【摘要】 目的：探讨阿托伐他汀对糖尿病肾病患者血同型半胱氨酸、纤维蛋白原水平的影响。方法：选取50例确诊为糖尿病肾病的患者，根据血脂水平分为A组(血脂正常组)和B组(血脂升高组)；A组随机数字表法分为对照组(A1组)和治疗组(A2组)。A1组、A2组及B组均给予糖尿病基础治疗。A2组和B组在糖尿病基础治疗上增加口服阿托伐他汀。比较各组患者治疗前后的血同型半胱氨酸、纤维蛋白原水平等指标的改变。结果：A组治疗前血同型半胱氨酸(Hcy)及纤维蛋白原均低于B组(P<0.05)，A1、A2组患者治疗前Hcy及纤维蛋白原无明显差异，A2组治疗后Hcy水平及纤维蛋白原均低于A1组(P<0.05)，B组治疗后Hcy水平及纤维蛋白原均显著降低(P<0.05)。结论：阿托伐他汀能降低糖尿病肾病患者血同型半胱氨酸、纤维蛋白原水平，发挥降血脂以外的血管保护作用，以延缓糖尿病肾病进展。

    【关键词】 阿托伐他汀； 糖尿病肾病； 同型半胱氨酸； 纤维蛋白原

    【Abstract】 Objective：To investigate the effect of atorvastatin on blood homocysteine and fibrinogen level in patients with diabetic nephropathy.Method：50 cases who were diagnosed with diabetic nephropathy were divided into group A (normal lipid group) and group B (elevated blood lipids group) according to their lipid levels.The A group were randomly divided into control group (A1 group) and treatment group (A2 group).Group A1 ......