不同疗程肺炎支原体清除治疗对免疫性血小板减少性紫癜患儿的影响(1)
[摘要]目的 比較不同疗程的肺炎支原体(MP)清除治疗对免疫性血小板减少性紫癜(ITP)患儿的影响。方法 选取2017年1月～2018年1月我院收治的58例血清MP-IgM抗体阳性的ITP患儿，采用随机数字表法将其分为实验组与参照组，每组各29例。参照组患儿在常规ITP治疗的基础上给予1个疗程的MP清除治疗;实验组患儿则在常规ITP治疗的基础上给予2～3个疗程的MP清除治疗。比较两组ITP患儿的临床疗效、复发率及转为难治性或慢性ITP的概率。结果 实验组患儿的治疗总有效率(86.21%)与参照组(82.76%)比较，差异无统计学意义(P>0.05);实验组患儿在治疗后6个月、1年内的复发率分别为为3.45%、13.79%，低于参照组的20.69%、37.93%，差异有统计学意义(P<0.05);实验组患儿转为难治性或慢性ITP的概率为3.45%，低于参照组的17.24%，差异有统计学意义(P<0.05)。结论 不同疗程MP清除治疗对ITP患儿的近期疗效无明显影响，但2～3个疗程的治疗能降低ITP的复发率和转为难治性或慢性ITP的概率，有效地改善患儿预后。
[关键词]免疫性性血小板减少性紫癜;肺炎支原体感染;不同疗程;复发率
[中图分类号] R554.6 [文献标识码] A [文章编号] 1674-4721(2019)9(a)-0118-03
Effect of different courses of Mycoplasma Pneumoniae clearance on immune thrombocytopenic purpura in children
ZHANG Xiao-wen ZHOU Fan FAN Xiao-yan
Department of Infant Medicine， Jiujiang Maternal and Child Health Hospital， Jiangxi Province， Jiujiang 332000， China
[Abstract] Objective To compare the effect of different courses of Mycoplasma Pneumoniae (MP) clearance on immune thrombocytopenic purpura (ITP) in children. Methods From January 2017 to January 2018， 58 ITP children with positive serum MP-IgM antibody were selected. They were divided into experimental group and reference group by random number table method， with 29 cases in each group. The control group was given one course of MP clearance therapy on the basis of routine ITP therapy， while the experimental group was given 2 to 3 courses of MP clearance therapy on the basis of routine ITP therapy. The clinical effect， recurrence rate and the probability of turning to refractory or chronic ITP in two groups of children with ITP were compared. Results There was no significant difference in the total effective rate between the experimental group (86.21%) and the control group (82.76%) (P>0.05). In the experimental group， the recurrence rates were 3.45% and 13.79% at 6 months and 1 year after treatment， respectively， which were lower than those in the control group (20.69%， 37.93%)， the differences were statistically significant (P<0.05). The probability of turning to refractory or chronic ITP in the experimental group was 3.45%， which was significantly lower than that in the control group (17.24%)， and the difference was statistically significant (P<0.05). Conclusion Different courses of MP clearance therapy have no significant effect on the short-term curative effect of acute ITP children， but 2 to 3 courses of treatment can reduce the recurrence rate of ITP and the probability of turning to refractory or chronic ITP， and improve the prognosis of the children., http://www.100md.com(张小雯 周帆 樊小燕)
[关键词]免疫性性血小板减少性紫癜;肺炎支原体感染;不同疗程;复发率
[中图分类号] R554.6 [文献标识码] A [文章编号] 1674-4721(2019)9(a)-0118-03
Effect of different courses of Mycoplasma Pneumoniae clearance on immune thrombocytopenic purpura in children
ZHANG Xiao-wen ZHOU Fan FAN Xiao-yan
Department of Infant Medicine， Jiujiang Maternal and Child Health Hospital， Jiangxi Province， Jiujiang 332000， China
[Abstract] Objective To compare the effect of different courses of Mycoplasma Pneumoniae (MP) clearance on immune thrombocytopenic purpura (ITP) in children. Methods From January 2017 to January 2018， 58 ITP children with positive serum MP-IgM antibody were selected. They were divided into experimental group and reference group by random number table method， with 29 cases in each group. The control group was given one course of MP clearance therapy on the basis of routine ITP therapy， while the experimental group was given 2 to 3 courses of MP clearance therapy on the basis of routine ITP therapy. The clinical effect， recurrence rate and the probability of turning to refractory or chronic ITP in two groups of children with ITP were compared. Results There was no significant difference in the total effective rate between the experimental group (86.21%) and the control group (82.76%) (P>0.05). In the experimental group， the recurrence rates were 3.45% and 13.79% at 6 months and 1 year after treatment， respectively， which were lower than those in the control group (20.69%， 37.93%)， the differences were statistically significant (P<0.05). The probability of turning to refractory or chronic ITP in the experimental group was 3.45%， which was significantly lower than that in the control group (17.24%)， and the difference was statistically significant (P<0.05). Conclusion Different courses of MP clearance therapy have no significant effect on the short-term curative effect of acute ITP children， but 2 to 3 courses of treatment can reduce the recurrence rate of ITP and the probability of turning to refractory or chronic ITP， and improve the prognosis of the children., http://www.100md.com(张小雯 周帆 樊小燕)