米索前列醇不同给药途径在终止13～20周妊娠中的效果分析(1)
[摘要]目的 探討米索前列醇不同给药途径用于终止13～20周妊娠的效果比较。方法 选取我院2014年6月～2015年6月就诊孕13～20周要求终止妊娠的252例患者，随机分为口服组、舌下含服组和阴道给药组，每组各84例，三组均于第1天和第2天早晚各口服米非司酮75 mg，第3天早上给予米索前列醇600 μg，三组给药方式分别为空腹顿服、阴道放置和舌下含服，比较三组的流产效果、不良反应及可接受性。结果 三组给予米索前列醇后出现腹痛的时间和阴道出血量比较，差异均无统计学意义(P>0.05)；舌下含服组和阴道给药组的完全流产率和24 h流产成功率均高于口服组，差异有统计学意义(P<0.05)。口服组流产成功者所需的引产时间长于舌下含服组和阴道给药组，差异有统计学意义(P<0.05)。三组发热及其他不适(如寒战、头晕、发痒等)的发生率比较，差异无统计学意义(P>0.05)。口服和舌下含服较阴道给药更易被患者接受，差异有统计学意义(P<0.05)。结论 米非司酮配伍舌下含服或阴道给予米索前列醇用于终止中期妊娠具有完全流产率高，引产时间短，24 h流产成功率高，胃肠反应少等优点，更易被患者所接受。
[关键词]米索前列醇；米非司酮；人工流产；投药途径
[中图分类号] R719.3 [文献标识码] A [文章编号] 1674-4721(2018)8(b)-0118-03
Effect analysis of different ways of administration of Misoprostol on termination of gestation for 13 to 20 weeks
HOU Feng ZHOU Ping XING Jia-ling
Department of Gynecology and Obstetrics， Maternal and Child Health Care Hospital of Guangdong Province， Guangzhou 510400， China
[Abstract] Objective To determine effect of different ways of administration of Misoprostol on the termination of the mid-trimester pregnancy (13-20 weeks). Methods A total of 252 cases of receiving termination of the mid-trimester pregnancy in our hospital from June 2014 to June 2015 were selected. They were randomly divided into oral administration group(OA group)， sublingual administration group(SA group)， and vaginal administration group(VA group)， 84 cases in each group. Three groups were given Mifepristone 75 mg every time in the morning and night in the first day and the second day， Misoprostol 600 μg in the third day morning respectively. The abortion effects， adverse reactions and acceptability between the three groups were analyzed. Results There was no statistical difference in the beginning time of the abdominal pain and number hemorrhage among three groups (P>0.05). The complete abortion rate and success rates of abortion in 24 h of the VA group and SA group were statistically significant higher than OA group. The abortion time of OA group were significantly longer than that in the VA group and SA group. No statistically significant differences in the incidence of the side-effect including fever， headache and so on (P>0.05). Oral administration and sublingual administration were more acceptable than that in the VA group， the difference was statistically significant (P<0.05). Conclusion The vaginal administration and sublingual administration of Misoprostol on the termination of the mid-trimester pregnancy have many advantages： high complete abortion rate， short abortion time， high success rates of abortion in 24 h， fewer side-effects. And sublingual administration were more acceptable by patients., http://www.100md.com(侯峰 周平 邢佳玲)
[关键词]米索前列醇；米非司酮；人工流产；投药途径
[中图分类号] R719.3 [文献标识码] A [文章编号] 1674-4721(2018)8(b)-0118-03
Effect analysis of different ways of administration of Misoprostol on termination of gestation for 13 to 20 weeks
HOU Feng ZHOU Ping XING Jia-ling
Department of Gynecology and Obstetrics， Maternal and Child Health Care Hospital of Guangdong Province， Guangzhou 510400， China
[Abstract] Objective To determine effect of different ways of administration of Misoprostol on the termination of the mid-trimester pregnancy (13-20 weeks). Methods A total of 252 cases of receiving termination of the mid-trimester pregnancy in our hospital from June 2014 to June 2015 were selected. They were randomly divided into oral administration group(OA group)， sublingual administration group(SA group)， and vaginal administration group(VA group)， 84 cases in each group. Three groups were given Mifepristone 75 mg every time in the morning and night in the first day and the second day， Misoprostol 600 μg in the third day morning respectively. The abortion effects， adverse reactions and acceptability between the three groups were analyzed. Results There was no statistical difference in the beginning time of the abdominal pain and number hemorrhage among three groups (P>0.05). The complete abortion rate and success rates of abortion in 24 h of the VA group and SA group were statistically significant higher than OA group. The abortion time of OA group were significantly longer than that in the VA group and SA group. No statistically significant differences in the incidence of the side-effect including fever， headache and so on (P>0.05). Oral administration and sublingual administration were more acceptable than that in the VA group， the difference was statistically significant (P<0.05). Conclusion The vaginal administration and sublingual administration of Misoprostol on the termination of the mid-trimester pregnancy have many advantages： high complete abortion rate， short abortion time， high success rates of abortion in 24 h， fewer side-effects. And sublingual administration were more acceptable by patients., http://www.100md.com(侯峰 周平 邢佳玲)