曲美他嗪联合麝香保心丸对冠心病患者心率变异性和心律失常的疗效观察(1)
【摘要】 目的：探讨曲美他嗪联合麝香保心丸对冠心病患者心率变异性和心律失常的临床疗效。方法：选取2015年6月-2016年6月在本院接受治疗的冠心病患者120例，按照随机数字表法分为联合组和对照组，每组60例，对照组给予常规药物治疗，联合组在对照组的基础上给予曲美他嗪联合麝香保心丸治疗12周，随访结束后，分析两组治疗前后的心率变异性指标、心功能检测指标、心絞痛发作次数、持续时间以及心律失常发生率。结果：经过对比发现，联合组治疗前的心率变异性指标以及心功能检测指标、心绞痛发作次数、持续时间与对照组相比，差异均无统计学意义(P>0.05)。治疗后的心率变异性指标、心功能检测指标、心绞痛发作次数、持续时间以及心律失常发生率与对照组比较，差异均有统计学意义(P<0.05)。结论：曲美他嗪联合麝香保心丸治疗冠心病的疗效显著，可有效改善患者的心功能状况以及心率变异性，降低心律失常的发生率，值得临床推广应用。
【关键词】 曲美他嗪； 麝香保心丸； 冠心病； 心率变异性； 心律失常
Effect of Trimetazidine Combined with Shexiang Baoxin Pill on Heart Rate Variability and Arrhythmia of Coronary Heart Disease Patients/SHI Ya-fei，JIANG Yi-cheng，XU Hai，et al.//Medical Innovation of China，2017，14(11)：093-096
【Abstract】 Objective：To investigate clinical curative effect of trimetazidine combined with Shexiang Baoxin Pill on heart rate variability and arrhythmia of coronary heart disease patients.Method：A total of 120 coronary heart disease patients from June 2015 to June 2016 in our hospital were selected and divided into the combination group and the control group according to random number table method，60 cases in each group.The control group was given routine drug treatment，the combination group was given Trimetazidine combined with Shexiang Baoxin Pill for 12 weeks on the basis of the control group.After follow-up，heart rate variability indexes，cardiac function test indexes，frequency and duration of angina pectoris and arrhythmia incidence of two groups before and after treatment were analysed.Result：There were no statistical significance in heart rate variability indexes，cardiac function test indexes and frequency and duration of angina pectoris of two groups before treatment(P>0.05).There were statistical significance in heart rate variability indexes，cardiac function test indexes，frequency and duration of angina pectoris and arrhythmia incidence of two groups after treatment(P<0.05).Conclusion：Trimetazidine combined with Shexiang Baoxin Pill have significant curative effect in the treatment of coronary heart disease，can effectively improve patient’s cardiac function and heart rate variability and reduce the incidence of arrhythmia，it is worthy of clinical application.
【Key words】 Trimetazidine； Shexiang Baoxin Pill； Coronary heart disease； Heart rate variability；Arrhythmia
First-author’s address：Huai’an First People’s Hospital，Huai’an 223300，China
doi：10.3969/j.issn.1674-4985.2017.11.026
冠状动脉粥样硬化性心脏病指冠状动脉粥样硬化使血管腔狭窄或阻塞，或/和因冠状动脉功能性改变(痉挛)导致心肌缺血缺氧或坏死而引起的心脏病，简称冠心病，亦称缺血性心脏病。冠心病是一种常见病、多发病，随着改革开放和人们生活水平的不断提高，我国的冠心病患病率和死亡率呈明显的上升趋势，严重危害人类健康[1]。冠心病常见症状为发作性心绞痛，主要表现为胸骨中下段压榨性疼痛，可以向左肩及左臂内侧放射，心电图可表现为ST段压低，合并各种心律失常如房室传导阻滞或束支传导阻滞、室性或房性期前收缩等，甚至发生室性心动过速、心室颤动，导致患者死亡[2]。, 百拇医药(史亚非 姜宜成 徐海 田晓沂)
【关键词】 曲美他嗪； 麝香保心丸； 冠心病； 心率变异性； 心律失常
Effect of Trimetazidine Combined with Shexiang Baoxin Pill on Heart Rate Variability and Arrhythmia of Coronary Heart Disease Patients/SHI Ya-fei，JIANG Yi-cheng，XU Hai，et al.//Medical Innovation of China，2017，14(11)：093-096
【Abstract】 Objective：To investigate clinical curative effect of trimetazidine combined with Shexiang Baoxin Pill on heart rate variability and arrhythmia of coronary heart disease patients.Method：A total of 120 coronary heart disease patients from June 2015 to June 2016 in our hospital were selected and divided into the combination group and the control group according to random number table method，60 cases in each group.The control group was given routine drug treatment，the combination group was given Trimetazidine combined with Shexiang Baoxin Pill for 12 weeks on the basis of the control group.After follow-up，heart rate variability indexes，cardiac function test indexes，frequency and duration of angina pectoris and arrhythmia incidence of two groups before and after treatment were analysed.Result：There were no statistical significance in heart rate variability indexes，cardiac function test indexes and frequency and duration of angina pectoris of two groups before treatment(P>0.05).There were statistical significance in heart rate variability indexes，cardiac function test indexes，frequency and duration of angina pectoris and arrhythmia incidence of two groups after treatment(P<0.05).Conclusion：Trimetazidine combined with Shexiang Baoxin Pill have significant curative effect in the treatment of coronary heart disease，can effectively improve patient’s cardiac function and heart rate variability and reduce the incidence of arrhythmia，it is worthy of clinical application.
【Key words】 Trimetazidine； Shexiang Baoxin Pill； Coronary heart disease； Heart rate variability；Arrhythmia
First-author’s address：Huai’an First People’s Hospital，Huai’an 223300，China
doi：10.3969/j.issn.1674-4985.2017.11.026
冠状动脉粥样硬化性心脏病指冠状动脉粥样硬化使血管腔狭窄或阻塞，或/和因冠状动脉功能性改变(痉挛)导致心肌缺血缺氧或坏死而引起的心脏病，简称冠心病，亦称缺血性心脏病。冠心病是一种常见病、多发病，随着改革开放和人们生活水平的不断提高，我国的冠心病患病率和死亡率呈明显的上升趋势，严重危害人类健康[1]。冠心病常见症状为发作性心绞痛，主要表现为胸骨中下段压榨性疼痛，可以向左肩及左臂内侧放射，心电图可表现为ST段压低，合并各种心律失常如房室传导阻滞或束支传导阻滞、室性或房性期前收缩等，甚至发生室性心动过速、心室颤动，导致患者死亡[2]。, 百拇医药(史亚非 姜宜成 徐海 田晓沂)