小儿肺咳合剂对咳嗽变异性哮喘患儿肺功能、血清IgE及外周血EOS的影响(1)
【摘要】 目的：探讨小儿肺咳合剂对咳嗽变异性哮喘患儿肺功能、血清IgE及外周血EOS的影响。方法：回顾性选取本院2010年10月-2013年10月收治的100例儿童咳嗽变异性哮喘患者作为研究对象，将其随机分为观察组和对照组，每组各50例。对照组均给予常规治疗，观察组在对照组基础上，同时给予小儿肺咳合剂，1剂/d，两组患者均以4周为一疗程。观察并比较两组患者治疗后的咳嗽频率和咳嗽强度症状、记录他们的体征积分，比较治疗前后两组患者的肺功能和血清IgE及外周血EOS。结果：治疗后，观察组治疗总有效率高于对照组，患儿症状积分及肺功能改善情况均显著优于对照组，两组比较差异均有统计学意义(P<0.05)；治疗后两组患者血清IgE及外周血EOS都得到显著降低，且观察组的测量值明显低于对照组，两组患者的疗效比较差异有统计学意义(P<0.05)。结论：小儿肺咳合剂能抗变应性炎症，降低气道的高反应性，治疗儿童咳嗽变异性哮喘疗效显著。
【关键词】 小儿肺咳合剂； 咳嗽变异性哮喘； 血清IgE； 肺功能； 外周血EOS
, 百拇医药
The Influence of Pediatric Cough Mixture for Children with Cough Variant Asthma on Lung Function，Serum IgE and Peripheral Blood EOS/YUAN Zhao-hong，YOU Yu-hui，JIANG Xiu-fang，et al.//Medical Innovation of China，2015，12(18)：058-061
【Abstract】 Objective：To investigate the effect of infantile cough mixture for children with cough variant asthma on lung function，serum IgE and peripheral blood EOS.Method：100 children with cough variant asthma in our hospital were selected from October 2010 to October 2013 as the research objects，they were randomly divided into observation group and control group，50 cases in each group.The control group was given conventional treatment，the observation group on the basis of that was given cough mixture，one day a dose，two groups were in a course of 4 weeks.After treatment，the frequency of cough and cough symptom intensity of two groups were observed and compared，their signs points were recorded；before and after the treatment，the pulmonary function，serum IgE and EOS in peripheral blood of two groups were compared.Result：After treatment，the total effective rate of observation group was higher than the control group，symptoms and lung function improvement were significantly better than the control group，the differences were statistically significant(P<0.05)；after the treatment，the patients in the two groups of serum IgE and EOS in peripheral blood were significantly reduced，and the value of measurement of the observation group was significantly lower than the control group，the differences were statistically significant(P<0.05).Conclusion：Children with cough mixture can anti allergic inflammation，reduce airway hyperresponsiveness，significant treatment children cough variant asthma.
, 百拇医药
【Key words】 Infantile cough mixture； Cough variant asthma； Serum IgE； Pulmonary function； Peripheral blood EOS
First-author’s address：Affiliated Hospital of Ji’ning Medical University，Ji’ning 272029，China
doi：10.3969/j.issn.1674-4985.2015.18.021
咳嗽变异性哮喘(CVA)是哮喘病中的一种特殊类型，其主要表现为长期反复性干咳症状，气道高反应性，无明显喘息症状。此类疾病常见于儿童群体，其比例占儿童慢性咳嗽疾病的34%[1]。此疾病具有持续性、反复性和顽固性的特征，此疾病很难完全治愈，因此该疾病对患儿的身体健康和生活质量产生很大的影响。目前，通常采用糖皮质激素、支气管扩张剂和白三烯受体拮抗剂这几类药物治疗咳嗽变异性哮喘患者，但长期应用这些药物可给患儿带来一定的副作用，同时这几类药物不能够根治此疾病，还存在易复发的症状。近年来，随着医学人士的不断研究实践证明，采用中药治疗咳嗽变异性哮喘病可取得显著的疗效，且采用中药治疗的稳定性较强、药物副作用小[2]。为此本文将选取本院2010年10月-2013年10月收治的100例儿童咳嗽变异性哮喘患者作为研究对象，探讨小儿肺咳合剂对咳嗽变异性哮喘患儿肺功能、血清IgE及外周血EOS的影响，现报告如下。, 百拇医药(袁兆红 尤玉慧 姜秀芳 王瑜 李庆宜)
【关键词】 小儿肺咳合剂； 咳嗽变异性哮喘； 血清IgE； 肺功能； 外周血EOS
, 百拇医药
The Influence of Pediatric Cough Mixture for Children with Cough Variant Asthma on Lung Function，Serum IgE and Peripheral Blood EOS/YUAN Zhao-hong，YOU Yu-hui，JIANG Xiu-fang，et al.//Medical Innovation of China，2015，12(18)：058-061
【Abstract】 Objective：To investigate the effect of infantile cough mixture for children with cough variant asthma on lung function，serum IgE and peripheral blood EOS.Method：100 children with cough variant asthma in our hospital were selected from October 2010 to October 2013 as the research objects，they were randomly divided into observation group and control group，50 cases in each group.The control group was given conventional treatment，the observation group on the basis of that was given cough mixture，one day a dose，two groups were in a course of 4 weeks.After treatment，the frequency of cough and cough symptom intensity of two groups were observed and compared，their signs points were recorded；before and after the treatment，the pulmonary function，serum IgE and EOS in peripheral blood of two groups were compared.Result：After treatment，the total effective rate of observation group was higher than the control group，symptoms and lung function improvement were significantly better than the control group，the differences were statistically significant(P<0.05)；after the treatment，the patients in the two groups of serum IgE and EOS in peripheral blood were significantly reduced，and the value of measurement of the observation group was significantly lower than the control group，the differences were statistically significant(P<0.05).Conclusion：Children with cough mixture can anti allergic inflammation，reduce airway hyperresponsiveness，significant treatment children cough variant asthma.
, 百拇医药
【Key words】 Infantile cough mixture； Cough variant asthma； Serum IgE； Pulmonary function； Peripheral blood EOS
First-author’s address：Affiliated Hospital of Ji’ning Medical University，Ji’ning 272029，China
doi：10.3969/j.issn.1674-4985.2015.18.021
咳嗽变异性哮喘(CVA)是哮喘病中的一种特殊类型，其主要表现为长期反复性干咳症状，气道高反应性，无明显喘息症状。此类疾病常见于儿童群体，其比例占儿童慢性咳嗽疾病的34%[1]。此疾病具有持续性、反复性和顽固性的特征，此疾病很难完全治愈，因此该疾病对患儿的身体健康和生活质量产生很大的影响。目前，通常采用糖皮质激素、支气管扩张剂和白三烯受体拮抗剂这几类药物治疗咳嗽变异性哮喘患者，但长期应用这些药物可给患儿带来一定的副作用，同时这几类药物不能够根治此疾病，还存在易复发的症状。近年来，随着医学人士的不断研究实践证明，采用中药治疗咳嗽变异性哮喘病可取得显著的疗效，且采用中药治疗的稳定性较强、药物副作用小[2]。为此本文将选取本院2010年10月-2013年10月收治的100例儿童咳嗽变异性哮喘患者作为研究对象，探讨小儿肺咳合剂对咳嗽变异性哮喘患儿肺功能、血清IgE及外周血EOS的影响，现报告如下。, 百拇医药(袁兆红 尤玉慧 姜秀芳 王瑜 李庆宜)