当前位置: 首页 > 期刊 > 《中国医学创新》 > 2012年第10期 > 正文
编号:12281221
小剂量氯胺酮对全麻围手术期免疫功能的影响(2)
http://www.100md.com 2012年4月5日 孙天小 韩树海
第1页

    参见附件。

     综上所述,本研究结果表明,全麻诱导前给予小剂量KTM会减弱IL-6和TNF-α表达,同时维持IL-2在手术前的水平,提示小剂量KTM在防止全麻术后早期免疫功能受损中具有重要价值。

    参考文献

    [1] Dinarello C A.Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock[J].Chest,1997,112(1): 321-327.

    [2] Beilin B,Shavit Y,Trabekin E,et al.The effects of postoperative pain management on immune response to surgery[J].Anesth Analg,2003,97(1):822-827.

    [3] Cherry D A,Plummer J L,Gourlay G K,et al.Ketamine as an adjunct to morphine in treatment of pain[J].Pain,1995,62(1):119-121.

    [4] Tverskoy M,Oz Y,Isakson A,et al.Preemptive effect of fentanyl and ketamine on postoperative pain and wound analgesia[J].Anesth Analg,1994,78(1):205-209.

    [5] Roytblat L,Korotkoruchko A,Katz J, et al.Postoperative pain: the effect of low-dose ketamine in addition to general anesthesia[J].Anesth Analg,1993,77(1):1161-1163.

    [6] Roytblat L,Talmor D,Rachinsky M,et al.Ketamine attenuates the interleukin-6 response after cardiopulmary bypass[J].Anesth Analg,1998,87(2):266-271.

    [7] Taniguchi T,Takemoto Y,Kanakura H,et al.The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats[J].Anesth Analg,2003,97(2):1769-1772.

    [8] Roytblat L,Roy-Shapira A,Geemberg L,et al.Preoperative low dose ketamine reduces serum interleukin-6 response after abdominal hys- terectomy[J].Pain Clin,1996,9(2):327-334.

    [9] Xia JG,Peng J,Xiao H,et al.Effect of intravenous patient-controlled intravenous analgesia with small dose of keta-mine during shock stage on cytokine balance in patients with severe burn[J] ......

您现在查看是摘要介绍页,详见PDF附件(3662kb)