标准大骨瓣减压术联合亚低温治疗对大面积脑梗死患者S—100B、血糖及神经功能评分的影响(1)
【摘要】 目的：分析大面积脑梗死患者應用标准大骨瓣减压手术与亚低温联合治疗的S-100B水平、血糖和神经功能评分情况。方法：对2014年3月-2016年7月本院与协助单位(广东三九脑科医院)共选取大面积脑梗死84例患者资料加以分析，依据临床治疗时所选用的不同治疗方案分为对照组与观察组，每组42例，对照组采取常规治疗方式，观察组采取联合治疗方式，包括标准大骨瓣减压手术和亚低温，观察和对比两组S-100B水平、血糖和神经功能评分状况。结果：观察组治疗后第3、5和7天S-100B水平均比对照组低，且治疗后第5、7天血糖水平(6.72±0.70)、(5.92±0.60)mmol/L均比对照组的(10.40±0.96)、(9.40±0.70)mmol/L低，差异均有统计学意义(P<0.01)；观察组治疗后第4、12和24周神经功能评分均比对照组高，差异均有统计学意义(P<0.01)。结论：大面积脑梗死者应用标准大骨瓣减压手术与亚低温联合治疗具有显著效果，能优化患者S-100B和血糖水平，且提高神经功能，临床疗效显著，具有一定临床应用与研究价值。
【关键词】 脑梗死； 大面积； 亚低温； 标准大骨瓣减压手术； 神经功能
【Abstract】 Objective：To analyze the levels of S-100B，blood glucose and neurological function in large area cerebral infarction patients treated with standard large bone flap decompression combined with mild hypothermia.Method：From March 2014 to July 2016 in our hospital and assisting units(Guangdong Sanjiu brain hospital)，84 patients with cerebral infarction were randomly divided into the control group and the observation group which according to the different treatment regimen selected in the clinical treatment，42 cases in each group.The control group was treated by routine therapy，and the observation group was treated by combined treatment，including standard big bone flap decompression and mild hypothermia.Then levels of S-100B，blood glucose and neurological function situation of two group were compared.Result：The levels of S-100B in the observation group were significantly lower than those in the control group at 3th，5th and 7th day after treatment，and the differences were statistically significant (P<0.01).The blood glucose level of the study group were (6.72±0.70)，(5.92±0.60)mmol/L，they were significantly lower than (10.40±0.96) and (9.40±0.70)mmol/L of the control group at 5th and 7th day after treatment，and the differences were statistically significant(P<0.01).The nerve function scores of the observation group were higher than those of the control group at 4th，12th and 24th week after treatment，the differences were statistically significant(P<0.01).Conclusion：The patients with large area cerebral infarction treated by standard large bone flap decompression combined with mild hypothermia have a significant effect，which could optimize S-100B and blood glucose level，and improve the neurological function of patients.The clinical effect is significant and has certain clinical application and research value.
【Key words】 Cerebral infarction； Large area； Mild hypothermia； Standard large bone flap decompression； Neurological function, 百拇医药(朱泳鹏 杨太生 张良 陈大洋 何志深 陈明攀 洪荣庆)
【关键词】 脑梗死； 大面积； 亚低温； 标准大骨瓣减压手术； 神经功能
【Abstract】 Objective：To analyze the levels of S-100B，blood glucose and neurological function in large area cerebral infarction patients treated with standard large bone flap decompression combined with mild hypothermia.Method：From March 2014 to July 2016 in our hospital and assisting units(Guangdong Sanjiu brain hospital)，84 patients with cerebral infarction were randomly divided into the control group and the observation group which according to the different treatment regimen selected in the clinical treatment，42 cases in each group.The control group was treated by routine therapy，and the observation group was treated by combined treatment，including standard big bone flap decompression and mild hypothermia.Then levels of S-100B，blood glucose and neurological function situation of two group were compared.Result：The levels of S-100B in the observation group were significantly lower than those in the control group at 3th，5th and 7th day after treatment，and the differences were statistically significant (P<0.01).The blood glucose level of the study group were (6.72±0.70)，(5.92±0.60)mmol/L，they were significantly lower than (10.40±0.96) and (9.40±0.70)mmol/L of the control group at 5th and 7th day after treatment，and the differences were statistically significant(P<0.01).The nerve function scores of the observation group were higher than those of the control group at 4th，12th and 24th week after treatment，the differences were statistically significant(P<0.01).Conclusion：The patients with large area cerebral infarction treated by standard large bone flap decompression combined with mild hypothermia have a significant effect，which could optimize S-100B and blood glucose level，and improve the neurological function of patients.The clinical effect is significant and has certain clinical application and research value.
【Key words】 Cerebral infarction； Large area； Mild hypothermia； Standard large bone flap decompression； Neurological function, 百拇医药(朱泳鹏 杨太生 张良 陈大洋 何志深 陈明攀 洪荣庆)