血清肿瘤标志物检测在盆腔良恶性妇科肿瘤诊断与鉴别诊断中的意义(1)
[摘要]目的 探讨盆腔良恶性妇科肿瘤采取血清肿瘤标志物检测的诊断及鉴别意义。方法 选择2016年7月5日～12月23日在我院收治的盆腔妇科肿瘤患者50例作为研究对象，根据肿瘤性质分为良性组及恶性组(各25例)，另取同期50例健康体检者为对照组。所有患者均予以血清肿瘤标志物检测，观察检测阳性情况及生化指标含量。结果 恶性肿瘤组CA153、CA125陽性率分别为52.00%、92.00%，高于良性肿瘤组(4.00%、60.00%)，差异有统计学意义(P<0.05)，两组CEA、AFP、CA199阳性率比较，差异无统计学意义(P>0.05)；三组CEA、AFP检测阳性率比较，差异无统计学意义(P>0.05)，恶性肿瘤组CA199、CA153、CA125分别为(150.89±7.06)、(107.57±4.24)、(446.19±10.07)U/ml，良性肿瘤组分别为(44.31±3.82)、(17.15±1.38)、(52.43±5.65)U/ml，均高于对照组 [(12.19±0.93)、(8.02±0.46)、(15.02±2.18)U/ml]，差异均有统计学意义(P<0.05)。结论 血清肿瘤标志物检测应用于盆腔良恶性妇科肿瘤诊断中，临床价值较高，利于治疗方案的制定。
[关键词]盆腔良恶性妇科肿瘤；诊断；血清肿瘤标志物检测
[中图分类号] R473 [文献标识码] A [文章编号] 1674-4721(2017)12(c)-0123-03
[Abstract]Objective To investigate the diagnosis and differential significance of serum tumor markers in pelvic benign and malignant gynecological tumors.Methods Fifty patients with pelvic gynecologic tumor in our hospital from July 5 to December 23，2016 were selected as the research object，According to the nature of the tumor was divided into benign and malignant group(25 cases)，and 50 healthy subjects were taken as control group.All patients were given serum tumor markers to detect the detection of positive and biochemical indicators.Results The positive rate of CA153，CA125 of malignant group were 52.00%，92.00%，higher than the benign group(4.00%，60.00%)，the difference was statistically significant(P<0.05)，The positive rate of CEA，AFP，CA199 in the two groups had，no significant difference(P>0.05)；CEA，AFP of the three groups had no statistical significance(P>0.05).In the malignant groups，CA199，CA153，CA125，respectively were[(150.89±7.06)，(107.57±4.24)，(446.19±10.07)U/ml]，benign tumor group [(44.31±3.82)，(17.15±1.38)，(52.43±5.65)U/ml]，were higher than[12.19±0.93)，(8.02±0.46)，(15.02±2.18)U/ml] of the control group，was statistically significant(P<0.05).Conclusion The detection of serum tumor markers in the diagnosis of pelvic benign and malignant gynecological tumors has a high clinical value and is favorable to the development of treatment regimens.
[Key words]Pelvic benign and malignant gynecological tumors；Diagnosis；Serum tumor markers detection
妇科肿瘤严重危害着女性身心健康，作为常见疾病，可分为良性及恶性，良性肿瘤予以相应治疗即可痊愈[1-3]，但治疗不及时或不当，极有可能发展为恶性疾病，故确切可靠的诊断方法极为重要，早期鉴别良恶性肿瘤对于疾病发生发展意义重大。血清标志物检测能够直接反映肿瘤生长情况，临床应用较为广泛。本文旨在探讨血清肿瘤标志物检测应用于盆腔良恶性妇科肿瘤鉴别中的临床意义。
1 资料与方法
1.1 一般资料
选择2016年7月5日～12月23日在我院收治的盆腔妇科肿瘤患者50例作为研究对象，均经病理学、影像学等检查确诊，根据肿瘤性质分为良性组及恶性组(各25例)，另取同期50例健康体检者为对照组(无妇科疾病史)，所有研究对象均获知情权，此次研究经医学伦理委员会批准。恶性肿瘤组25例，年龄35～59岁，平均(40.49±3.85)岁；体重(50.48±2.73)kg。良性肿瘤组25例，年龄37～60岁，平均(40.70±3.69)岁；体重(50.21±2.54)kg。对照组50例，年龄36～58岁，平均(40.61±3.55)岁；体重(50.03±2.98)kg。三组患者的一般资料差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(吴杰儒)
[关键词]盆腔良恶性妇科肿瘤；诊断；血清肿瘤标志物检测
[中图分类号] R473 [文献标识码] A [文章编号] 1674-4721(2017)12(c)-0123-03
[Abstract]Objective To investigate the diagnosis and differential significance of serum tumor markers in pelvic benign and malignant gynecological tumors.Methods Fifty patients with pelvic gynecologic tumor in our hospital from July 5 to December 23，2016 were selected as the research object，According to the nature of the tumor was divided into benign and malignant group(25 cases)，and 50 healthy subjects were taken as control group.All patients were given serum tumor markers to detect the detection of positive and biochemical indicators.Results The positive rate of CA153，CA125 of malignant group were 52.00%，92.00%，higher than the benign group(4.00%，60.00%)，the difference was statistically significant(P<0.05)，The positive rate of CEA，AFP，CA199 in the two groups had，no significant difference(P>0.05)；CEA，AFP of the three groups had no statistical significance(P>0.05).In the malignant groups，CA199，CA153，CA125，respectively were[(150.89±7.06)，(107.57±4.24)，(446.19±10.07)U/ml]，benign tumor group [(44.31±3.82)，(17.15±1.38)，(52.43±5.65)U/ml]，were higher than[12.19±0.93)，(8.02±0.46)，(15.02±2.18)U/ml] of the control group，was statistically significant(P<0.05).Conclusion The detection of serum tumor markers in the diagnosis of pelvic benign and malignant gynecological tumors has a high clinical value and is favorable to the development of treatment regimens.
[Key words]Pelvic benign and malignant gynecological tumors；Diagnosis；Serum tumor markers detection
妇科肿瘤严重危害着女性身心健康，作为常见疾病，可分为良性及恶性，良性肿瘤予以相应治疗即可痊愈[1-3]，但治疗不及时或不当，极有可能发展为恶性疾病，故确切可靠的诊断方法极为重要，早期鉴别良恶性肿瘤对于疾病发生发展意义重大。血清标志物检测能够直接反映肿瘤生长情况，临床应用较为广泛。本文旨在探讨血清肿瘤标志物检测应用于盆腔良恶性妇科肿瘤鉴别中的临床意义。
1 资料与方法
1.1 一般资料
选择2016年7月5日～12月23日在我院收治的盆腔妇科肿瘤患者50例作为研究对象，均经病理学、影像学等检查确诊，根据肿瘤性质分为良性组及恶性组(各25例)，另取同期50例健康体检者为对照组(无妇科疾病史)，所有研究对象均获知情权，此次研究经医学伦理委员会批准。恶性肿瘤组25例，年龄35～59岁，平均(40.49±3.85)岁；体重(50.48±2.73)kg。良性肿瘤组25例，年龄37～60岁，平均(40.70±3.69)岁；体重(50.21±2.54)kg。对照组50例，年龄36～58岁，平均(40.61±3.55)岁；体重(50.03±2.98)kg。三组患者的一般资料差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(吴杰儒)