骨关节炎患者关节软骨TIMP—3启动子区甲基化水平的初步研究(3)

http://www.100md.com 2014年1月15日 彭红春 谢明 沈奕 彭丹

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    参见附件。

     [3] Kashiwagi M，Tortorella M，Nagase H，et al.TIMP-3 is a potent inhibitor of aggrecanase 1(ADAM-TS4)and aggrecanase 2(ADAM-TS5)[J].J Biol Chem，2001，276(16)：12501-12504.

    [4] Smookler DS，Mohammed FF，Kassiri Z，et al.Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation[J].J Immunol，2006，176(2)：721-725.

    [5] Mahmoodi M，Sahebjam S，Smookler D，et al.Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis[J]. Am J Pathol，2005，166(6)：1733-1740.

    [6] Arden N，Nevitt MC.Osteoarthritis：epidemiology[J].Best Pract Res Clin Rheumatol，2006，20(1)：3-25.

    [7] Hashimoto G，Aoki T，Nakamura H，et al.Inhibition of ADAMTS4(aggrecanase-1)by tissue inhibitors of metalloproteinases(TIMP-1，2，3 and 4)[J].FEBS letters，2001， 494(3)：192-195.

    [8] Kevorkian L，Young DA，Darrah C，et al. Expression profiling of metalloproteinases and their inhibitors in cartilage[J].Arthritis Rheum，2004，50(1)：131-141.

    [9] Zeng Y，Rosborough RC，Li Y，et al.Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene [J].Dev Dyn，1998，211(3)：228-237.

    [10] Zreiqat H，Belluoccio D，Smith MM，et al.S100A8 and S100A9 in experimental osteoarthritis[J].Arthritis Res Ther，2010，12(1)：R16.

    [11] Huang Z，Wen Y，Shandilya R，et al.High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer[J].Nucleic Acids Res，2006，34(2)：555-563.

    [12] Kang GH，Lee HJ，Hwang KS，et al.Aberrant CpG island hypermethylation of chronic gastritis，in relation to aging，gender，intestinal metaplasia，and chronic inflammation[J]. Am J Pathol，2003，163(4)：1551-1556.

    (收稿日期：2013-08-02 本文编辑：魏玉坡)

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