【摘要】 目的：研究早发型(孕周<32周)及晚发型(孕周≥32周)子痫前期患者胎盘中NF-κB的活性强度。方法：选择子痫前期患者40例，其中早发型患者20例为早发型子痫前期组，晚发型患者20例为晚发型子痫前期组；正常足月妊娠孕妇30例为对照组。用免疫组化法观察各组胎盘NF-κBp65的分布和活性强度的差异。结果：子痫前期组胎盘NF-κBp65染色均较正常组明显增强，且早发型组较晚发型组染色明显增强，两组比较差异有统计学意义(P<0.05)。结论：早发型和晚发型子痫前期患者胎盘NF-κB活化增多，活性增强，及其所参与的免疫炎症反应，可能与其发病机制相关。

    【关键词】 早发型及晚发型子痫前期； 核因子–κB； 胎盘

    【Abstract】 Objective： To explore the relationship of NF-κB in placenta with early-onset (gestational age <32 weeks)and late-onset(gestational age ≥32 weeks)preeclampsia. Method：40 PE women were selected and divided into early-onset PE group of 20 cases and late-onset PE group of 20 cases.The normal control group were 30 healthy normotensive pregnancy.Immunohistochemistry was employed to show the location distribution and quantity of NF-κBp65 in placenta of preeclampsia. Result：NF–κBp65 in placenta of preeclampsia was stronger expression than that of control group ......