非甾体抗炎药在中医骨伤科中运用的合理性研究(1)
[摘要]目的 分析非甾体抗炎药(NSAIDs)在我院中医骨伤科中应用的合理性。方法 回顾性分析2018年10月～2019年6月我院中医骨伤科门诊患者300例、住院患者200例，对NSAIDs使用情况进行统计分析。结果 骨关节炎(33.60%)、颈肩腰腿痛(27.40%)、骨折(31.40%)是患者服用NSAIDs的主要原因;萘普生钠注射液、醋氯芬酸钠片、洛索洛芬钠片、双氯芬酸钠缓释片是NSAIDs中消耗金额的前4位;萘普生钠注射液、醋氯芬酸钠片、洛索洛芬钠片、双氯芬酸钠缓释片是用药频率DDs前四位;消化不良、转氨酶升高、上腹疼痛、腹泻等消化系统反应是NSAIDs的最常见的不良反应。结论 我院中医骨伤科NSAIDs的临床应用较为合理，基本符合规定，应对现有NSAIDs加强不良反应监测。
[关键词]非甾体抗炎药;中医骨伤科;消耗金额;用药频度
[中图分类号] R969 [文献标识码] A [文章编号] 1674-4721(2019)10(a)-0114-03
[Abstract] Objective To analyze the rationality of non-steroidal anti-inflammatory drugs (NSAIDs) in orthopedic department of traditional Chinese medicine in our hospital. Methods All retrospectivelly 300 cases of outpatients and 200 cases of inpatients and who were treated in our hospital from October 2018 to June 2019 were retrospectively analyzed， and the use of NSAIDs were counted and analyzed. Results The Osteoarthritis (33.60%)， neck， shoulder， waist and leg pain (27.40%) and fracture (31.40%) were the main reasons for taking NSAIDs. The Naproxen Sodium Injection， Sodium Acetate Tablets， Losoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were the top four consumption amount in NSAIDs; Naproxen Sodium Injection， Sodium Acetate， Loxoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were top four DDs in drug frequency. The dyspepsia， elevated transaminase， upper abdominal pain， diarrhea and other digestive system reactions were the most common adverse reaction of NSAIDs. Conclusion The clinical application of NSAIDs in our hospital are reasonable， it is basically in line with the regulations， thus the adverse reaction monitoring should be strengthened for existing NSAIDs.
[Key words] Non-steroidal anti-inflammatory drugs; Department of orthopedics in traclitional Chinese medicine; Consumption amount; Frequency of medication
非甾體抗炎药(NSAIDs)是急、慢性风湿性疾病的非类固醇一线治疗药物，具抗炎、镇痛和解热等作用，主要用于炎症免疫性疾病的对症治疗，且无成瘾性和依赖性，是临床医师特别是骨科医师应用较多的药物之一[1-2]。中医骨伤科是研究防治人体皮、肉、筋、骨损伤与疾患的一门科学，是祖国医学重要的组成部分。因NSAIDs临床效果显著，其在中医骨伤科临床中的应用最常见、最基础，但其长期使用或不规范使用，可导致上消化道出血、肝肾毒性、药物过敏等不良反应，危及患者生命[3-4]。本研究通过分析NSAIDs在本院中医骨伤科的使用情况，分析NSAIDs应用的有效性、安全性、合理性，从而用于指导和规范NSAIDs的使用，尽量减少此类药物不良反应，提高临床用药的安全性和有效性。
1资料与方法
1.1一般资料
本研究经医院医学伦理委员会审核批准，回顾性分析2018年10月～2019年6月我院中医骨伤科门诊患者300例、住院患者200例。
1.2方法
将信息录入Excel表中，建立数据库，并采用WHO建议的限定日剂量(DDD)作为药物利用研究分析的测量单位，各种药品的DDD值参考《新编药物学》(17版)[5]并结合药品说明书和临床实际用药情况确定。
1.3观察指标, http://www.100md.com(江志勇 许楚宏 陈海燕 庄鹏)
[关键词]非甾体抗炎药;中医骨伤科;消耗金额;用药频度
[中图分类号] R969 [文献标识码] A [文章编号] 1674-4721(2019)10(a)-0114-03
[Abstract] Objective To analyze the rationality of non-steroidal anti-inflammatory drugs (NSAIDs) in orthopedic department of traditional Chinese medicine in our hospital. Methods All retrospectivelly 300 cases of outpatients and 200 cases of inpatients and who were treated in our hospital from October 2018 to June 2019 were retrospectively analyzed， and the use of NSAIDs were counted and analyzed. Results The Osteoarthritis (33.60%)， neck， shoulder， waist and leg pain (27.40%) and fracture (31.40%) were the main reasons for taking NSAIDs. The Naproxen Sodium Injection， Sodium Acetate Tablets， Losoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were the top four consumption amount in NSAIDs; Naproxen Sodium Injection， Sodium Acetate， Loxoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were top four DDs in drug frequency. The dyspepsia， elevated transaminase， upper abdominal pain， diarrhea and other digestive system reactions were the most common adverse reaction of NSAIDs. Conclusion The clinical application of NSAIDs in our hospital are reasonable， it is basically in line with the regulations， thus the adverse reaction monitoring should be strengthened for existing NSAIDs.
[Key words] Non-steroidal anti-inflammatory drugs; Department of orthopedics in traclitional Chinese medicine; Consumption amount; Frequency of medication
非甾體抗炎药(NSAIDs)是急、慢性风湿性疾病的非类固醇一线治疗药物，具抗炎、镇痛和解热等作用，主要用于炎症免疫性疾病的对症治疗，且无成瘾性和依赖性，是临床医师特别是骨科医师应用较多的药物之一[1-2]。中医骨伤科是研究防治人体皮、肉、筋、骨损伤与疾患的一门科学，是祖国医学重要的组成部分。因NSAIDs临床效果显著，其在中医骨伤科临床中的应用最常见、最基础，但其长期使用或不规范使用，可导致上消化道出血、肝肾毒性、药物过敏等不良反应，危及患者生命[3-4]。本研究通过分析NSAIDs在本院中医骨伤科的使用情况，分析NSAIDs应用的有效性、安全性、合理性，从而用于指导和规范NSAIDs的使用，尽量减少此类药物不良反应，提高临床用药的安全性和有效性。
1资料与方法
1.1一般资料
本研究经医院医学伦理委员会审核批准，回顾性分析2018年10月～2019年6月我院中医骨伤科门诊患者300例、住院患者200例。
1.2方法
将信息录入Excel表中，建立数据库，并采用WHO建议的限定日剂量(DDD)作为药物利用研究分析的测量单位，各种药品的DDD值参考《新编药物学》(17版)[5]并结合药品说明书和临床实际用药情况确定。
1.3观察指标, http://www.100md.com(江志勇 许楚宏 陈海燕 庄鹏)