光动力疗法联合支架置入治疗食管癌所致气道狭窄的效果观察(3)
本研究结果显示,PDT联合支架置入治疗组患者平均稳定期、平均生存期明显延长(P<0.05),虽然急性黏膜水肿、支气管阻塞发生率较高(P<0.05),但处理后预后较好,支气管再狭窄发生率明显降低(P<0.05)。尽管光敏剂费用相对较高,与其他治疗方法比较操作复杂[14-15],但其在食管癌引起气道狭窄中具有明显有效性和优势。随着没有光过敏和疗效更好的第二代光敏剂出现,PDT在姑息治疗肿瘤中的实用价值得到提高,越来越多的患者会从中获益。
[参考文献]
[1] Simone CB,Friedberg JS,Glatstein E,et al.Photodynamic therapy for the treatment of non-small cell lung cancer[J].J Thorac Dis,2012,4(1):63-75.
[2] Celiko■lu SI,Karayel T,Demirci S,et al.Direct injection of anti-cancer drugs into endobronchial tumours for palliation of major airway obstruction[J].Postgrad Med J,1997, 73(857):159-162.
[3] Freitag L,Ernst A,Unger M,et al.A proposed classification system of central airway stenosis[J].Eur Respir,2007,30(1):7-12.
[4] Chen M,Pennathur A,Luketich JD.Role of photodynamic therapy in unresectable esophageal and lung cancer[J].Lasers Surg Med,2006,38(5):396-402.
[5] Lund ME,Garland R,Ernst A.Airway stenting:applications and practice management considerations[J].Chest,2007, 131(2):579-587.
[6] 牛立志,周红桃,曹斌.光动力疗法联合支架置入姑息性治疗癌性腔道梗阻——附26例报告[J].中国激光医学杂志,2009,18(2):88-91.
[7] Ross P Jr.Photodynamic therapy for airway malignancies:the Ohio State University experience since 1998[J].J Natl Compr Canc Netw,2012,10(Suppl 2):S9-S13.
[8] Jones BU,Helmy M,Brenner M,et al.Photodynamic therapy for patients with advanced non-small-cell carcinoma of the lung[J].Clin Lung Cancer,2001,3(1):37-41.
[9] Lam S,Muller NL,Miller RR,et al.Predicting the response of obstructive endobronchial tumors to photodynamic therapy[J].Cancer,1986,58(10):2298-2306.
[10] Moghissi K.Role of bronchoscopic photodynamic therapy in lung cancer management[J].Curr Opin Pulm Med,2004, 10(4):256-260.
[11] Diaz-Jimenez JP,Martinez-Ballarin JE,Llunell A,et al.Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction[J].Eur Respir J,1999,14(4):800-805.
[12] Chang YC,Lee JM,Ko WJ,et al.Airway obstruction following bronchoscopic photodynamic therapy in early centrally located lung cancer requiring extracorporeal membrane oxygenation[J].J Formos Med Assoc,2013,112(1):54-56.
[13] Radu A,Zellweger M,Grosjean P,et al.Pulse oximeter as a cause of skin burn during photodynamic therapy[J].Endoscopy,1999,31(9):831-833.
[14] Dougherty TJ.An update on photodynamic therapy applications[J].J Clin Laser Med Surg,2002,20(1):3-7.
[15] Langendijk H,de Jong J,Tjwa M,et al.External irradiation versus external irradiation plus endobronchial brac-hytherapy in inoperable non-small cell lung cancer:a prospective randomized study[J].Radiother Oncol,2001, 58(3):257-268.
(收稿日期:2015-02-15 本文编辑:许俊琴) (孔国平 孙健)
[参考文献]
[1] Simone CB,Friedberg JS,Glatstein E,et al.Photodynamic therapy for the treatment of non-small cell lung cancer[J].J Thorac Dis,2012,4(1):63-75.
[2] Celiko■lu SI,Karayel T,Demirci S,et al.Direct injection of anti-cancer drugs into endobronchial tumours for palliation of major airway obstruction[J].Postgrad Med J,1997, 73(857):159-162.
[3] Freitag L,Ernst A,Unger M,et al.A proposed classification system of central airway stenosis[J].Eur Respir,2007,30(1):7-12.
[4] Chen M,Pennathur A,Luketich JD.Role of photodynamic therapy in unresectable esophageal and lung cancer[J].Lasers Surg Med,2006,38(5):396-402.
[5] Lund ME,Garland R,Ernst A.Airway stenting:applications and practice management considerations[J].Chest,2007, 131(2):579-587.
[6] 牛立志,周红桃,曹斌.光动力疗法联合支架置入姑息性治疗癌性腔道梗阻——附26例报告[J].中国激光医学杂志,2009,18(2):88-91.
[7] Ross P Jr.Photodynamic therapy for airway malignancies:the Ohio State University experience since 1998[J].J Natl Compr Canc Netw,2012,10(Suppl 2):S9-S13.
[8] Jones BU,Helmy M,Brenner M,et al.Photodynamic therapy for patients with advanced non-small-cell carcinoma of the lung[J].Clin Lung Cancer,2001,3(1):37-41.
[9] Lam S,Muller NL,Miller RR,et al.Predicting the response of obstructive endobronchial tumors to photodynamic therapy[J].Cancer,1986,58(10):2298-2306.
[10] Moghissi K.Role of bronchoscopic photodynamic therapy in lung cancer management[J].Curr Opin Pulm Med,2004, 10(4):256-260.
[11] Diaz-Jimenez JP,Martinez-Ballarin JE,Llunell A,et al.Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction[J].Eur Respir J,1999,14(4):800-805.
[12] Chang YC,Lee JM,Ko WJ,et al.Airway obstruction following bronchoscopic photodynamic therapy in early centrally located lung cancer requiring extracorporeal membrane oxygenation[J].J Formos Med Assoc,2013,112(1):54-56.
[13] Radu A,Zellweger M,Grosjean P,et al.Pulse oximeter as a cause of skin burn during photodynamic therapy[J].Endoscopy,1999,31(9):831-833.
[14] Dougherty TJ.An update on photodynamic therapy applications[J].J Clin Laser Med Surg,2002,20(1):3-7.
[15] Langendijk H,de Jong J,Tjwa M,et al.External irradiation versus external irradiation plus endobronchial brac-hytherapy in inoperable non-small cell lung cancer:a prospective randomized study[J].Radiother Oncol,2001, 58(3):257-268.
(收稿日期:2015-02-15 本文编辑:许俊琴) (孔国平 孙健)