肺表面活性物质联合高频震荡通气与米力农治疗新生儿持续性肺动脉高压的临床效果(1)
[摘要]目的 观察分析肺表面活性物质联合高频震荡通气与米力农治疗新生儿持续性肺动脉高压(PPHN)的临床效果。方法 将我院2015年3月～2016年8月收治的114例PPHN患者作为实验对象，随机分成对照组1、对照组2及观察组，每组各38例。对照组1使用高頻震荡通气，对照组2使用高频震荡通气与米力农治疗，观察组使用高频震荡通气联合肺表面活性物质与米力农治疗，比较分析三组患儿治疗效果、肺动脉收缩压(PASP)及機械通气时间等。结果 对照组1治疗总有效率为26.31%(10/38)，对照组2治疗总有效率为47.37%(18/38)，观察组为92.11%(35/38)，观察组治疗总有效率显著高于对照组1与对照组2；观察组治疗后的PASP、吸氧浓度、动脉二氧化碳分压(PaCO2)明显低于对照组(P<0.05)，而相较于对照组1与对照组2，观察组动脉氧分压(PaO2)明显较高，差异有统计学意义(P<0.05)；观察组总机械通气时间为(83.46±9.91) h，明显短于对照组2的(118.35±12.57) h、对照组1的(136.35±11.23) h，差异有统计学意义(P<0.05)。结论 高频震荡通气联合肺表面活性物质与米力农治疗PPHN的临床效果较好，有效提升了治疗总有效率，改善PASP及机械通气时间，值得使用与推广。
[关键词]高频震荡通气；肺表面活性物质；米力农；持续性肺动脉高压
[中图分类号] R722.19 [文献标识码] A [文章编号] 1674-4721(2018)3(a)-0112-03
Clinical effect of pulmonary surfactant combined with high-frequency oscillatory ventilation and Milrinone in the treatment of persistent pulmonary hypertension of newborn
WEI Cheng-sheng LIAO Qiu-xian
Department of Paediatrics，Maternal and Child Health Care Hospital of Wuhua County，Guangdong Province，Wuhua 514400，China
[Abstract]Objective To observe the clinical effect of pulmonary surfactant combined with high-frequency oscillatory ventilation and Milrinone in the treatment of persistent pulmonary hypertension of newborn (PPHN).Methods From March 2015 to August 2016，114 PPHN cases treated in our hospital were enrolled as research objects and evenly divided into control group 1，control group 2，and observation group in random，38 cases in each group.Only high frequency oscillatory ventilation was used in the control group 1，and combination of high frequency oscillatory ventilation and Milrinone was applied in the control group 2，while in the observation group，high frequency oscillatory ventilation combined with pulmonary surfactant and Milrinone was adopted.The therapeutic effect，pulmonary artery systolic pressure (PASP) and mechanical ventilation time among three groups were comparatively analyzed.Results The total therapeutic effectiveness rate was 26.31%(10/38) in the control group 1，47.37%(18/38) in the control group 2，and 92.11%(35/38) in the observation group.Obviously，the total therapeutic effectiveness rate in the observation group was higher than that in the other two groups.The indexes of PASP，oxygen-intake concentration，and arterial partial pressure of carbon dioxide (PaCO2) in the observation group were much lower than those in the control groups 1 and 2 (P<0.05).Meanwhile，compared with the control groups 1 and 2，arterial oxygen pressure (PaO2) was higher，with statistical significance (P<0.05).The total mechanical ventilation time was (83.46±9.91) h in the observation group，much shorter compared with the control groups 1 and 2，[(136.35±11.23) h and (118.35±12.57) h] respectively，which was displayed a statistical difference (P<0.05).Conclusion Combination of high-frequency oscillatory ventilation，pulmonary surfactant，and Milrinone on treating PPHN obtains a great effect by improving the total effectiveness rate and PASP and shortening the mechanical ventilation，which is worthy of application and promotion.(魏成胜 廖秋娴)