大剂量谷维素联合β-受体阻滞剂治疗心血管神经症的疗效分析(1)
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[摘要] 目的：探讨大剂量谷维素联合β-受体阻滞剂治疗心血管神经症的疗效。方法：对在本院就诊的74例心血管神经症的患者进行不同治疗方法的分组对照研究。观察组给予大剂量谷维素联合β-受体阻滞剂治疗；对照组常规治疗，2周后对患者进行随访，调查疗效。结果：观察组和对照组各周HAMD评分、HAMA与心血管神经症评分较治疗前均有显著下降。治疗各周后两组HAMD评分与HAMA差异有统计学意义(t1=2.343，2.252；t2=2.317，2.306；t4=2.298，2.318；t6=2.250，2.431)，P<0.05。观察组在治疗后第1、2、4、6周的减分率分别为53.63%、66.44%、79.58%和83.74%。而对照组治疗1、2、4周后减分率无明显变化，两组差异有统计学意义(χ2>3.834)。结论：大剂量谷维素联合β-受体阻滞剂治疗心血管神经症疗效确切，值得临床推广应用。
[关键词] 大剂量谷维素；β-受体阻滞剂；心血管神经症；疗效分析
[中图分类号] R972 [文献标识码]A[文章编号]1674-4721(2011)04(c)-042-02
Efficacy of cardiovascular neuroses treated with high-dose oryzanol combined β-blockers
WANG Zhiyong
People's Hospital of Xinhua County, Hunan Province, Xinhua 417600, China
[Abstract] Objective: To evaluate high-dose oryzanol combined with β-blockers treatment of cardiovascular neurosis patients. Methods: 74 patients with cardiovascular neurosis in our hospital treated with different methods, observation group treated with high dose oryzanol combined β-blockers, control group with conventional treatment, patients were followed up after two weeks. Results: The observation group and control group weekly HAMD score, HAMA scores and cardiovascular neurosis than before treatment were significantly lower. Two weeks after the treatment of the HAMD score and HAMA were significantly different, (t1=2.343,2.252; t2=2.317,2.306; t4=2.298,2.318; t6=2.250,2.431, P<0.05). The observation group 1,2,4,6 weeks after treatment, reduction rate was 53.63%, 66.44%, 79.58% and 83.74%. The control group 1,2,4 weeks after treatment no significant changes in reduction rate, the difference of two groups were significantly(χ2>3.834). Conclusion: High-dose oryzanol combined β-blockers treatment of cardiovascular neurosis iseffective, and it is worthy of clinical application.
[Key words] High-dose oryzanol; β-blockers; Cardiovascular neuroses; Efficacy analysis
心血管神经症(cardiovascularneurosis)是功能性神经症的一种类型，以心血管疾病的有关症状为主要表现。中青年患者较为多见，女性多于男性，尤其是更年期的女性[1]。谷维素是改善自主神经功能和内分泌调节的常用药，β-受体阻滞剂对肾上腺素能受体有抑制作用，能通过减慢心率、减弱心肌收缩力、降低血压、减少心肌耗氧量，缓解儿茶酚胺对心脏的损害，从而改善血管功能[2]。为探讨大剂量谷维素联合β-受体阻滞剂治疗心血管神经症的疗效，笔者对74例患者进行了分组对照分析，现报道如下：
1 资料与方法
1.1 一般资料
选取本院2009年1月～2010年1月门诊诊断为心血管神经症的74例患者为研究对象。随机分为观察组(37例)，男8例，女29例，年龄23～55岁，平均(39.5±14.2)岁；对照组(37例)，男10例，女27例，年龄22～53岁，平均(37.5±16.1)岁。所有患者均符合心血管神经症的诊断标准 ......
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