磷酸化表皮生长因子受体与鼻咽癌患者预后关系的研究(3)
本研究的结果显示，两组3年总生存率与无进展生存率比较，差异均无统计学意义(P>0.05)，阴性组3年无局部复发生存率高于阳性组，比较差异有统计学意义(P=0.038)。pEGFR与患者的预后差相关联，本验的研究结果在临床方面进一步证实了pEGFR的过表达与鼻咽癌患者的局部控制差相关。这一研究结论在临床有一定的实际应用价值，可作为鼻咽癌患者预后的一个推测指标。但有关pEGFR导致鼻咽癌患者预后差的分子机制，本试验未做相关研究，可在以后的研究中进一步探索。
参考文献
[1] Lu J J，Cooper J S，Lee A W M.Nasopharyngeal cancer：multidisciplinary management[M].Germany：Springer Verlag，Heidelberg，2010：1-7.
[2]赵平.中国肿瘤临床年鉴[M].北京：中国协和医科大学出版社，2010：2.
, http://www.100md.com
[3] Heuckmann J M，Rauh D，Thomas R K.Epidermal growth factor receptor(EGFR) signaling and covalent EGFR inhibition in lung cancer[J].Clin Oncol，2012，30(27)∶3417-3420.
[4] Sarkis S A，Abdullah B H，Majeed B A，et al.Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation，apoptosis，angiogenesis and lymphangiogenesis[J].Head Neck Oncol，2010，2(13)：1-8.
[5] Chua D T，Nicholls J M，Sham J S，et al.Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy[J].Int J Radiation Oncology Biol Phys，2004，59(1)：11-20.
, 百拇医药
[6] Starska K，Glowacka E，Lewy-Trenda I，et al.EGFR immunoexpression and peripheral blood cytokine secretion as potential biomarkers of tumor behavior in laryngeal squamous cell carcinoma[J].Med Sci Monit，2009，15(10)：518-527.
[7]张小鹏，边枫，王丽新.环氧合酶-2及表皮生长因子受体在鼻咽癌中的表达及相关性[J].山东大学耳鼻喉眼学报，2014，28(3)：23-27.
[8] Wissing J，Jansch L，Nimtz M，et al.Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry[J].Mol Cell Proteomics，2007，6(3)：537-547.
, http://www.100md.com
[9] Knight Z A，Schilling B，Row R H，et al.Phosphospecific proteolysis for mapping sites of protein phosphorylation[J].Nat Biotechnol，2003，21(9)：1047-1054.
[10] McLachlin D T，Chait B T.Improved beta-elimination-based affinity purification strategy for enrichment of phosphopeptides[J].Anal Chem，2003，75(24)：6826-6836.
[11] Tseng H C，Ovaa H，Wei N J，et al.Phosphoproteornic analysis with a solid-phase capture-release-tag approach[J].Chem Biol，2005，12(7)：769-777.
, 百拇医药
[12] Sonnweber B，Dlaska M，Skvortsov S，et al.Highpredictive value of epidermal growth factor receptor phosphorylation but not of EGFR vmutationin resected stage non-smallcell lung cancer(NSCLC)[J].J Clin Pathol，2006，59(3)：255-259.
[13] Ma B B，Poon T C，To K F，et al.Prognostic significance of tumor angiogenesis，Ki67，p53 oncoprotein，epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal lcarcinoma-a prospective study[J].Head Neck，2003，25(10)：864-872.
[14]袁太泽，李晓霞，曹云.表皮生长因子受体活化与鼻咽癌患者无转移生存的关系[J].癌症，2008，27(5)：449-454.
[15] Leong J L，Loh K S，Putti T C，et al.Epidermal growth factor receptor in undifferentiated carcinoma of the nasopharynx[J].Laryngoscope，2004，114(1)：153-157.
(收稿日期：2015-08-04) (本文编辑：王利), http://www.100md.com(吴伟)
参考文献
[1] Lu J J，Cooper J S，Lee A W M.Nasopharyngeal cancer：multidisciplinary management[M].Germany：Springer Verlag，Heidelberg，2010：1-7.
[2]赵平.中国肿瘤临床年鉴[M].北京：中国协和医科大学出版社，2010：2.
, http://www.100md.com
[3] Heuckmann J M，Rauh D，Thomas R K.Epidermal growth factor receptor(EGFR) signaling and covalent EGFR inhibition in lung cancer[J].Clin Oncol，2012，30(27)∶3417-3420.
[4] Sarkis S A，Abdullah B H，Majeed B A，et al.Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation，apoptosis，angiogenesis and lymphangiogenesis[J].Head Neck Oncol，2010，2(13)：1-8.
[5] Chua D T，Nicholls J M，Sham J S，et al.Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy[J].Int J Radiation Oncology Biol Phys，2004，59(1)：11-20.
, 百拇医药
[6] Starska K，Glowacka E，Lewy-Trenda I，et al.EGFR immunoexpression and peripheral blood cytokine secretion as potential biomarkers of tumor behavior in laryngeal squamous cell carcinoma[J].Med Sci Monit，2009，15(10)：518-527.
[7]张小鹏，边枫，王丽新.环氧合酶-2及表皮生长因子受体在鼻咽癌中的表达及相关性[J].山东大学耳鼻喉眼学报，2014，28(3)：23-27.
[8] Wissing J，Jansch L，Nimtz M，et al.Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry[J].Mol Cell Proteomics，2007，6(3)：537-547.
, http://www.100md.com
[9] Knight Z A，Schilling B，Row R H，et al.Phosphospecific proteolysis for mapping sites of protein phosphorylation[J].Nat Biotechnol，2003，21(9)：1047-1054.
[10] McLachlin D T，Chait B T.Improved beta-elimination-based affinity purification strategy for enrichment of phosphopeptides[J].Anal Chem，2003，75(24)：6826-6836.
[11] Tseng H C，Ovaa H，Wei N J，et al.Phosphoproteornic analysis with a solid-phase capture-release-tag approach[J].Chem Biol，2005，12(7)：769-777.
, 百拇医药
[12] Sonnweber B，Dlaska M，Skvortsov S，et al.Highpredictive value of epidermal growth factor receptor phosphorylation but not of EGFR vmutationin resected stage non-smallcell lung cancer(NSCLC)[J].J Clin Pathol，2006，59(3)：255-259.
[13] Ma B B，Poon T C，To K F，et al.Prognostic significance of tumor angiogenesis，Ki67，p53 oncoprotein，epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal lcarcinoma-a prospective study[J].Head Neck，2003，25(10)：864-872.
[14]袁太泽，李晓霞，曹云.表皮生长因子受体活化与鼻咽癌患者无转移生存的关系[J].癌症，2008，27(5)：449-454.
[15] Leong J L，Loh K S，Putti T C，et al.Epidermal growth factor receptor in undifferentiated carcinoma of the nasopharynx[J].Laryngoscope，2004，114(1)：153-157.
(收稿日期：2015-08-04) (本文编辑：王利), http://www.100md.com(吴伟)