奥替溴铵单用及联用草酸艾司西酞普兰治疗肠易激综合征疗效观察(1)
【摘要】 目的：观察奥替溴铵联合草酸艾司西酞普兰治疗肠易激综合征(IBS)的疗效。方法：按罗马Ⅲ诊断标准选择60例肠易激综合征患者，按就诊顺序奇偶数分组，奇数为研究组，偶数为对照组，各30例。入组前均进行肠易激综合征症状严重程度量表(IBS-SSS)评分，入组后12周内两组均给予奥替溴铵40 mg，tid，研究组联用草酸艾司西酞普兰10 mg/d；12周后，研究组继续服用草酸艾司西酞普兰至24周，两组在12～24周期间均根据腹痛情况按需服用奥替溴铵(不作常规服用)。分别在治疗2、4、8、12、24周末各评定一次治疗效果。结果：治疗第2、4、8、12、24周末研究组IBS-SSS评分依次为(185.00±38.24)分、(149.07±38.30)分、(127.83±37.51)分、(112.97±37.55)分、(102.97±43.82)分，对照组评分依次为(226.80±42.98)分、(183.33±41.90)分、(165.33±37.19)分、(152.30±39.41)分、(147.57±41.46)分，两组比较差异均有统计学意义(P<0.01)。结论：联合使用草酸艾司西酞普兰和奥替溴铵更能缓解患者的腹痛、腹部不适症状及排便异常现象，并能提高患者的生活质量，疗效持久，安全耐受性好，持续用药复发风险小。
, 百拇医药
【关键词】 肠易激综合征； 草酸艾司西酞普兰； 奥替溴铵
【Abstract】 Objective： To observe the effect of Otilonium bromide combined with Oxalic acid Ai Sciplan in the treatment of irritable bowel syndrome (IBS). Method： 60 cases with irritable bowel syndrome were selected according to the Rome Ⅲ diagnosis criteria， they were grouped by the visit order of odd and even， odd as the research group， even for the control group， 30 cases in each group. Before entering the group ，they were score by irritable bowel syndrome severity scale (IBS-SSS)， when enrolled the two groups were given otilonium bromide 40 mg，tid， the research group in conjunction with oxalic acid Ai Sciplan 10 mg/d within 12 weeks. After 12 weeks， the research group continues taking escitalopram oxalate to 24 weeks， the two groups used otilonium bromide according to abdominal pain duringon-demand during 12 to 24 weeks (not as a conventional take). Result： The treatment effect was evaluated respectively at the end of 2， 4， 8， 12， 24 weeks， and the IBS-SSS scores of the research group were (185.00±38.24)， (149.07±38.30)， (127.83±37.51)， (112.97±37.55)， (102.97±43.82)， the control group scores were (226.80±42.98)， (183.33±41.90)， (165.33±37.19)， (152.30±39.41)， (147.57±41.46)， followed by the two groups， the control group scores were significantly different (P<0.01). Conclusion： Joint use of escitalopram oxalate and otilonium bromide can ease patients abdominal pain， abdominal discomfort and abnormal bowel movements， improve the quality of life of patients at the same time. This method has lasting efficacy， safety， well tolerated， and small relapse risk when sustained drug use.
, 百拇医药
【Key words】 Irritable bowel syndrome； Escitalopram oxalate； Otilonium bromide
First-author’s address： Yichun People’s Hospital， Yichun 336000， China
doi：10.3969/j.issn.1674-4985.2015.01.001
肠易激综合征(irritable bowel syndrome， IBS)是一种功能性肠病，其腹痛或腹部不适伴随排便或排便习惯的改变，具有排便异常的特征。其病因及发病机理尚不完全清楚，目前尚无规范治疗方案，单用解痉药和调节胃肠道功能药效果有一定的局限性。本研究使用奥替溴铵联用草酸艾司西酞普兰能起到症状明显减轻的效果，并且疗效持久，安全性、耐受性好，持续用药复发风险小，现报道如下。, 百拇医药(周海平等)
, 百拇医药
【关键词】 肠易激综合征； 草酸艾司西酞普兰； 奥替溴铵
【Abstract】 Objective： To observe the effect of Otilonium bromide combined with Oxalic acid Ai Sciplan in the treatment of irritable bowel syndrome (IBS). Method： 60 cases with irritable bowel syndrome were selected according to the Rome Ⅲ diagnosis criteria， they were grouped by the visit order of odd and even， odd as the research group， even for the control group， 30 cases in each group. Before entering the group ，they were score by irritable bowel syndrome severity scale (IBS-SSS)， when enrolled the two groups were given otilonium bromide 40 mg，tid， the research group in conjunction with oxalic acid Ai Sciplan 10 mg/d within 12 weeks. After 12 weeks， the research group continues taking escitalopram oxalate to 24 weeks， the two groups used otilonium bromide according to abdominal pain duringon-demand during 12 to 24 weeks (not as a conventional take). Result： The treatment effect was evaluated respectively at the end of 2， 4， 8， 12， 24 weeks， and the IBS-SSS scores of the research group were (185.00±38.24)， (149.07±38.30)， (127.83±37.51)， (112.97±37.55)， (102.97±43.82)， the control group scores were (226.80±42.98)， (183.33±41.90)， (165.33±37.19)， (152.30±39.41)， (147.57±41.46)， followed by the two groups， the control group scores were significantly different (P<0.01). Conclusion： Joint use of escitalopram oxalate and otilonium bromide can ease patients abdominal pain， abdominal discomfort and abnormal bowel movements， improve the quality of life of patients at the same time. This method has lasting efficacy， safety， well tolerated， and small relapse risk when sustained drug use.
, 百拇医药
【Key words】 Irritable bowel syndrome； Escitalopram oxalate； Otilonium bromide
First-author’s address： Yichun People’s Hospital， Yichun 336000， China
doi：10.3969/j.issn.1674-4985.2015.01.001
肠易激综合征(irritable bowel syndrome， IBS)是一种功能性肠病，其腹痛或腹部不适伴随排便或排便习惯的改变，具有排便异常的特征。其病因及发病机理尚不完全清楚，目前尚无规范治疗方案，单用解痉药和调节胃肠道功能药效果有一定的局限性。本研究使用奥替溴铵联用草酸艾司西酞普兰能起到症状明显减轻的效果，并且疗效持久，安全性、耐受性好，持续用药复发风险小，现报道如下。, 百拇医药(周海平等)