啶片治疗,口服,1 g/次,4次/d,疗程为8周。观察组采用中药内服配合保留灌肠治疗:苦参30 g,黄柏30 g,血竭20 g,白芨30 g,三七粉15 g,白头翁30 g,地榆30 g水煎取浓汁450 ml,早晚餐后各服150 ml,余150 ml保留灌肠治疗。2周为1个疗程,1个疗程结束后,休息5～7 d进行下1个疗程,连用3个疗程。
1.3 疗效判定标准
患者的临床症状消失,结肠镜(或X线)等各项检查肠黏膜正常,大便常规检查无红、白细胞视为治愈。患者临床症状基本消失,结肠镜检查肠黏膜轻度炎症,大便常规检查有少量红、白细胞视为好转。患者临床症状及结肠镜等检查无改善视为无效。治愈+好转=总有效。
1.4 统计学处理
采用SPSS 11.0软件包分析数据,计数资料用χ2检验,P<0.05为差异有统计学意义。
2 结果 ......
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