钙蛋白酶抑制剂减少大鼠局灶性脑缺血再灌注模型海马CA1区神经元凋亡(4)
[5] Ding Z J，Chen X，Tang X X，et al.Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro[J].PloS One，2015，10(4)：e0123130.
[6] Park J Y，Jang S Y，Shin Y K，et al.Calcium-dependent proteasome activation is required for axonal neurofilament degradation[J].Neural Regen Res，2013，8(36)：3401-3409.
[7] Jordan J，Galindo M F，Miller R J.Role of calpain and interleukin-1-beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture[J].J Neurochem，1997，68(4)：1612-1621.
[8] Peng S，Kuang Z，Zhang Y，et al.The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focalcerebral ischemia-reperfusion injury in rats[J].Mol Biol Rep，2011，38(2)：905-912.
[9] Yamashima T，Tonchev A B，Tsukada T，et al.Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic ca1 neurons in primates[J].Hippocampus，2003，13(7)：791-800.
[10] Müller G J，Hasseldam H，Rasmussen R S，et al.Dexamethasone enhances necrosis-like neuronal death in ischemic rat hippocampus involving μ-calpain activation[J].Exp Neurol，2014，261(1)：711-719.
[11] Jordan J，Galindo M F，Miller R J.Role of calpain and interleukin-1-beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture[J].J Neurochem，1997，68(4)：1612-1621.
[12] Li H，Zhang N，Sun G，et al.Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia[J].ASN Neuro，2013，5(3)：195-207.
[13] Kim C，Yun N，Lee Y M，et al.Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell[J].J Biol Chem，2013，288(51)：36 717-36 732.
[14] Song Y J，Li D，Pan L P，et al.The suppression of epileptiform discharges in cultured hippocampal neurons is regulated via alterations in full-length tropomyosin-related kinase type B receptors signalling activity[J].The European Journal of Neuroscience，2014，40(3)：2564-2575.
[15] Samantaray S，Patel K S，Knaryan V H，et al.Calpain inhibition prevents ethanol-induced alterations in spinal motoneurons[J].Neurochem Res，2013，38(8)：1734-1741.
(收稿日期：2015-07-03) (本文编辑：王利), http://www.100md.com(匡重伸 许航 黄征 朱桂云 王胜)
[6] Park J Y，Jang S Y，Shin Y K，et al.Calcium-dependent proteasome activation is required for axonal neurofilament degradation[J].Neural Regen Res，2013，8(36)：3401-3409.
[7] Jordan J，Galindo M F，Miller R J.Role of calpain and interleukin-1-beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture[J].J Neurochem，1997，68(4)：1612-1621.
[8] Peng S，Kuang Z，Zhang Y，et al.The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focalcerebral ischemia-reperfusion injury in rats[J].Mol Biol Rep，2011，38(2)：905-912.
[9] Yamashima T，Tonchev A B，Tsukada T，et al.Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic ca1 neurons in primates[J].Hippocampus，2003，13(7)：791-800.
[10] Müller G J，Hasseldam H，Rasmussen R S，et al.Dexamethasone enhances necrosis-like neuronal death in ischemic rat hippocampus involving μ-calpain activation[J].Exp Neurol，2014，261(1)：711-719.
[11] Jordan J，Galindo M F，Miller R J.Role of calpain and interleukin-1-beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture[J].J Neurochem，1997，68(4)：1612-1621.
[12] Li H，Zhang N，Sun G，et al.Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia[J].ASN Neuro，2013，5(3)：195-207.
[13] Kim C，Yun N，Lee Y M，et al.Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell[J].J Biol Chem，2013，288(51)：36 717-36 732.
[14] Song Y J，Li D，Pan L P，et al.The suppression of epileptiform discharges in cultured hippocampal neurons is regulated via alterations in full-length tropomyosin-related kinase type B receptors signalling activity[J].The European Journal of Neuroscience，2014，40(3)：2564-2575.
[15] Samantaray S，Patel K S，Knaryan V H，et al.Calpain inhibition prevents ethanol-induced alterations in spinal motoneurons[J].Neurochem Res，2013，38(8)：1734-1741.
(收稿日期：2015-07-03) (本文编辑：王利), http://www.100md.com(匡重伸 许航 黄征 朱桂云 王胜)