【摘要】 脓毒血症已成为世界范围内死亡和病危的主要原因，目前对脓毒症的发病机制还不是十分清楚，现有的治疗效果也不甚理想，为此已设置出多种脓毒症相关的模型。肾脏是最易受到脓毒症打击的靶器官之一，本文对脓毒症大鼠模型中右美托咪啶的肾脏保护作用研究现状和进展做一综述，并对今后的研究提出展望。

    【关键词】 脓毒症； 右美托咪啶； 肾脏保护； 研究进展

    【Abstract】 Sepsis is a main problem for dead all over the world.The mechanism of sepsis is not clearly by far，beside the existing treatment effect is not very ideal.So there are variety of animal models of sepsis， which make us studying sepsis deeply.Kidney is one of the organs which are impaired most easily.This paper do a review for the research status and progress of dexmedetomidine renal protective effect on sepsis rats model.

    【Key words】 Sepsis； Dexmedetomidine； Renal protection； Research status and progress

    First-author’s address：Huizhou First Hospital ......